Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk. Single nucleotide pol...

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Veröffentlicht in:	PLoS medicine 2021-07, Vol.18 (7), p.e1003706
Hauptverfasser:	Vithayathil, Mathew, Carter, Paul, Kar, Siddhartha, Mason, Amy M, Burgess, Stephen, Larsson, Susanna C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biobanks Biology and Life Sciences Body composition Body fat Body mass index Body size Breast cancer Cancer Confidence intervals Consortia Digestive system Disease Epidemiology Esophageal cancer Esophagus Estrogens Fat-free body mass Genetic aspects Genetic diversity Genetic variance Health aspects Hodgkin's disease Liver Liver cancer Lung cancer Medicin och hälsovetenskap Medicine and Health Sciences Melanoma Non-Hodgkin's lymphoma Obesity Ovarian cancer Ovaries Pancreas Pancreatic cancer Physiological aspects Prostate cancer Risk factors Single-nucleotide polymorphism Uterine cancer
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