IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes

Extracellular vesicles secreted from IFNγ-stimulated rat dendritic cells (referred to here as IFNγ-DC-EVs) contain miRNAs which promote myelination (including but not limited to miR-219), and preferentially enter oligodendrocytes in brain slice cultures. IFNγ-DC-EVs also increase myelination when na...

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Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0255778-e0255778
Hauptverfasser:	Pusic, Kae M., Kraig, Richard P., Pusic, Aya D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Biology and Life Sciences Bone marrow Brain Brain slice preparation Brain stem Dendritic cells Extracellular vesicles Funding Intranasal administration Intravenous administration Laboratory animals Medicine and Health Sciences Microglia MicroRNAs mRNA Myelination Neuroimaging Neurology Oligodendrocytes Oxidative stress Proteins Research and Analysis Methods Respiration Spinal cord Vesicles γ-Interferon
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