Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding
Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmi...
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| Veröffentlicht in: | PloS one 2021-08, Vol.16 (8), p.e0256043-e0256043 |
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| creator | Alisjahbana, Bachti Koesoemadinata, Raspati Cundarani Hadisoemarto, Panji Fortuna Lestari, Bony Wiem Hartati, Sri Chaidir, Lidya Huang, Chuan-Chin Murray, Megan Hill, Philip Campbell McAllister, Susan Margaret |
| description | Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.
Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB. |
| doi_str_mv | 10.1371/journal.pone.0256043 |
| format | Article |
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Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0256043</identifier><identifier>PMID: 34388190</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Computer and Information Sciences ; Consent ; Contact Tracing - methods ; Cough ; Cough - diagnosis ; Cough - microbiology ; Diagnosis ; Disease prevention ; Disease transmission ; Disease Transmission, Infectious - prevention & control ; Epidemiologic Research Design ; Epidemiology ; Evaluation ; Feasibility studies ; Gene sequencing ; Health risks ; Health sciences ; Hospitals ; Households ; Humans ; Indonesia - epidemiology ; Infectious diseases ; Internal medicine ; Intervention ; Medical diagnosis ; Medical schools ; Medicine ; Medicine and Health Sciences ; Microbiological analysis ; Mycobacterium tuberculosis - isolation & purification ; Mycobacterium tuberculosis - pathogenicity ; Neighborhoods ; Network analysis ; People and Places ; Population ; Prevalence ; Prevalence studies (Epidemiology) ; Public health ; Radiography - methods ; Risk Factors ; Signs and symptoms ; Social networks ; Social organization ; Social Sciences ; Sociodemographics ; Sputum ; Study Protocol ; Supervision ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis - transmission ; Urban areas ; Urban environments ; Whole genome sequencing ; Whole Genome Sequencing - methods</subject><ispartof>PloS one, 2021-08, Vol.16 (8), p.e0256043-e0256043</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Alisjahbana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. 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A protocol for tuberculosis active case finding</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-08-13</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>e0256043</spage><epage>e0256043</epage><pages>e0256043-e0256043</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.
Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34388190</pmid><doi>10.1371/journal.pone.0256043</doi><tpages>e0256043</tpages><orcidid>https://orcid.org/0000-0002-6476-2034</orcidid><orcidid>https://orcid.org/0000-0002-3817-4589</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2561074637 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biology and Life Sciences Computer and Information Sciences Consent Contact Tracing - methods Cough Cough - diagnosis Cough - microbiology Diagnosis Disease prevention Disease transmission Disease Transmission, Infectious - prevention & control Epidemiologic Research Design Epidemiology Evaluation Feasibility studies Gene sequencing Health risks Health sciences Hospitals Households Humans Indonesia - epidemiology Infectious diseases Internal medicine Intervention Medical diagnosis Medical schools Medicine Medicine and Health Sciences Microbiological analysis Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - pathogenicity Neighborhoods Network analysis People and Places Population Prevalence Prevalence studies (Epidemiology) Public health Radiography - methods Risk Factors Signs and symptoms Social networks Social organization Social Sciences Sociodemographics Sputum Study Protocol Supervision Tuberculosis Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - transmission Urban areas Urban environments Whole genome sequencing Whole Genome Sequencing - methods |
| title | Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T12%3A59%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Are%20neighbourhoods%20of%20tuberculosis%20cases%20a%20high-risk%20population%20for%20active%20intervention?%20A%20protocol%20for%20tuberculosis%20active%20case%20finding&rft.jtitle=PloS%20one&rft.au=Alisjahbana,%20Bachti&rft.date=2021-08-13&rft.volume=16&rft.issue=8&rft.spage=e0256043&rft.epage=e0256043&rft.pages=e0256043-e0256043&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0256043&rft_dat=%3Cgale_plos_%3EA671964998%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2561074637&rft_id=info:pmid/34388190&rft_galeid=A671964998&rft_doaj_id=oai_doaj_org_article_1978afa851124e59a665aee89890887a&rfr_iscdi=true |