Outcomes in 1096 patients with severe thrombotic thrombocytopenic purpura before the Caplacizumab era

Thrombotic thrombocytopenic purpura (TTP) is a diagnostic and therapeutic emergency. Therapeutic plasma exchange (TPE) combined with immunosuppression has been the cornerstone of the initial management. To produce optimal benefits, emerging treatments must be used against a background of best standa...

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Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0256024-e0256024
Hauptverfasser:	Van de Louw, Andry, Mariotte, Eric, Darmon, Michael, Cohrs, Austin, Leslie, Douglas, Azoulay, Elie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents, Immunological - therapeutic use Biology and Life Sciences Care and treatment Codes Confidence intervals Female Follow-Up Studies Health sciences Hershey, Milton Snavely Hospitals Humans Immunosuppression Intensive care Male Mechanical ventilation Medicine Medicine and Health Sciences Middle Aged Monoclonal antibodies Mortality Patient outcomes Patients Physical Sciences Plasma Plasma exchange (Therapeutics) Prognosis Public health Purpura Purpura, Thrombotic Thrombocytopenic - drug therapy Purpura, Thrombotic Thrombocytopenic - mortality Purpura, Thrombotic Thrombocytopenic - pathology Retrospective Studies Rituximab Rituximab - therapeutic use Sepsis Single-Domain Antibodies - therapeutic use Software Statistical analysis Survival analysis Survival Rate Thrombocytopenic purpura Thrombotic thrombocytopenic purpura Variables Ventilation
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