Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties

Induced endothelial cells (iECs) generated from neonatal fibroblasts via transdifferentiation have been shown to have pro-angiogenic properties and are a potential therapy for peripheral arterial disease (PAD). It is unknown if iECs can be generated from fibroblasts collected from PAD patients and w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0255075-e0255075
Hauptverfasser:	Hywood, Jack D, Sadeghipour, Sara, Clayton, Zoe E, Yuan, Jun, Stubbs, Colleen, Wong, Jack W T, Cooke, John P, Patel, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Analysis Angiogenesis Animal models Animals Biopsy Capillaries - drug effects Cell Line Cell Movement - drug effects Cell Transdifferentiation - drug effects Collagen - pharmacology Culture Media, Conditioned - pharmacology Cytokines Cytokines - metabolism Diagnosis Drug Combinations Endothelial cells Endothelial Cells - drug effects Endothelial Cells - pathology Endothelial Cells - transplantation Endothelium Fibroblasts Fibroblasts - drug effects Fibroblasts - pathology Health aspects Heart Hindlimb - blood supply Hindlimb - pathology Humans In vivo methods and tests Infant, Newborn Infants (Newborn) Intercellular Signaling Peptides and Proteins - pharmacology Ischemia Ischemia - pathology Ischemia - therapy Laminin - pharmacology Lipoproteins, LDL - metabolism Male Mice Mice, Inbred NOD Mice, SCID mRNA Neonates Neovascularization, Physiologic - drug effects Newborn babies Patients Perfusion Peripheral Arterial Disease - pathology Peripheral vascular diseases Phenotypes Plant Lectins - metabolism Protein Binding - drug effects Proteoglycans - pharmacology Recovery Vascular endothelial growth factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!