Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-07, Vol.16 (7), p.e0254570-e0254570 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0254570 |
|---|---|
| container_issue | 7 |
| container_start_page | e0254570 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo |
| description | Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory. |
| doi_str_mv | 10.1371/journal.pone.0254570 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2556834784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A670178675</galeid><doaj_id>oai_doaj_org_article_ca744df6e34544c38e2c4e925ab190cf</doaj_id><sourcerecordid>A670178675</sourcerecordid><originalsourceid>FETCH-LOGICAL-c735t-d6c894eddeb1b9ebab8dbf96d36cadc81fe1cf858a5029c516aa3e0ba68128963</originalsourceid><addsrcrecordid>eNqNk9-L1DAQx4so3nn6HwgWBNGHrs3Ppj4Ix3HqwsKBv17DNJ30srTNmnQPz7_edrfKVe5B8pAw-cx3MjOZJHlO8hVhBXm79fvQQ7va-R5XORVcFPmD5JSUjGaS5uzhnfNJ8iTGbZ4LpqR8nJwwzmjJGD1NdhvfN9mAoUshRm8cDO4G0w47H25T16cBhvguvbQWzRBTb1MLnWsdBPdrRH2f7jA4X0-or7YjlO1aMJgZ3w_4c0gDGt_07oAOGIenySMLbcRn836WfPtw-fXiU7a5-ri-ON9kpmBiyGppVMmxrrEiVYkVVKqubClrJg3URhGLxFglFIiclkYQCcAwr0AqQlUp2Vny4qi7a33Uc7GipkJIxXih-Eisj0TtYat3wXUQbrUHpw8GHxoNYXCmRW2g4Ly2EhkXnBumkBqOJRVQkTI3dtR6P0fbVx3WBvshQLsQXd707lo3_kYrRlkpxCjwehYI_sd-rJPuXDTYttCj3x_eXVDKOCcj-vIf9P7sZqqBMQHXWz_GNZOoPpdFTgoliyns6h5qXDV2bmwhWjfaFw5vFg5zmxvYx6jXXz7_P3v1fcm-usNeI7TDdfTtfvo3cQnyI2iCjzGg_VtkkutpMP5UQ0-DoefBYL8BcA0BZw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2556834784</pqid></control><display><type>article</type><title>Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>PMC (PubMed Central)</source><source>Full-Text Journals in Chemistry (Open access)</source><source>DOAJ Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Shimoda, Shota ; Ozawa, Takaaki ; Ichitani, Yukio ; Yamada, Kazuo</creator><contributor>Sutherland, Robert</contributor><creatorcontrib>Shimoda, Shota ; Ozawa, Takaaki ; Ichitani, Yukio ; Yamada, Kazuo ; Sutherland, Robert</creatorcontrib><description>Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0254570</identifier><identifier>PMID: 34329332</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Analysis ; Animals ; Associative memory ; Biology and Life Sciences ; Context ; Experiments ; Memory ; Neurosciences ; Object recognition ; Pattern recognition ; Physical Sciences ; Recognition (Psychology) ; Research and Analysis Methods ; Retention ; Rodents ; Social Sciences</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0254570-e0254570</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Shimoda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Shimoda et al 2021 Shimoda et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-d6c894eddeb1b9ebab8dbf96d36cadc81fe1cf858a5029c516aa3e0ba68128963</citedby><cites>FETCH-LOGICAL-c735t-d6c894eddeb1b9ebab8dbf96d36cadc81fe1cf858a5029c516aa3e0ba68128963</cites><orcidid>0000-0003-2249-2037 ; 0000-0003-3633-7062</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79472,79473</link.rule.ids></links><search><contributor>Sutherland, Robert</contributor><creatorcontrib>Shimoda, Shota</creatorcontrib><creatorcontrib>Ozawa, Takaaki</creatorcontrib><creatorcontrib>Ichitani, Yukio</creatorcontrib><creatorcontrib>Yamada, Kazuo</creatorcontrib><title>Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test</title><title>PloS one</title><description>Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.</description><subject>Analysis</subject><subject>Animals</subject><subject>Associative memory</subject><subject>Biology and Life Sciences</subject><subject>Context</subject><subject>Experiments</subject><subject>Memory</subject><subject>Neurosciences</subject><subject>Object recognition</subject><subject>Pattern recognition</subject><subject>Physical Sciences</subject><subject>Recognition (Psychology)</subject><subject>Research and Analysis Methods</subject><subject>Retention</subject><subject>Rodents</subject><subject>Social Sciences</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-L1DAQx4so3nn6HwgWBNGHrs3Ppj4Ix3HqwsKBv17DNJ30srTNmnQPz7_edrfKVe5B8pAw-cx3MjOZJHlO8hVhBXm79fvQQ7va-R5XORVcFPmD5JSUjGaS5uzhnfNJ8iTGbZ4LpqR8nJwwzmjJGD1NdhvfN9mAoUshRm8cDO4G0w47H25T16cBhvguvbQWzRBTb1MLnWsdBPdrRH2f7jA4X0-or7YjlO1aMJgZ3w_4c0gDGt_07oAOGIenySMLbcRn836WfPtw-fXiU7a5-ri-ON9kpmBiyGppVMmxrrEiVYkVVKqubClrJg3URhGLxFglFIiclkYQCcAwr0AqQlUp2Vny4qi7a33Uc7GipkJIxXih-Eisj0TtYat3wXUQbrUHpw8GHxoNYXCmRW2g4Ly2EhkXnBumkBqOJRVQkTI3dtR6P0fbVx3WBvshQLsQXd707lo3_kYrRlkpxCjwehYI_sd-rJPuXDTYttCj3x_eXVDKOCcj-vIf9P7sZqqBMQHXWz_GNZOoPpdFTgoliyns6h5qXDV2bmwhWjfaFw5vFg5zmxvYx6jXXz7_P3v1fcm-usNeI7TDdfTtfvo3cQnyI2iCjzGg_VtkkutpMP5UQ0-DoefBYL8BcA0BZw</recordid><startdate>20210730</startdate><enddate>20210730</enddate><creator>Shimoda, Shota</creator><creator>Ozawa, Takaaki</creator><creator>Ichitani, Yukio</creator><creator>Yamada, Kazuo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2249-2037</orcidid><orcidid>https://orcid.org/0000-0003-3633-7062</orcidid></search><sort><creationdate>20210730</creationdate><title>Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test</title><author>Shimoda, Shota ; Ozawa, Takaaki ; Ichitani, Yukio ; Yamada, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-d6c894eddeb1b9ebab8dbf96d36cadc81fe1cf858a5029c516aa3e0ba68128963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Associative memory</topic><topic>Biology and Life Sciences</topic><topic>Context</topic><topic>Experiments</topic><topic>Memory</topic><topic>Neurosciences</topic><topic>Object recognition</topic><topic>Pattern recognition</topic><topic>Physical Sciences</topic><topic>Recognition (Psychology)</topic><topic>Research and Analysis Methods</topic><topic>Retention</topic><topic>Rodents</topic><topic>Social Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimoda, Shota</creatorcontrib><creatorcontrib>Ozawa, Takaaki</creatorcontrib><creatorcontrib>Ichitani, Yukio</creatorcontrib><creatorcontrib>Yamada, Kazuo</creatorcontrib><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimoda, Shota</au><au>Ozawa, Takaaki</au><au>Ichitani, Yukio</au><au>Yamada, Kazuo</au><au>Sutherland, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test</atitle><jtitle>PloS one</jtitle><date>2021-07-30</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0254570</spage><epage>e0254570</epage><pages>e0254570-e0254570</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34329332</pmid><doi>10.1371/journal.pone.0254570</doi><tpages>e0254570</tpages><orcidid>https://orcid.org/0000-0003-2249-2037</orcidid><orcidid>https://orcid.org/0000-0003-3633-7062</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-07, Vol.16 (7), p.e0254570-e0254570 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2556834784 |
| source | Public Library of Science (PLoS) Journals Open Access; PMC (PubMed Central); Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Analysis Animals Associative memory Biology and Life Sciences Context Experiments Memory Neurosciences Object recognition Pattern recognition Physical Sciences Recognition (Psychology) Research and Analysis Methods Retention Rodents Social Sciences |
| title | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A03%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20associative%20memory%20in%20rats:%20Effects%20of%20familiarization%20period%20in%20object-place-context%20recognition%20test&rft.jtitle=PloS%20one&rft.au=Shimoda,%20Shota&rft.date=2021-07-30&rft.volume=16&rft.issue=7&rft.spage=e0254570&rft.epage=e0254570&rft.pages=e0254570-e0254570&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0254570&rft_dat=%3Cgale_plos_%3EA670178675%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2556834784&rft_id=info:pmid/34329332&rft_galeid=A670178675&rft_doaj_id=oai_doaj_org_article_ca744df6e34544c38e2c4e925ab190cf&rfr_iscdi=true |