Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system
Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-07, Vol.16 (7), p.e0255380 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | e0255380 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Shalaginova, I G Tuchina, O P Sidorova, M V Levina, A S Khlebaeva, D A-A Vaido, A I Dyuzhikova, N A |
| description | Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies. |
| doi_str_mv | 10.1371/journal.pone.0255380 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2556368407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A670025418</galeid><doaj_id>oai_doaj_org_article_a8aff5edd9624b71a8751a7e2e7a03b2</doaj_id><sourcerecordid>A670025418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-2233517f97baf22f8bd70bd51b6fb3312ced9dede38257436d4e371d3940f45f3</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWxc7xBqqoCK1WqxOnWcuzxxosTB9u7dN-Ex8Vh02qDeoFyEXvyzT-Z354keZ7iZUrL9N3Gbl3PzXKwPSwxyXNa4QfJaVpTsigIpg-P1ifJE-83GEemKB4nJzSjJMvr4jT5fakUiOCRVWjwe9HaNfRaIB8c-BjtkbcdoAGcHlpw3CDeSySgD-Na98rwruPBuj3quPsBzscgcjwq_tKhRaEFJHWs4WIKMrADM5aCG6EDb7TRYT_uR6wHt7Nbj_zeB-ieJo8UNx6eTe-z5NuHy68XnxZX1x9XF-dXC1HUJCwIoTRPS1WXDVeEqKqRJW5knjaFaihNiQBZS5BAK5KXGS1kBtE9SesMqyxX9Cx5edAdjPVsMtWz6GdBiyrDZSRWB0JavmGD07HRPbNcs78B69aMu6CFAcYrrlQOUtYFyZoy5VWZp7wEAiXHtCFR6_1Ubdt0ICcfZ6LzL71u2druWEVJSkgdBd5MAs7-3IIPrNNegDG8h2je-N8lIXmdj7Ve_YPe391ErXlsIB6ojXXFKMrOixLHi5WlVaSW91DxkdBpEW-g0jE-S3g7S4hMgJuw5lvv2erL5_9nr7_P2ddHbAvchNZbsw3a9n4OZgdQOOu9A3VncorZOEC3brBxgNg0QDHtxfEB3SXdTgz9A2YWGRE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2556368407</pqid></control><display><type>article</type><title>Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Shalaginova, I G ; Tuchina, O P ; Sidorova, M V ; Levina, A S ; Khlebaeva, D A-A ; Vaido, A I ; Dyuzhikova, N A</creator><contributor>Kavushansky, Alexandra</contributor><creatorcontrib>Shalaginova, I G ; Tuchina, O P ; Sidorova, M V ; Levina, A S ; Khlebaeva, D A-A ; Vaido, A I ; Dyuzhikova, N A ; Kavushansky, Alexandra</creatorcontrib><description>Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0255380</identifier><identifier>PMID: 34324596</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal models in research ; Animals ; Anxiety ; Behavior ; Biology and Life Sciences ; Biomarkers - metabolism ; Blood ; Cytokines ; Epigenetics ; Excitability ; Experiments ; Hippocampus ; Hippocampus - metabolism ; Hypotheses ; Inflammation ; Inflammation - pathology ; Kant, Immanuel (1724-1804) ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes - metabolism ; Male ; Medicine and Health Sciences ; Mental disorders ; Mental illness ; Nervous system ; Neutrophils - metabolism ; Pathogenesis ; Peripheral blood ; Physiology ; Post traumatic stress disorder ; Prenatal development ; Psychological aspects ; Rats ; Rats, Wistar ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Social Sciences ; Stress, Psychological - immunology ; Stress, Psychological - physiopathology</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0255380</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Shalaginova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Shalaginova et al 2021 Shalaginova et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2233517f97baf22f8bd70bd51b6fb3312ced9dede38257436d4e371d3940f45f3</citedby><cites>FETCH-LOGICAL-c692t-2233517f97baf22f8bd70bd51b6fb3312ced9dede38257436d4e371d3940f45f3</cites><orcidid>0000-0002-0140-3077 ; 0000-0002-1082-1801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321229/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321229/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34324596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kavushansky, Alexandra</contributor><creatorcontrib>Shalaginova, I G</creatorcontrib><creatorcontrib>Tuchina, O P</creatorcontrib><creatorcontrib>Sidorova, M V</creatorcontrib><creatorcontrib>Levina, A S</creatorcontrib><creatorcontrib>Khlebaeva, D A-A</creatorcontrib><creatorcontrib>Vaido, A I</creatorcontrib><creatorcontrib>Dyuzhikova, N A</creatorcontrib><title>Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.</description><subject>Analysis</subject><subject>Animal models in research</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - metabolism</subject><subject>Blood</subject><subject>Cytokines</subject><subject>Epigenetics</subject><subject>Excitability</subject><subject>Experiments</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Kant, Immanuel (1724-1804)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Mental illness</subject><subject>Nervous system</subject><subject>Neutrophils - metabolism</subject><subject>Pathogenesis</subject><subject>Peripheral blood</subject><subject>Physiology</subject><subject>Post traumatic stress disorder</subject><subject>Prenatal development</subject><subject>Psychological aspects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Social Sciences</subject><subject>Stress, Psychological - immunology</subject><subject>Stress, Psychological - physiopathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWxc7xBqqoCK1WqxOnWcuzxxosTB9u7dN-Ex8Vh02qDeoFyEXvyzT-Z354keZ7iZUrL9N3Gbl3PzXKwPSwxyXNa4QfJaVpTsigIpg-P1ifJE-83GEemKB4nJzSjJMvr4jT5fakUiOCRVWjwe9HaNfRaIB8c-BjtkbcdoAGcHlpw3CDeSySgD-Na98rwruPBuj3quPsBzscgcjwq_tKhRaEFJHWs4WIKMrADM5aCG6EDb7TRYT_uR6wHt7Nbj_zeB-ieJo8UNx6eTe-z5NuHy68XnxZX1x9XF-dXC1HUJCwIoTRPS1WXDVeEqKqRJW5knjaFaihNiQBZS5BAK5KXGS1kBtE9SesMqyxX9Cx5edAdjPVsMtWz6GdBiyrDZSRWB0JavmGD07HRPbNcs78B69aMu6CFAcYrrlQOUtYFyZoy5VWZp7wEAiXHtCFR6_1Ubdt0ICcfZ6LzL71u2druWEVJSkgdBd5MAs7-3IIPrNNegDG8h2je-N8lIXmdj7Ve_YPe391ErXlsIB6ojXXFKMrOixLHi5WlVaSW91DxkdBpEW-g0jE-S3g7S4hMgJuw5lvv2erL5_9nr7_P2ddHbAvchNZbsw3a9n4OZgdQOOu9A3VncorZOEC3brBxgNg0QDHtxfEB3SXdTgz9A2YWGRE</recordid><startdate>20210729</startdate><enddate>20210729</enddate><creator>Shalaginova, I G</creator><creator>Tuchina, O P</creator><creator>Sidorova, M V</creator><creator>Levina, A S</creator><creator>Khlebaeva, D A-A</creator><creator>Vaido, A I</creator><creator>Dyuzhikova, N A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0140-3077</orcidid><orcidid>https://orcid.org/0000-0002-1082-1801</orcidid></search><sort><creationdate>20210729</creationdate><title>Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system</title><author>Shalaginova, I G ; Tuchina, O P ; Sidorova, M V ; Levina, A S ; Khlebaeva, D A-A ; Vaido, A I ; Dyuzhikova, N A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2233517f97baf22f8bd70bd51b6fb3312ced9dede38257436d4e371d3940f45f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Animal models in research</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Behavior</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - metabolism</topic><topic>Blood</topic><topic>Cytokines</topic><topic>Epigenetics</topic><topic>Excitability</topic><topic>Experiments</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Hypotheses</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Kant, Immanuel (1724-1804)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mental disorders</topic><topic>Mental illness</topic><topic>Nervous system</topic><topic>Neutrophils - metabolism</topic><topic>Pathogenesis</topic><topic>Peripheral blood</topic><topic>Physiology</topic><topic>Post traumatic stress disorder</topic><topic>Prenatal development</topic><topic>Psychological aspects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Research and Analysis Methods</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Social Sciences</topic><topic>Stress, Psychological - immunology</topic><topic>Stress, Psychological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shalaginova, I G</creatorcontrib><creatorcontrib>Tuchina, O P</creatorcontrib><creatorcontrib>Sidorova, M V</creatorcontrib><creatorcontrib>Levina, A S</creatorcontrib><creatorcontrib>Khlebaeva, D A-A</creatorcontrib><creatorcontrib>Vaido, A I</creatorcontrib><creatorcontrib>Dyuzhikova, N A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shalaginova, I G</au><au>Tuchina, O P</au><au>Sidorova, M V</au><au>Levina, A S</au><au>Khlebaeva, D A-A</au><au>Vaido, A I</au><au>Dyuzhikova, N A</au><au>Kavushansky, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-07-29</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0255380</spage><pages>e0255380-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34324596</pmid><doi>10.1371/journal.pone.0255380</doi><tpages>e0255380</tpages><orcidid>https://orcid.org/0000-0002-0140-3077</orcidid><orcidid>https://orcid.org/0000-0002-1082-1801</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-07, Vol.16 (7), p.e0255380 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2556368407 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animal models in research Animals Anxiety Behavior Biology and Life Sciences Biomarkers - metabolism Blood Cytokines Epigenetics Excitability Experiments Hippocampus Hippocampus - metabolism Hypotheses Inflammation Inflammation - pathology Kant, Immanuel (1724-1804) Leukocytes (neutrophilic) Lymphocytes Lymphocytes - metabolism Male Medicine and Health Sciences Mental disorders Mental illness Nervous system Neutrophils - metabolism Pathogenesis Peripheral blood Physiology Post traumatic stress disorder Prenatal development Psychological aspects Rats Rats, Wistar Research and Analysis Methods Risk analysis Risk factors Social Sciences Stress, Psychological - immunology Stress, Psychological - physiopathology |
| title | Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T10%3A25%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20psychogenic%20stress%20on%20some%20peripheral%20and%20central%20inflammatory%20markers%20in%20rats%20with%20the%20different%20level%20of%20excitability%20of%20the%20nervous%20system&rft.jtitle=PloS%20one&rft.au=Shalaginova,%20I%20G&rft.date=2021-07-29&rft.volume=16&rft.issue=7&rft.spage=e0255380&rft.pages=e0255380-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0255380&rft_dat=%3Cgale_plos_%3EA670025418%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2556368407&rft_id=info:pmid/34324596&rft_galeid=A670025418&rft_doaj_id=oai_doaj_org_article_a8aff5edd9624b71a8751a7e2e7a03b2&rfr_iscdi=true |