A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1

The acoustic startle response is an evolutionarily conserved avoidance behavior. Disruptions in startle behavior, particularly startle magnitude, are a hallmark of several human neurological disorders. While the neural circuitry underlying startle behavior has been studied extensively, the repertoir...

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Veröffentlicht in:	PLoS genetics 2021-06, Vol.17 (6), p.e1008943-e1008943
Hauptverfasser:	Meserve, Joy H, Nelson, Jessica C, Marsden, Kurt C, Hsu, Jerry, Echeverry, Fabio A, Jain, Roshan A, Wolman, Marc A, Pereda, Alberto E, Granato, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic startle response Analysis Animal behavior Animals Avoidance behavior Biology and Life Sciences Danio rerio Dolichol Dolichol kinase Genetic analysis Genetic aspects Genetic screening Genetic Testing - methods Genomes Genomics Humans Identification and classification Kinases Kv1.1 Potassium Channel - genetics Medicine and Health Sciences Mutation Neural networks Neurological diseases Phosphotransferases Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - physiology Physical Sciences Physiological aspects Potassium channels Potassium channels (voltage-gated) Reflex, Startle - genetics Research and Analysis Methods Siblings Spinal cord Startle reaction Startle response Stereotyped behavior Zebrafish Zebrafish Proteins - genetics
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