Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial

The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin clearance is postulated to improve protamine dosing precision and coagulation. We hypothesised...

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Veröffentlicht in:	PLoS medicine 2021-06, Vol.18 (6), p.e1003658
Hauptverfasser:	Miles, Lachlan F, Burt, Christiana, Arrowsmith, Joseph, McKie, Mikel A, Villar, Sofia S, Govender, Pooveshnie, Shaylor, Ruth, Tan, Zihui, De Silva, Ravi, Falter, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Biology and Life Sciences Blood Blood Coagulation - drug effects Blood transfusion Body weight Cardiac Surgical Procedures - adverse effects Cardiopulmonary Bypass - adverse effects Catheters Complications and side effects Coronary artery bypass Dosage Dosage and administration Drug Dosage Calculations Drug Monitoring England Erythrocytes Female Health aspects Heart surgery Heparin Heparin - administration & dosage Heparin - adverse effects Heparin Antagonists - administration & dosage Heparin Antagonists - adverse effects Humans Hypothermia Kaolin Male Mathematical models Medicine and Health Sciences Methods Middle Aged Models, Biological Patients Pharmacokinetics Postoperative care Prevention Protamine sulfate Protamines - administration & dosage Protamines - adverse effects Research and Analysis Methods Risk factors Risk groups Surgical drains Thrombelastography Thromboembolism Time Factors Treatment Outcome Victoria Wound drainage
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