Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015
Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and...
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| creator | Choi, Wonsuk Park, Ji Yong Hong, A Ram Yoon, Jee Hee Kim, Hee Kyung Kang, Ho-Cheol |
| description | Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults.
This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.
After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).
This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function. |
| doi_str_mv | 10.1371/journal.pone.0254630 |
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This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.
After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).
This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0254630</identifier><identifier>PMID: 34264998</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Age ; Alcohol ; Alcohol use ; Biology and Life Sciences ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Body mass index ; Cholesterol ; Cross-Sectional Studies ; Dextrose ; Diabetes ; Diabetes mellitus ; Disease control ; Disease prevention ; Exercise ; Female ; Gender differences ; Glucose ; Health aspects ; Humans ; Hypothyroidism ; Insulin ; Insulin Resistance ; Internal medicine ; Male ; Markers ; Measurement ; Medical schools ; Medicine ; Medicine and Health Sciences ; Men ; Metabolic syndrome ; Middle Aged ; Nutrition Surveys ; Physical Sciences ; Polls & surveys ; Regression analysis ; Republic of Korea ; Resistance factors ; Risk analysis ; Risk factors ; Smoking ; Thyroid ; Thyroid Function Tests ; Thyroid gland ; Thyroid Gland - metabolism ; Thyroid-stimulating hormone ; Thyrotropin - blood ; Thyroxine ; Thyroxine - blood ; Triglycerides ; Triglycerides - blood ; Variance analysis ; Women ; Womens health</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0254630</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Choi et al 2021 Choi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-59dc5313a5d76f96aa47476af98df63b7e029d584dc0cd79ff9d51c626f7a0d73</citedby><cites>FETCH-LOGICAL-c692t-59dc5313a5d76f96aa47476af98df63b7e029d584dc0cd79ff9d51c626f7a0d73</cites><orcidid>0000-0002-2494-9902</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281995/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281995/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34264998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lee, Sun Young</contributor><creatorcontrib>Choi, Wonsuk</creatorcontrib><creatorcontrib>Park, Ji Yong</creatorcontrib><creatorcontrib>Hong, A Ram</creatorcontrib><creatorcontrib>Yoon, Jee Hee</creatorcontrib><creatorcontrib>Kim, Hee Kyung</creatorcontrib><creatorcontrib>Kang, Ho-Cheol</creatorcontrib><title>Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults.
This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.
After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).
This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Biology and Life Sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Body mass index</subject><subject>Cholesterol</subject><subject>Cross-Sectional Studies</subject><subject>Dextrose</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Exercise</subject><subject>Female</subject><subject>Gender differences</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Markers</subject><subject>Measurement</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Physical Sciences</subject><subject>Polls & surveys</subject><subject>Regression analysis</subject><subject>Republic of Korea</subject><subject>Resistance factors</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Thyroid</subject><subject>Thyroid Function Tests</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Variance analysis</subject><subject>Women</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk81u1DAQxyMEoqXwBggiISE47OLYiRNzQKqqQiuqVqKFqzVrj3ddee3WTkr3VXhakt206qIeUA5Jxr_5z4dnsux1QaYFq4tPl6GLHtz0KnicElqVnJEn2W4hGJ1wStjTB9872YuULgmpWMP582yHlZSXQjS72Z_9lIKy0Nrg8xm2vxF93kY7dyuF0WqczF2nQsLceo23OXidt4tVDFbnpvNq7Wd9jt2dFXTn2vQ5v1hg_j1EhPx0rQ4uP0Jw7WKtcdr1QUbz4S0srd-kcN7FG1zllBTVy-yZAZfw1fjey35-Pbw4OJqcnH07Ptg_mSguaDuphFYVKxhUuuZGcICyLmsORjTacDarkVChq6bUiihdC2P6v0Jxyk0NRNdsL3u70b1yIcmxrUnSqqKkrAUZiOMNoQNcyqtolxBXMoCVa0OIcwmxtcqhFDUvmGI1V7QuKWqYGQozavqCNFBd9lpfxmjdbIlaoW8juC3R7RNvF3IebmRDm0KIqhf4MArEcN1hauXSJoXOgcfQbfIWghXNkPe7f9DHqxupOfQFWG9CH1cNonKf84aTsqBD3tNHqP7RuLSqn0Fje_uWw8cth55p8badQ5eSPD7_8f_s2a9t9v0DdrEeqRRcN4xP2gbLDahiSCmiuW9yQeSwQnfdkMMKyXGFerc3Dy_o3uluZ9hf1mcZDA</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Choi, Wonsuk</creator><creator>Park, Ji Yong</creator><creator>Hong, A Ram</creator><creator>Yoon, Jee Hee</creator><creator>Kim, Hee Kyung</creator><creator>Kang, Ho-Cheol</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2494-9902</orcidid></search><sort><creationdate>20210715</creationdate><title>Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015</title><author>Choi, Wonsuk ; Park, Ji Yong ; Hong, A Ram ; Yoon, Jee Hee ; Kim, Hee Kyung ; Kang, Ho-Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-59dc5313a5d76f96aa47476af98df63b7e029d584dc0cd79ff9d51c626f7a0d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Biology and Life Sciences</topic><topic>Blood Glucose - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Wonsuk</au><au>Park, Ji Yong</au><au>Hong, A Ram</au><au>Yoon, Jee Hee</au><au>Kim, Hee Kyung</au><au>Kang, Ho-Cheol</au><au>Lee, Sun Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-07-15</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0254630</spage><pages>e0254630-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults.
This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.
After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).
This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34264998</pmid><doi>10.1371/journal.pone.0254630</doi><tpages>e0254630</tpages><orcidid>https://orcid.org/0000-0002-2494-9902</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2552047907 |
| source | MEDLINE; Public Library of Science; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Adults Age Alcohol Alcohol use Biology and Life Sciences Blood Glucose - analysis Blood Glucose - metabolism Body mass index Cholesterol Cross-Sectional Studies Dextrose Diabetes Diabetes mellitus Disease control Disease prevention Exercise Female Gender differences Glucose Health aspects Humans Hypothyroidism Insulin Insulin Resistance Internal medicine Male Markers Measurement Medical schools Medicine Medicine and Health Sciences Men Metabolic syndrome Middle Aged Nutrition Surveys Physical Sciences Polls & surveys Regression analysis Republic of Korea Resistance factors Risk analysis Risk factors Smoking Thyroid Thyroid Function Tests Thyroid gland Thyroid Gland - metabolism Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - blood Triglycerides Triglycerides - blood Variance analysis Women Womens health |
| title | Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T18%3A51%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20triglyceride-glucose%20index%20and%20thyroid%20function%20in%20euthyroid%20adults:%20The%20Korea%20National%20Health%20and%20Nutritional%20Examination%20Survey%202015&rft.jtitle=PloS%20one&rft.au=Choi,%20Wonsuk&rft.date=2021-07-15&rft.volume=16&rft.issue=7&rft.spage=e0254630&rft.pages=e0254630-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0254630&rft_dat=%3Cgale_plos_%3EA668604124%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2552047907&rft_id=info:pmid/34264998&rft_galeid=A668604124&rft_doaj_id=oai_doaj_org_article_97613c376c2742edabf2ab2f201da2d4&rfr_iscdi=true |