Ultrasound-assisted preparation of calcium malate and its absorption
In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-li...
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| Veröffentlicht in: | PloS one 2021-07, Vol.16 (7), p.e0254583 |
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| creator | Ma, Wuren Lv, Yizhou Cao, Xuan Wang, Mengzhi Fan, Yunpeng Shan, Yuanyuan |
| description | In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material. |
| doi_str_mv | 10.1371/journal.pone.0254583 |
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The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0254583</identifier><identifier>PMID: 34265023</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acid phosphatase ; Acid phosphatase (tartrate-resistant) ; Acid resistance ; Alkaline phosphatase ; Alkaline Phosphatase - metabolism ; Analysis ; Animal experimentation ; Animal research ; Animals ; Biology and Life Sciences ; Bone and Bones - metabolism ; Bones ; Calcium ; Calcium (blood) ; Calcium - metabolism ; Calcium absorption ; Calcium compounds ; Calcium content ; Calcium maleate ; Cattle ; Efficiency ; Electric fields ; Engineering ; Evaluation ; Experiments ; Feeds ; Food science ; Hydroxyapatite ; Industrial production ; Laboratory animals ; Malate ; Malates - chemistry ; Malic acid ; Medical research ; Medicine and Health Sciences ; Neutralization (Chemistry) ; Phosphatase ; Phosphorus ; Physical Sciences ; Properties ; Research and Analysis Methods ; Response surface methodology ; Tartrate-Resistant Acid Phosphatase - metabolism ; Ultrasonic imaging ; Ultrasonic methods ; Ultrasonic Waves ; Ultrasound ; Veterinary colleges ; Veterinary medicine</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0254583</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Ma et al 2021 Ma et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-9abc5e2c565f054ea49f475669fc2a5f7a7e40759eb8986a8ff84898d3ef28463</cites><orcidid>0000-0002-6899-4203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282047/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282047/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34265023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Avino, Pasquale</contributor><creatorcontrib>Ma, Wuren</creatorcontrib><creatorcontrib>Lv, Yizhou</creatorcontrib><creatorcontrib>Cao, Xuan</creatorcontrib><creatorcontrib>Wang, Mengzhi</creatorcontrib><creatorcontrib>Fan, Yunpeng</creatorcontrib><creatorcontrib>Shan, Yuanyuan</creatorcontrib><title>Ultrasound-assisted preparation of calcium malate and its absorption</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material.</description><subject>Acid phosphatase</subject><subject>Acid phosphatase (tartrate-resistant)</subject><subject>Acid resistance</subject><subject>Alkaline phosphatase</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Analysis</subject><subject>Animal experimentation</subject><subject>Animal research</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Calcium - metabolism</subject><subject>Calcium absorption</subject><subject>Calcium compounds</subject><subject>Calcium content</subject><subject>Calcium maleate</subject><subject>Cattle</subject><subject>Efficiency</subject><subject>Electric fields</subject><subject>Engineering</subject><subject>Evaluation</subject><subject>Experiments</subject><subject>Feeds</subject><subject>Food science</subject><subject>Hydroxyapatite</subject><subject>Industrial production</subject><subject>Laboratory animals</subject><subject>Malate</subject><subject>Malates - chemistry</subject><subject>Malic acid</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Neutralization (Chemistry)</subject><subject>Phosphatase</subject><subject>Phosphorus</subject><subject>Physical Sciences</subject><subject>Properties</subject><subject>Research and Analysis Methods</subject><subject>Response surface methodology</subject><subject>Tartrate-Resistant Acid Phosphatase - metabolism</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic methods</subject><subject>Ultrasonic Waves</subject><subject>Ultrasound</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLgujFjGmapMmNsKxfAwsL6nobTtNkJkPadJNW9N-bOt1lKnshucghec57ck7eLHteoHVRVsW7vR9DB27d-06vEaaE8vJBdlqIEq8YRuXDo_gkexLjHiFacsYeZyclwYwiXJ5mH67dECD6sWtWEKONg27yPugeAgzWd7k3uQKn7NjmLTgYdA5dk9sh5lBHH_oJepo9MuCifjbvZ9n1p4_fL76sLq8-by7OL1eKkWJYCagV1VhRRg2iRAMRhlSUMWEUBmoqqDRBFRW65oIz4MZwkqKm1AZzwsqz7OVBt3c-ynkAUWJKMZqEaCI2B6LxsJd9sC2E39KDlX8PfNhKCINVTsu6YqgSwhSIcaJQDbpEnKKKEUAG4ana-7naWLe6UbpLk3IL0eVNZ3dy639Kjvn0niTwZhYI_mbUcZCtjUo7B5324-HdQmDGeUJf_YPe391MbSE1YDvjU101icpzxjhDBDGRqPU9VFqNbq1KbjE2nS8S3i4SEjPoX8MWxhjl5tvX_2evfizZ10fsToMbdtG7cbJMXILkAKrgYwza3A25QHIy--005GR2OZs9pb04_qC7pFt3l38AM9b4cw</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Ma, Wuren</creator><creator>Lv, Yizhou</creator><creator>Cao, Xuan</creator><creator>Wang, Mengzhi</creator><creator>Fan, Yunpeng</creator><creator>Shan, Yuanyuan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6899-4203</orcidid></search><sort><creationdate>20210715</creationdate><title>Ultrasound-assisted preparation of calcium malate and its absorption</title><author>Ma, Wuren ; Lv, Yizhou ; Cao, Xuan ; Wang, Mengzhi ; Fan, Yunpeng ; Shan, Yuanyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-9abc5e2c565f054ea49f475669fc2a5f7a7e40759eb8986a8ff84898d3ef28463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acid phosphatase</topic><topic>Acid phosphatase (tartrate-resistant)</topic><topic>Acid resistance</topic><topic>Alkaline phosphatase</topic><topic>Alkaline Phosphatase - 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The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34265023</pmid><doi>10.1371/journal.pone.0254583</doi><tpages>e0254583</tpages><orcidid>https://orcid.org/0000-0002-6899-4203</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Alkaline phosphatase Alkaline Phosphatase - metabolism Analysis Animal experimentation Animal research Animals Biology and Life Sciences Bone and Bones - metabolism Bones Calcium Calcium (blood) Calcium - metabolism Calcium absorption Calcium compounds Calcium content Calcium maleate Cattle Efficiency Electric fields Engineering Evaluation Experiments Feeds Food science Hydroxyapatite Industrial production Laboratory animals Malate Malates - chemistry Malic acid Medical research Medicine and Health Sciences Neutralization (Chemistry) Phosphatase Phosphorus Physical Sciences Properties Research and Analysis Methods Response surface methodology Tartrate-Resistant Acid Phosphatase - metabolism Ultrasonic imaging Ultrasonic methods Ultrasonic Waves Ultrasound Veterinary colleges Veterinary medicine |
| title | Ultrasound-assisted preparation of calcium malate and its absorption |
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