Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes

Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardi...

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Veröffentlicht in:PloS one 2021-07, Vol.16 (7), p.e0254733
Hauptverfasser: Sugita, Yousuke, Ito, Katsuhiko, Sakurai, Shigeki, Sakai, Satoshi, Kuno, Shinya
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Ito, Katsuhiko
Sakurai, Shigeki
Sakai, Satoshi
Kuno, Shinya
description Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.
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However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugita, Yousuke</au><au>Ito, Katsuhiko</au><au>Sakurai, Shigeki</au><au>Sakai, Satoshi</au><au>Kuno, Shinya</au><au>Giannoni, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-07-14</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0254733</spage><pages>e0254733-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p &lt; 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34260663</pmid><doi>10.1371/journal.pone.0254733</doi><tpages>e0254733</tpages><orcidid>https://orcid.org/0000-0002-8578-112X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adipose tissue
Adipose Tissue - diagnostic imaging
Adipose Tissue - physiology
Adipose tissues
Adult
Age
Aged
Aged, 80 and over
Anaerobic threshold
Antihypertensives
Biology and Life Sciences
Blood pressure
Body fat
Body mass index
Cardiac function
Cardiac output
Cardiorespiratory Fitness
Cardiovascular disease
Cholesterol
Confidence intervals
Correlation
Cross-Sectional Studies
Cytokines
Dependent variables
Ejection fraction
Evaluation
Exercise
Exercise Test
Fasting
Female
Fitness
Health aspects
Health sciences
Heart rate
Hemodynamics
Homeostasis
Humans
Inflammation
Insulin resistance
Japan
Magnetic resonance
Magnetic Resonance Imaging
Male
Medical prognosis
Medicine and Health Sciences
Middle Aged
Morphology
Multiple regression analysis
Overweight
Oxygen
Oxygen Consumption
Oxygen uptake
Pericardium - diagnostic imaging
Pericardium - physiology
Physical fitness
Physical Sciences
Quality of life
Regression analysis
Research and Analysis Methods
Sexes
Statistical analysis
Vasomotor conditioning
Womens health
Young Adult
title Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes
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