Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes
Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardi...
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description | Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness. |
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However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0254733</identifier><identifier>PMID: 34260663</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Adipose Tissue - diagnostic imaging ; Adipose Tissue - physiology ; Adipose tissues ; Adult ; Age ; Aged ; Aged, 80 and over ; Anaerobic threshold ; Antihypertensives ; Biology and Life Sciences ; Blood pressure ; Body fat ; Body mass index ; Cardiac function ; Cardiac output ; Cardiorespiratory Fitness ; Cardiovascular disease ; Cholesterol ; Confidence intervals ; Correlation ; Cross-Sectional Studies ; Cytokines ; Dependent variables ; Ejection fraction ; Evaluation ; Exercise ; Exercise Test ; Fasting ; Female ; Fitness ; Health aspects ; Health sciences ; Heart rate ; Hemodynamics ; Homeostasis ; Humans ; Inflammation ; Insulin resistance ; Japan ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical prognosis ; Medicine and Health Sciences ; Middle Aged ; Morphology ; Multiple regression analysis ; Overweight ; Oxygen ; Oxygen Consumption ; Oxygen uptake ; Pericardium - diagnostic imaging ; Pericardium - physiology ; Physical fitness ; Physical Sciences ; Quality of life ; Regression analysis ; Research and Analysis Methods ; Sexes ; Statistical analysis ; Vasomotor conditioning ; Womens health ; Young Adult</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0254733</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Sugita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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diagnostic imaging</subject><subject>Pericardium - physiology</subject><subject>Physical fitness</subject><subject>Physical Sciences</subject><subject>Quality of life</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Sexes</subject><subject>Statistical analysis</subject><subject>Vasomotor conditioning</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYqPwBggiISG4aHHi2ElukKZpQNGkSfy7tU7tk9RVEme2U9b34IFx12xq0C5QLhId_77v2J9zouhlQhYJzZMPGzPYDppFbzpckJRlOaWPotOkpOmcp4Q-Pvo-iZ45tyGE0YLzp9EJzVJOOKen0Z-LXkuwSkMTg9K9cRh77dyAsXYxOGekBo8q_q39Or4ljUXXawve2F1cad-hC2Sn4jW2Ru06aLUMhdZ0dfwVegjrwaxTeqvVAI2LTRVvwWozBKrGgzbUViZ0cHiD7nn0pAogvhjfs-jnp4sf51_ml1efl-dnl3PJy9TPU-AAKVZAi0TSFWZEcVSKS8koICCpCh5iWUm5yrHIS8kU5gwKWco0U0joLHp98O0b48QYqBMpYwnjtKR7YnkglIGN6K1uwe6EAS1uC8bWAqzXskFRoGLAKqIo8iwvE4CEViqTeQUyhK2C18ex27BqUUnsvIVmYjpd6fRa1GYrijQvadjQLHo3GlhzPaDzotVOYtOEiEOY-32nhJMszQP65h_04dONVA3hALqrTOgr96bijPOCkYzkLFCLB6jwKAw3Hf6-Sof6RPB-IgiMxxtfw-CcWH7_9v_s1a8p-_aIXSM0fu1MM3htOjcFswMorXHOYnUfckLEfnju0hD74RHj8ATZq-MLuhfdTQv9CwWZGZk</recordid><startdate>20210714</startdate><enddate>20210714</enddate><creator>Sugita, Yousuke</creator><creator>Ito, Katsuhiko</creator><creator>Sakurai, Shigeki</creator><creator>Sakai, Satoshi</creator><creator>Kuno, Shinya</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8578-112X</orcidid></search><sort><creationdate>20210714</creationdate><title>Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes</title><author>Sugita, Yousuke ; Ito, Katsuhiko ; Sakurai, Shigeki ; Sakai, Satoshi ; Kuno, Shinya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2a6aa2efa381c3be40d6edd6cc53aeae0f86547bccb7e879c5de75a8c9c24de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugita, Yousuke</au><au>Ito, Katsuhiko</au><au>Sakurai, Shigeki</au><au>Sakai, Satoshi</au><au>Kuno, Shinya</au><au>Giannoni, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-07-14</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0254733</spage><pages>e0254733-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34260663</pmid><doi>10.1371/journal.pone.0254733</doi><tpages>e0254733</tpages><orcidid>https://orcid.org/0000-0002-8578-112X</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Adipose tissue Adipose Tissue - diagnostic imaging Adipose Tissue - physiology Adipose tissues Adult Age Aged Aged, 80 and over Anaerobic threshold Antihypertensives Biology and Life Sciences Blood pressure Body fat Body mass index Cardiac function Cardiac output Cardiorespiratory Fitness Cardiovascular disease Cholesterol Confidence intervals Correlation Cross-Sectional Studies Cytokines Dependent variables Ejection fraction Evaluation Exercise Exercise Test Fasting Female Fitness Health aspects Health sciences Heart rate Hemodynamics Homeostasis Humans Inflammation Insulin resistance Japan Magnetic resonance Magnetic Resonance Imaging Male Medical prognosis Medicine and Health Sciences Middle Aged Morphology Multiple regression analysis Overweight Oxygen Oxygen Consumption Oxygen uptake Pericardium - diagnostic imaging Pericardium - physiology Physical fitness Physical Sciences Quality of life Regression analysis Research and Analysis Methods Sexes Statistical analysis Vasomotor conditioning Womens health Young Adult |
title | Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes |
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