Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth

Aggressiveness of cancers, like prostate cancer, has been found to be associated with elevated expression of the microsomal prostaglandin E synthase-1 (mPGES-1). Here, we investigated whether KH176m (the active metabolite of sonlicromanol), a recently discovered selective mPGES-1 inhibitor, could af...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0254315
Hauptverfasser:	Jiang, Xiaolan, Renkema, Herma, Smeitink, Jan, Beyrath, Julien
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences CD44 antigen Cell culture Cell Line, Tumor Cell Proliferation - drug effects Cell self-renewal Cold Cyclooxygenases Development and progression Dinoprostone - metabolism Drug therapy Enzyme inhibitors Feedback control Flow cytometry Gene Expression Regulation, Neoplastic - drug effects Gene regulation Head & neck cancer Health aspects Humans Male Medicine and Health Sciences Metabolites Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic cancer Physiological aspects Positive feedback Prostaglandin E Prostaglandin E2 Prostaglandin-E synthase Prostaglandin-E Synthases - genetics Prostaglandin-E Synthases - metabolism Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Research and analysis methods Spheroids Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cells Transcription Tumors
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