Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis

The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet. EG impairment can play a role in pathogenesis of vascular disease, and one of its characteris...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0253247-e0253247
Hauptverfasser:	Deyab, Gia, Reine, Trine Marita, Vuong, Tram Thu, Jenssen, Trond, Hjeltnes, Gunnbjørg, Agewall, Stefan, Mikkelsen, Knut, Førre, Øystein, Fagerland, Morten Wang, Kolset, Svein Olav, Hollan, Ivana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antirheumatic agents Arthritis Atherogenesis Atherosclerosis Biology and Life Sciences Cardiovascular diseases Chemokines Chronic illnesses Disease Dosage and administration Drug therapy Endothelial cells Endothelium Gelatinase B Health aspects Health risks Health sciences Hospitals Inflammation Laboratories Matrix metalloproteinase Matrix metalloproteinases Measurement Medicine Medicine and Health Sciences Membrane proteins Metabolism Metalloproteinase Methotrexate Mortality Nephrology Pathogenesis Patients Physical Sciences Physiological aspects R&D Research & development Research and Analysis Methods Rheumatoid arthritis Rheumatology Serum levels Shedding Statistical analysis Syndecan Tissue inhibitor of metalloproteinase 1 TNF inhibitors Tumor necrosis factor-TNF Vascular diseases
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