Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions

Pentameric ligand-gated ion channels (pLGICs) activated by the inhibitory neurotransmitter γ-aminobutyric acid (GABA) are expressed widely in both vertebrate and invertebrate species. One of the best characterised insect GABA-gated chloride channels is RDL, an abbreviation of ‘resistance to dieldrin...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0254251-e0254251
Hauptverfasser:	Smelt, Charles L. C, Sanders, Victoria R, Puinean, Alin M, Lansdell, Stuart J, Goodchild, Jim, Millar, Neil S
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Affinity Agonists Allosteric properties Amino acids Analysis Binding sites Biology and Life Sciences Bumblebees Chloride Chloride channels Chloride ions Chlorides Cloning Dieldrin Fruit flies Functional analysis GABA Gametocytes Genetic aspects Genetic screening Glycine Glycine receptors Insects Invertebrates Ion channels Ion channels (ligand-gated) Mutation Neurotransmitters Oocytes Physical Sciences Plasmids Propofol Proteins Receptors Research and Analysis Methods Vertebrates γ-Aminobutyric acid
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