Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon
Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (
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| Veröffentlicht in: | PloS one 2021-07, Vol.16 (7), p.e0253752 |
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| creator | Gomes, Laura Cordeiro Sanson, Marina Cordeiro Gomes Brainin, Philip de Melo, Maria da Conceição Vieira de Souza, Rodrigo Medeiros Mazaro, Janaína Lima, Karine Oliveira Resende, Júnia Silva Vieira, Isabelle Victória Martins Mesquita, Edinilson da Silva Matos, Luan Oliveira Dutra, Isabelle Caroline Silva Palmisano, Giuseppe Wrenger, Carsten Marinho, Claudio Romero Farias da Silva, Rita do Socorro Uchôa |
| description | Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection ( |
| doi_str_mv | 10.1371/journal.pone.0253752 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2547630843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A667082225</galeid><doaj_id>oai_doaj_org_article_f31bf2c0175c403d8d76a6f0197fb56a</doaj_id><sourcerecordid>A667082225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-a47dabec3f3365481bd8a73291f8bf3ee1f6345dc965d5ca2d011c26c40e283b3</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggsISG42CW2Eye5QVoqDitVqsTp1prY48RVYi92trC8AK-Nt91Wu6gXKBeJJ9_84_ntybKnNJ9TXtE3F34dHAzzlXc4z1nJq5Ldy45pw9lMsJzf3_s-yh7FeJHnJa-FeJgd8YI2VUnFcfbnDC9xiMQb0uMKJjvZSN4RcJNtvd6QFMAQCQQkYAyqCTVpNwS6tHaaaB8xkg5WCRyRWEdUbwcd0BET_EiA9LbrCTqNo1VbGdiWmnokPzEmaUcWI_z27nH2wMAQ8cnufZJ9-_D-6-mn2dn5x-Xp4mymRMOmGRSVhhYVN5yLsqhpq2uoOGuoqVvDEakRvCi1akSpSwVM55QqJlSRI6t5y0-y59e6q8FHufMwSlYWleB5XfBELK8J7eFCroIdIWykByuvAj50EsJk1YDScNoapnJalakA17WuBAiTJ3NNWwpIWm931dbtiFqhmwIMB6KHf5ztZecvZc2KWjR1Eni1Ewj-xzo5JkcbFQ4DOPTrq33XBa2Kqknoi3_Qu7vbUR2kBqwzPtVVW1G5EKLKa8bSVTrJ5ndQ6bk6xnThjE3xg4TXBwmJmfDX1ME6Rrn88vn_2fPvh-zLPbZHGKY--mE9We_iIVhcgyr4GAOaW5NpLrfzcuOG3M6L3M1LSnu2f0C3STcDwv8CSYEQTQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547630843</pqid></control><display><type>article</type><title>Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Gomes, Laura Cordeiro ; Sanson, Marina Cordeiro Gomes ; Brainin, Philip ; de Melo, Maria da Conceição Vieira ; de Souza, Rodrigo Medeiros ; Mazaro, Janaína ; Lima, Karine Oliveira ; Resende, Júnia Silva ; Vieira, Isabelle Victória Martins ; Mesquita, Edinilson da Silva ; Matos, Luan Oliveira ; Dutra, Isabelle Caroline Silva ; Palmisano, Giuseppe ; Wrenger, Carsten ; Marinho, Claudio Romero Farias ; da Silva, Rita do Socorro Uchôa</creator><contributor>Chemin, Isabelle</contributor><creatorcontrib>Gomes, Laura Cordeiro ; Sanson, Marina Cordeiro Gomes ; Brainin, Philip ; de Melo, Maria da Conceição Vieira ; de Souza, Rodrigo Medeiros ; Mazaro, Janaína ; Lima, Karine Oliveira ; Resende, Júnia Silva ; Vieira, Isabelle Victória Martins ; Mesquita, Edinilson da Silva ; Matos, Luan Oliveira ; Dutra, Isabelle Caroline Silva ; Palmisano, Giuseppe ; Wrenger, Carsten ; Marinho, Claudio Romero Farias ; da Silva, Rita do Socorro Uchôa ; Chemin, Isabelle</creatorcontrib><description>Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (<10 IU/L).
Our aim was to investigate if age and gap time between HBV vaccine doses may negatively affect the levels of anti-HBs in children, and if these relationships are modified by sex.
In a high-endemic HBV region of the western Brazilian Amazon we enrolled children who had completed the HBV vaccine schedule. All children underwent analysis of anti-HBs and a clinical examination.
We included 522 children (mean age 4.3 ± 0.8 years; 50% male). Median anti-HBs was 28.4 [interquartile range (IQR) 5.4 to 128.6] IU/L and 32% had anti-HBs <10 IU/L. The median gap time from last to preceding dose was 2.4 [IQR 2.1 to 3.3] months. Levels of anti-HBs decreased with higher age (-42% per year increase [95%CI -56% to -24%], p<0.001), but not with longer gap time (+23% per month increase [95%CI -16% to +62%], p = 0.249). After adjusting for relevant confounders, gap time became significant (p = 0.032) and age remained a significant predictor of anti-HBs (p<0.001).
One third of assessed children displayed anti-HBs <10 IU/L. Levels of anti-HBs decreased with higher age and increased with longer gap time between the last two doses.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0253752</identifier><identifier>PMID: 34197516</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age Factors ; Antibodies ; Antigens ; Architects ; Biology and life sciences ; Brazil ; Child, Preschool ; Children ; Cross-Sectional Studies ; Demographic aspects ; Endemic Diseases - prevention & control ; Evaluation ; Female ; Guardians ; Health aspects ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis B - blood ; Hepatitis B - immunology ; Hepatitis B - prevention & control ; Hepatitis B - virology ; Hepatitis B Antibodies - blood ; Hepatitis B Antibodies - immunology ; Hepatitis B Surface Antigens - immunology ; Hepatitis B Vaccines - administration & dosage ; Hepatitis B Vaccines - immunology ; Hepatitis B virus - immunology ; Humans ; Immunization Schedule ; Laboratories ; Male ; Mass Vaccination ; Medicine and health sciences ; Parasitology ; People and places ; Prevention ; Public health ; Regression analysis ; Rural areas ; Schedules ; Serologic Tests - statistics & numerical data ; Serology ; Sport science ; Time Factors ; Vaccines ; Viral antibodies ; Viruses</subject><ispartof>PloS one, 2021-07, Vol.16 (7), p.e0253752</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Gomes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Gomes et al 2021 Gomes et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a47dabec3f3365481bd8a73291f8bf3ee1f6345dc965d5ca2d011c26c40e283b3</citedby><cites>FETCH-LOGICAL-c692t-a47dabec3f3365481bd8a73291f8bf3ee1f6345dc965d5ca2d011c26c40e283b3</cites><orcidid>0000-0001-5102-2523 ; 0000-0002-7161-0098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248698/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248698/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34197516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chemin, Isabelle</contributor><creatorcontrib>Gomes, Laura Cordeiro</creatorcontrib><creatorcontrib>Sanson, Marina Cordeiro Gomes</creatorcontrib><creatorcontrib>Brainin, Philip</creatorcontrib><creatorcontrib>de Melo, Maria da Conceição Vieira</creatorcontrib><creatorcontrib>de Souza, Rodrigo Medeiros</creatorcontrib><creatorcontrib>Mazaro, Janaína</creatorcontrib><creatorcontrib>Lima, Karine Oliveira</creatorcontrib><creatorcontrib>Resende, Júnia Silva</creatorcontrib><creatorcontrib>Vieira, Isabelle Victória Martins</creatorcontrib><creatorcontrib>Mesquita, Edinilson da Silva</creatorcontrib><creatorcontrib>Matos, Luan Oliveira</creatorcontrib><creatorcontrib>Dutra, Isabelle Caroline Silva</creatorcontrib><creatorcontrib>Palmisano, Giuseppe</creatorcontrib><creatorcontrib>Wrenger, Carsten</creatorcontrib><creatorcontrib>Marinho, Claudio Romero Farias</creatorcontrib><creatorcontrib>da Silva, Rita do Socorro Uchôa</creatorcontrib><title>Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (<10 IU/L).
Our aim was to investigate if age and gap time between HBV vaccine doses may negatively affect the levels of anti-HBs in children, and if these relationships are modified by sex.
In a high-endemic HBV region of the western Brazilian Amazon we enrolled children who had completed the HBV vaccine schedule. All children underwent analysis of anti-HBs and a clinical examination.
We included 522 children (mean age 4.3 ± 0.8 years; 50% male). Median anti-HBs was 28.4 [interquartile range (IQR) 5.4 to 128.6] IU/L and 32% had anti-HBs <10 IU/L. The median gap time from last to preceding dose was 2.4 [IQR 2.1 to 3.3] months. Levels of anti-HBs decreased with higher age (-42% per year increase [95%CI -56% to -24%], p<0.001), but not with longer gap time (+23% per month increase [95%CI -16% to +62%], p = 0.249). After adjusting for relevant confounders, gap time became significant (p = 0.032) and age remained a significant predictor of anti-HBs (p<0.001).
One third of assessed children displayed anti-HBs <10 IU/L. Levels of anti-HBs decreased with higher age and increased with longer gap time between the last two doses.</description><subject>Age</subject><subject>Age Factors</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Architects</subject><subject>Biology and life sciences</subject><subject>Brazil</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Demographic aspects</subject><subject>Endemic Diseases - prevention & control</subject><subject>Evaluation</subject><subject>Female</subject><subject>Guardians</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Antibodies - immunology</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B Vaccines - administration & dosage</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>Hepatitis B virus - immunology</subject><subject>Humans</subject><subject>Immunization Schedule</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mass Vaccination</subject><subject>Medicine and health sciences</subject><subject>Parasitology</subject><subject>People and places</subject><subject>Prevention</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Rural areas</subject><subject>Schedules</subject><subject>Serologic Tests - statistics & numerical data</subject><subject>Serology</subject><subject>Sport science</subject><subject>Time Factors</subject><subject>Vaccines</subject><subject>Viral 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Laura Cordeiro</au><au>Sanson, Marina Cordeiro Gomes</au><au>Brainin, Philip</au><au>de Melo, Maria da Conceição Vieira</au><au>de Souza, Rodrigo Medeiros</au><au>Mazaro, Janaína</au><au>Lima, Karine Oliveira</au><au>Resende, Júnia Silva</au><au>Vieira, Isabelle Victória Martins</au><au>Mesquita, Edinilson da Silva</au><au>Matos, Luan Oliveira</au><au>Dutra, Isabelle Caroline Silva</au><au>Palmisano, Giuseppe</au><au>Wrenger, Carsten</au><au>Marinho, Claudio Romero Farias</au><au>da Silva, Rita do Socorro Uchôa</au><au>Chemin, Isabelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>16</volume><issue>7</issue><spage>e0253752</spage><pages>e0253752-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (<10 IU/L).
Our aim was to investigate if age and gap time between HBV vaccine doses may negatively affect the levels of anti-HBs in children, and if these relationships are modified by sex.
In a high-endemic HBV region of the western Brazilian Amazon we enrolled children who had completed the HBV vaccine schedule. All children underwent analysis of anti-HBs and a clinical examination.
We included 522 children (mean age 4.3 ± 0.8 years; 50% male). Median anti-HBs was 28.4 [interquartile range (IQR) 5.4 to 128.6] IU/L and 32% had anti-HBs <10 IU/L. The median gap time from last to preceding dose was 2.4 [IQR 2.1 to 3.3] months. Levels of anti-HBs decreased with higher age (-42% per year increase [95%CI -56% to -24%], p<0.001), but not with longer gap time (+23% per month increase [95%CI -16% to +62%], p = 0.249). After adjusting for relevant confounders, gap time became significant (p = 0.032) and age remained a significant predictor of anti-HBs (p<0.001).
One third of assessed children displayed anti-HBs <10 IU/L. Levels of anti-HBs decreased with higher age and increased with longer gap time between the last two doses.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34197516</pmid><doi>10.1371/journal.pone.0253752</doi><tpages>e0253752</tpages><orcidid>https://orcid.org/0000-0001-5102-2523</orcidid><orcidid>https://orcid.org/0000-0002-7161-0098</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-07, Vol.16 (7), p.e0253752 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2547630843 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Age Factors Antibodies Antigens Architects Biology and life sciences Brazil Child, Preschool Children Cross-Sectional Studies Demographic aspects Endemic Diseases - prevention & control Evaluation Female Guardians Health aspects Health risks Hepatitis Hepatitis B Hepatitis B - blood Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B - virology Hepatitis B Antibodies - blood Hepatitis B Antibodies - immunology Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - immunology Hepatitis B virus - immunology Humans Immunization Schedule Laboratories Male Mass Vaccination Medicine and health sciences Parasitology People and places Prevention Public health Regression analysis Rural areas Schedules Serologic Tests - statistics & numerical data Serology Sport science Time Factors Vaccines Viral antibodies Viruses |
| title | Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T04%3A55%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Levels%20of%20hepatitis%20B%20antibody%20titers%20are%20affected%20by%20age%20and%20doses%20gap%20time%20in%20children%20from%20a%20high%20endemic%20area%20of%20the%20western%20Amazon&rft.jtitle=PloS%20one&rft.au=Gomes,%20Laura%20Cordeiro&rft.date=2021-07-01&rft.volume=16&rft.issue=7&rft.spage=e0253752&rft.pages=e0253752-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0253752&rft_dat=%3Cgale_plos_%3EA667082225%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2547630843&rft_id=info:pmid/34197516&rft_galeid=A667082225&rft_doaj_id=oai_doaj_org_article_f31bf2c0175c403d8d76a6f0197fb56a&rfr_iscdi=true |