The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection

The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain the subject of much debate, partly due to the considerable variation in patient response to metformin. Identification of poor responders by ge...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0253533-e0253533
Hauptverfasser:	Chen, Changwei, Gallagher, Jennifer R, Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E, Ashford, Michael L J, McCrimmon, Rory J, Pearson, Ewan R, McNeilly, Alison D, Sutherland, Calum
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animal tissues Animals Antidiabetics Ataxia Ataxia Telangiectasia Mutated Proteins - genetics Biology and Life Sciences Blood Glucose - analysis Cell culture Cell cycle Cell Cycle Proteins - genetics Cell Line, Tumor Cell lines Chemical compounds Confocal microscopy Depletion Dextrose Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes therapy DNA damage Genes Genetic aspects Genome-Wide Association Study Genomes Genomics Genotypes Glucose Glucose tolerance Glycemic Index - drug effects Glycemic Index - physiology Health aspects HEK293 Cells Hep G2 Cells Hepatocytes Humans Hypoglycemic Agents - therapeutic use Immunoblotting Immunocytochemistry Insulin Insulin resistance Kinases Loci Medical schools Medicine Metformin Metformin - therapeutic use Mice Mice, Inbred C57BL Mice, Knockout NPAT protein Overexpression Pharmacology Phenotypes Physical Sciences Plasmids Polymorphism, Single Nucleotide - genetics Proteins Research and Analysis Methods Single-nucleotide polymorphism Tissue analysis Type 2 diabetes
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