Profiling DNA break sites and transcriptional changes in response to contextual fear learning

Neuronal activity generates DNA double-strand breaks (DSBs) at specific loci in vitro and this facilitates the rapid transcriptional induction of early response genes (ERGs). Physiological neuronal activity, including exposure of mice to learning behaviors, also cause the formation of DSBs, yet the...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0249691-e0249691
Hauptverfasser:	Stott, Ryan T, Kritsky, Oleg, Tsai, Li-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and Life Sciences Brain Deoxyribonucleic acid DNA DNA damage DNA fingerprinting Fear Fear conditioning Gene expression Genes Genetic aspects Genetic engineering Genetic transcription Genomes Glial cells Glucocorticoids Learning Medicine and Health Sciences Memory Neuronal-glial interactions Neurons Ontology Prefrontal cortex Transcription factors
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