Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis
Saliva contains diverse bacteria shed from various oral sites, including subgingival plaque. It is reasonable to focus on the total occupancy of subgingival plaque-specific bacteria (SUBP bacteria), which live in subgingival environments, in the saliva for detecting periodontitis using salivary test...
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| Veröffentlicht in: | PloS one 2021-06, Vol.16 (6), p.e0253502-e0253502 |
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| creator | Ma, Jiale Kageyama, Shinya Takeshita, Toru Shibata, Yukie Furuta, Michiko Asakawa, Mikari Yamashita, Yoshihisa |
| description | Saliva contains diverse bacteria shed from various oral sites, including subgingival plaque. It is reasonable to focus on the total occupancy of subgingival plaque-specific bacteria (SUBP bacteria), which live in subgingival environments, in the saliva for detecting periodontitis using salivary testing. This study aimed to validate the clinical utility of SUBP bacteria in the salivary microbiota for the detection of periodontitis. We examined stimulated saliva samples collected from 125 subjects who visited three dental clinics. The relative abundances of previously identified 11 SUBP bacteria were determined using 16S ribosomal RNA gene sequencing and a reference-based approach. The prediction performance was evaluated using a receiver operating characteristic (ROC) curve. The SUBP bacteria accounted for 0–15.4% of the salivary microbiota, and the percentage distinguished periodontitis patients with at least 15 sites with probing depth ≥4 mm with a sensitivity of 0.90 (95% confidence interval [CI], 0.81–0.98) and specificity of 0.70 (95% CI, 0.60–0.80) (area under the ROC curve [AUC], 0.87). Among 2,047 combinations of 11 SUBP bacteria, combinations including
Streptococcus constellatus
,
Porphyromonas gingivalis
, and
Fusobacterium nucleatum
subsp.
vincentii
demonstrated significantly higher AUC values in their detection. These results suggest that examining SUBP bacteria in saliva may be useful for detecting periodontitis patients in mass screening. |
| doi_str_mv | 10.1371/journal.pone.0253502 |
| format | Article |
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Streptococcus constellatus
,
Porphyromonas gingivalis
, and
Fusobacterium nucleatum
subsp.
vincentii
demonstrated significantly higher AUC values in their detection. These results suggest that examining SUBP bacteria in saliva may be useful for detecting periodontitis patients in mass screening.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0253502</identifier><identifier>PMID: 34170942</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Bacteria ; Biology and Life Sciences ; Confidence intervals ; Dentistry ; Diagnosis ; Ecology and Environmental Sciences ; Evaluation ; Gene sequencing ; Genetic aspects ; Gingiva ; Gum disease ; Medical tests ; Medicine and Health Sciences ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Occupancy ; Oral hygiene ; Pathogens ; Periodontitis ; Public health ; rRNA 16S ; Saliva ; Sample size ; Taxonomy</subject><ispartof>PloS one, 2021-06, Vol.16 (6), p.e0253502-e0253502</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Ma et al 2021 Ma et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c696t-7df0f04cbc5aee9df52565850aedcd143715f5cd7aa6a50c49fad0f44b4b1673</citedby><cites>FETCH-LOGICAL-c696t-7df0f04cbc5aee9df52565850aedcd143715f5cd7aa6a50c49fad0f44b4b1673</cites><orcidid>0000-0003-4326-7613 ; 0000-0001-9296-9385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232462/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232462/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids></links><search><creatorcontrib>Ma, Jiale</creatorcontrib><creatorcontrib>Kageyama, Shinya</creatorcontrib><creatorcontrib>Takeshita, Toru</creatorcontrib><creatorcontrib>Shibata, Yukie</creatorcontrib><creatorcontrib>Furuta, Michiko</creatorcontrib><creatorcontrib>Asakawa, Mikari</creatorcontrib><creatorcontrib>Yamashita, Yoshihisa</creatorcontrib><title>Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis</title><title>PloS one</title><description>Saliva contains diverse bacteria shed from various oral sites, including subgingival plaque. It is reasonable to focus on the total occupancy of subgingival plaque-specific bacteria (SUBP bacteria), which live in subgingival environments, in the saliva for detecting periodontitis using salivary testing. This study aimed to validate the clinical utility of SUBP bacteria in the salivary microbiota for the detection of periodontitis. We examined stimulated saliva samples collected from 125 subjects who visited three dental clinics. The relative abundances of previously identified 11 SUBP bacteria were determined using 16S ribosomal RNA gene sequencing and a reference-based approach. The prediction performance was evaluated using a receiver operating characteristic (ROC) curve. The SUBP bacteria accounted for 0–15.4% of the salivary microbiota, and the percentage distinguished periodontitis patients with at least 15 sites with probing depth ≥4 mm with a sensitivity of 0.90 (95% confidence interval [CI], 0.81–0.98) and specificity of 0.70 (95% CI, 0.60–0.80) (area under the ROC curve [AUC], 0.87). Among 2,047 combinations of 11 SUBP bacteria, combinations including
Streptococcus constellatus
,
Porphyromonas gingivalis
, and
Fusobacterium nucleatum
subsp.
vincentii
demonstrated significantly higher AUC values in their detection. These results suggest that examining SUBP bacteria in saliva may be useful for detecting periodontitis patients in mass screening.</description><subject>Bacteria</subject><subject>Biology and Life Sciences</subject><subject>Confidence intervals</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Ecology and Environmental Sciences</subject><subject>Evaluation</subject><subject>Gene sequencing</subject><subject>Genetic aspects</subject><subject>Gingiva</subject><subject>Gum disease</subject><subject>Medical tests</subject><subject>Medicine and Health Sciences</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Occupancy</subject><subject>Oral hygiene</subject><subject>Pathogens</subject><subject>Periodontitis</subject><subject>Public health</subject><subject>rRNA 16S</subject><subject>Saliva</subject><subject>Sample 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utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis</title><author>Ma, Jiale ; Kageyama, Shinya ; Takeshita, Toru ; Shibata, Yukie ; Furuta, Michiko ; Asakawa, Mikari ; Yamashita, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c696t-7df0f04cbc5aee9df52565850aedcd143715f5cd7aa6a50c49fad0f44b4b1673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bacteria</topic><topic>Biology and Life Sciences</topic><topic>Confidence intervals</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Ecology and Environmental Sciences</topic><topic>Evaluation</topic><topic>Gene sequencing</topic><topic>Genetic aspects</topic><topic>Gingiva</topic><topic>Gum disease</topic><topic>Medical tests</topic><topic>Medicine and Health Sciences</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic 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periodontitis</atitle><jtitle>PloS one</jtitle><date>2021-06-25</date><risdate>2021</risdate><volume>16</volume><issue>6</issue><spage>e0253502</spage><epage>e0253502</epage><pages>e0253502-e0253502</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Saliva contains diverse bacteria shed from various oral sites, including subgingival plaque. It is reasonable to focus on the total occupancy of subgingival plaque-specific bacteria (SUBP bacteria), which live in subgingival environments, in the saliva for detecting periodontitis using salivary testing. This study aimed to validate the clinical utility of SUBP bacteria in the salivary microbiota for the detection of periodontitis. We examined stimulated saliva samples collected from 125 subjects who visited three dental clinics. The relative abundances of previously identified 11 SUBP bacteria were determined using 16S ribosomal RNA gene sequencing and a reference-based approach. The prediction performance was evaluated using a receiver operating characteristic (ROC) curve. The SUBP bacteria accounted for 0–15.4% of the salivary microbiota, and the percentage distinguished periodontitis patients with at least 15 sites with probing depth ≥4 mm with a sensitivity of 0.90 (95% confidence interval [CI], 0.81–0.98) and specificity of 0.70 (95% CI, 0.60–0.80) (area under the ROC curve [AUC], 0.87). Among 2,047 combinations of 11 SUBP bacteria, combinations including
Streptococcus constellatus
,
Porphyromonas gingivalis
, and
Fusobacterium nucleatum
subsp.
vincentii
demonstrated significantly higher AUC values in their detection. These results suggest that examining SUBP bacteria in saliva may be useful for detecting periodontitis patients in mass screening.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34170942</pmid><doi>10.1371/journal.pone.0253502</doi><tpages>e0253502</tpages><orcidid>https://orcid.org/0000-0003-4326-7613</orcidid><orcidid>https://orcid.org/0000-0001-9296-9385</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bacteria Biology and Life Sciences Confidence intervals Dentistry Diagnosis Ecology and Environmental Sciences Evaluation Gene sequencing Genetic aspects Gingiva Gum disease Medical tests Medicine and Health Sciences Microbiota Microbiota (Symbiotic organisms) Microorganisms Occupancy Oral hygiene Pathogens Periodontitis Public health rRNA 16S Saliva Sample size Taxonomy |
| title | Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis |
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