Allele and haplotype frequencies of human leukocyte antigen-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 by next generation sequencing-based typing in Koreans in South Korea

Allele frequencies and haplotype frequencies of HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 have been rarely reported in South Koreans using unambiguous, phase-resolved next generation DNA sequencing. In this study, HLA typing of 11 loci in 173 healthy South Koreans were performe...

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Veröffentlicht in:	PloS one 2021-06, Vol.16 (6), p.e0253619-e0253619
Hauptverfasser:	Baek, In-Cheol, Choi, Eun-Jeong, Shin, Dong-Hwan, Kim, Hyoung-Jae, Choi, Haeyoun, Kim, Tai-Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Ambiguity Analysis Antigens Biology and Life Sciences Computer and Information Sciences Deoxyribonucleic acid DNA DNA sequencing DQA1 protein Drafting software Drb1 protein Engineering and Technology Funding Gene amplification Gene frequency Genetic aspects Haplotypes Hematopoietic stem cells Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Homogeneity Leukocytes Medical schools Medicine Medicine and Health Sciences Methodology Methods Microbiology Minority & ethnic groups Morbidity Next-generation sequencing Nucleotide sequencing People and Places Population Population genetics Research and analysis methods Sample preparation Software Stem cell transplantation Stem cells Tissue typing Transplantation Transplants & implants
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