Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes

Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer. Copy number alterations are important drivers...

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Veröffentlicht in:	PLoS genetics 2021-05, Vol.17 (5), p.e1009557
Hauptverfasser:	Wang, Shixiang, Li, Huimin, Song, Minfang, Tao, Ziyu, Wu, Tao, He, Zaoke, Zhao, Xiangyu, Wu, Kai, Liu, Xue-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Biomarkers, Tumor Chromosomes Copy number Copy number variations Datasets Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics DNA damage DNA Mutational Analysis Double-strand break repair Genetic aspects Genome, Human - genetics Genomes Genomic Instability Genomics Health aspects Humans Male Medicine and Health Sciences Metastases Mutagenesis - genetics Mutation Mutation (Biology) Ovarian cancer Patient outcomes Prognosis Proportional Hazards Models Prostate cancer Prostatic Neoplasms - classification Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Quality control Software Survival Analysis Treatment Outcome Tumors
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