Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) and evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, and local and systemic inflammation in...

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Veröffentlicht in:PLoS pathogens 2021-05, Vol.17 (5), p.e1009565
Hauptverfasser: Bochart, Rachele M, Busman-Sahay, Kathleen, Bondoc, Stephen, Morrow, David W, Ortiz, Alexandra M, Fennessey, Christine M, Fischer, Miranda B, Shiel, Oriene, Swanson, Tonya, Shriver-Munsch, Christine M, Crank, Hugh B, Armantrout, Kimberly M, Barber-Axthelm, Aaron M, Langner, Charlotte, Moats, Cassandra R, Labriola, Caralyn S, MacAllister, Rhonda, Axthelm, Michael K, Brenchley, Jason M, Keele, Brandon F, Estes, Jacob D, Hansen, Scott G, Smedley, Jeremy V
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Sprache:eng
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