Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments

It is well documented that influenza A viruses selectively package 8 distinct viral ribonucleoprotein complexes (vRNPs) into each virion; however, the role of host factors in genome assembly is not completely understood. To evaluate the significance of cellular factors in genome assembly, we generat...

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Veröffentlicht in:	PLoS pathogens 2021-05, Vol.17 (5), p.e1009517-e1009517
Hauptverfasser:	Han, Julianna, Ganti, Ketaki, Sali, Veeresh Kumar, Twigg, Carly, Zhang, Yifeng, Manivasagam, Senthamizharasi, Liang, Chieh-Yu, Vogel, Olivia A, Huang, Iris, Emmanuel, Shanan N, Plung, Jesse, Radoshevich, Lillianna, Perez, Jasmine T, Lowen, Anice C, Manicassamy, Balaji
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Actin Antibodies Assembly Biology and life sciences Cytoplasm Egress Exports Fluorescence Fluorescence microscopy Genetic aspects Genome, Viral Genomes Health aspects HEK293 Cells Host-virus relationships Humans Influenza Influenza A Influenza A virus - genetics Influenza A virus - isolation & purification Influenza viruses Influenza, Human - genetics Influenza, Human - virology Medicine and health sciences Microscopy Packaging Proteins rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Reagents Research and Analysis Methods Ribonucleoproteins Ribonucleoproteins - genetics Ribonucleoproteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism Virions Virulence (Microbiology) Virus Assembly Virus Replication Viruses
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