Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan
Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure. We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensit...
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| creator | Hatsusaka, Natsuko Yamamoto, Naoki Miyashita, Hisanori Shibuya, Eri Mita, Norihiro Yamazaki, Mai Shibata, Teppei Ishida, Hidetoshi Ukai, Yuki Kubo, Eri Cheng, Hong-Ming Sasaki, Hiroshi |
| description | Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure. We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. From that study, we identified 1,547 subjects with information on the presence or absence of pterygium. Pterygium severity was graded by corneal progress rate. Cataracts were graded by classification systems as three main types (cortical, nuclear, posterior subcapsular) and three subtypes (retrodots, waterclefts, fiber folds) with high prevalence in middle-aged and elderly people. We calculated the cumulative ocular UV exposure (COUV) based on subject data and National Aeronautics and Space Administration data on UV intensities and used logistic regression to calculate odds ratios for the associations of COUV, cataract, and pterygium. We found an overall pterygium prevalence of 23.3%, with significant variation among the three regions. Four cataract types (cortical, nuclear, posterior subcapsular, and retrodots) were significantly associated with the presence of pterygium. There was a significant association between COUV and pterygium, indicating that COUV is associated with the risk of pterygium development and that pterygium is useful as an index of UV exposure. Furthermore, the type of cataract in eyes with pterygium may indicate the level of UV exposure. |
| doi_str_mv | 10.1371/journal.pone.0253093 |
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This study explored the relationships between six cataract types with pterygium and UV exposure. We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. From that study, we identified 1,547 subjects with information on the presence or absence of pterygium. Pterygium severity was graded by corneal progress rate. Cataracts were graded by classification systems as three main types (cortical, nuclear, posterior subcapsular) and three subtypes (retrodots, waterclefts, fiber folds) with high prevalence in middle-aged and elderly people. We calculated the cumulative ocular UV exposure (COUV) based on subject data and National Aeronautics and Space Administration data on UV intensities and used logistic regression to calculate odds ratios for the associations of COUV, cataract, and pterygium. We found an overall pterygium prevalence of 23.3%, with significant variation among the three regions. Four cataract types (cortical, nuclear, posterior subcapsular, and retrodots) were significantly associated with the presence of pterygium. There was a significant association between COUV and pterygium, indicating that COUV is associated with the risk of pterygium development and that pterygium is useful as an index of UV exposure. Furthermore, the type of cataract in eyes with pterygium may indicate the level of UV exposure.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0253093</identifier><identifier>PMID: 34129614</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Auroral kilometric radiation ; Biology and Life Sciences ; Cataract ; Cataracts ; Confidence intervals ; Cornea ; Cross-sectional studies ; Diabetes ; Diagnosis ; Editing ; Environmental health ; Eye ; Eye (anatomy) ; Eye diseases ; Funding ; Health aspects ; Health risks ; Medical research ; Medicine and Health Sciences ; Methodology ; Ophthalmology ; Optometry ; Physical Sciences ; Radiation ; Regression analysis ; Research and Analysis Methods ; Research facilities ; Reviews ; Risk analysis ; Risk factors ; Statistical analysis ; Ultraviolet radiation ; Vision</subject><ispartof>PloS one, 2021-06, Vol.16 (6), p.e0253093</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Hatsusaka et al. 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Hiroshi</au><au>Hejtmancik, James Fielding</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan</atitle><jtitle>PloS one</jtitle><date>2021-06-15</date><risdate>2021</risdate><volume>16</volume><issue>6</issue><spage>e0253093</spage><pages>e0253093-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure. We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. From that study, we identified 1,547 subjects with information on the presence or absence of pterygium. Pterygium severity was graded by corneal progress rate. Cataracts were graded by classification systems as three main types (cortical, nuclear, posterior subcapsular) and three subtypes (retrodots, waterclefts, fiber folds) with high prevalence in middle-aged and elderly people. We calculated the cumulative ocular UV exposure (COUV) based on subject data and National Aeronautics and Space Administration data on UV intensities and used logistic regression to calculate odds ratios for the associations of COUV, cataract, and pterygium. We found an overall pterygium prevalence of 23.3%, with significant variation among the three regions. Four cataract types (cortical, nuclear, posterior subcapsular, and retrodots) were significantly associated with the presence of pterygium. There was a significant association between COUV and pterygium, indicating that COUV is associated with the risk of pterygium development and that pterygium is useful as an index of UV exposure. Furthermore, the type of cataract in eyes with pterygium may indicate the level of UV exposure.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34129614</pmid><doi>10.1371/journal.pone.0253093</doi><tpages>e0253093</tpages><orcidid>https://orcid.org/0000-0001-6789-9311</orcidid><orcidid>https://orcid.org/0000-0003-0216-3869</orcidid><orcidid>https://orcid.org/0000-0002-6458-5330</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Auroral kilometric radiation Biology and Life Sciences Cataract Cataracts Confidence intervals Cornea Cross-sectional studies Diabetes Diagnosis Editing Environmental health Eye Eye (anatomy) Eye diseases Funding Health aspects Health risks Medical research Medicine and Health Sciences Methodology Ophthalmology Optometry Physical Sciences Radiation Regression analysis Research and Analysis Methods Research facilities Reviews Risk analysis Risk factors Statistical analysis Ultraviolet radiation Vision |
| title | Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan |
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