Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder
Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women...
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| Veröffentlicht in: | PloS one 2021-06, Vol.16 (6), p.e0248831-e0248831 |
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| creator | Oscar-Berman, Marlene Ruiz, Susan Mosher Marinkovic, Ksenija Valmas, Mary M Harris, Gordon J Sawyer, Kayle S |
| description | Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women [AUDw], 21 men [AUDm]) and demographically similar non-AUD control (NC) participants without AUD (21 women [NCw], 21 men [NCm]) to explore how gender and AUD interact to influence brain responses during emotional processing and memory. Participants completed a delayed match-to-sample emotional face memory fMRI task, and brain activation contrasts between a fixation stimulus and pictures of emotional face elicited a similar overall pattern of activation for all four groups. Significant Group by Gender interactions revealed two activation clusters. A cluster in an anterior portion of the middle and superior temporal gyrus, elicited lower activation to the fixation stimulus than to faces for the AUDw as compared to the NCw; that abnormality was more pronounced than the one observed for men. Another cluster in the medial portion of the superior frontal cortex elicited higher activation to the faces by AUDm than NCm, a difference that was more evident than the one observed for women. Together, these findings have added new evidence of AUD-related gender differences in neural responses to facial expressions of emotion. |
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We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women [AUDw], 21 men [AUDm]) and demographically similar non-AUD control (NC) participants without AUD (21 women [NCw], 21 men [NCm]) to explore how gender and AUD interact to influence brain responses during emotional processing and memory. Participants completed a delayed match-to-sample emotional face memory fMRI task, and brain activation contrasts between a fixation stimulus and pictures of emotional face elicited a similar overall pattern of activation for all four groups. Significant Group by Gender interactions revealed two activation clusters. A cluster in an anterior portion of the middle and superior temporal gyrus, elicited lower activation to the fixation stimulus than to faces for the AUDw as compared to the NCw; that abnormality was more pronounced than the one observed for men. 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Together, these findings have added new evidence of AUD-related gender differences in neural responses to facial expressions of emotion.</description><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcoholism</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Anatomy</subject><subject>Biology and Life Sciences</subject><subject>Brain stimulation</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Computer programs</subject><subject>Data analysis</subject><subject>Dementia disorders</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Drafting software</subject><subject>Drinking behavior</subject><subject>Drinking of alcoholic beverages</subject><subject>Drug abuse</subject><subject>Editing</subject><subject>Emotions</subject><subject>Epilepsy</subject><subject>Ethanol</subject><subject>Facial expression</subject><subject>Funding</subject><subject>Gender 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oscar-Berman, Marlene</au><au>Ruiz, Susan Mosher</au><au>Marinkovic, Ksenija</au><au>Valmas, Mary M</au><au>Harris, Gordon J</au><au>Sawyer, Kayle S</au><au>Jung, Wi Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder</atitle><jtitle>PloS one</jtitle><date>2021-06-09</date><risdate>2021</risdate><volume>16</volume><issue>6</issue><spage>e0248831</spage><epage>e0248831</epage><pages>e0248831-e0248831</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. 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Another cluster in the medial portion of the superior frontal cortex elicited higher activation to the faces by AUDm than NCm, a difference that was more evident than the one observed for women. Together, these findings have added new evidence of AUD-related gender differences in neural responses to facial expressions of emotion.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34106934</pmid><doi>10.1371/journal.pone.0248831</doi><tpages>e0248831</tpages><orcidid>https://orcid.org/0000-0001-7767-5688</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alcohol use Alcoholic beverages Alcoholism Alcohols Analysis Anatomy Biology and Life Sciences Brain stimulation Care and treatment Comparative analysis Computer programs Data analysis Dementia disorders Demographic aspects Diagnosis Drafting software Drinking behavior Drinking of alcoholic beverages Drug abuse Editing Emotions Epilepsy Ethanol Facial expression Funding Gender differences Health aspects Health care HIV Human immunodeficiency virus Liver diseases Magnetic resonance imaging Medicine Medicine and Health Sciences Mental disorders Nervous system Physical Sciences Physiological aspects Psychology Radiology Research and Analysis Methods Reviews Schizophrenia Signs and symptoms Social Sciences Software Trauma Visualization |
| title | Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder |
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