Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis
Adverse drug reactions (ADRs) represent a major cause of iatrogenic morbidity and mortality in patient care. While a substantial body of work has been undertaken to characterise ADRs in the hospital setting, the overall burden of ADRs in the primary care remains unclear. To investigate the prevalenc...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-05, Vol.16 (5), p.e0252161 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e0252161 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Insani, Widya N Whittlesea, Cate Alwafi, Hassan Man, Kenneth K. C Chapman, Sarah Wei, Li |
| description | Adverse drug reactions (ADRs) represent a major cause of iatrogenic morbidity and mortality in patient care. While a substantial body of work has been undertaken to characterise ADRs in the hospital setting, the overall burden of ADRs in the primary care remains unclear. To investigate the prevalence of ADRs in the primary care setting and factors affecting the heterogeneity of the estimates. Studies were identified through searching of Medline, Embase, CINAHL and IPA databases. We included observational studies that reported information on the prevalence of ADRs in patients receiving primary care. Disease and treatment specific studies were excluded. Quality of the included studies were assessed using Smyth ADRs adapted scale. A random-effects model was used to calculate the pooled estimate. Potential source of heterogeneity, including age groups, ADRs definitions, ADRs detection methods, study setting, quality of the studies, and sample size, were investigated using sub-group analysis and meta-regression. Thirty-three studies with a total study population of 1,568,164 individuals were included. The pooled prevalence of ADRs in the primary care setting was 8.32% (95% CI, 7.82, 8.83). The percentage of preventable ADRs ranged from 12.35-37.96%, with the pooled estimate of 22.96% (95% CI, 7.82, 38.09). Cardiovascular system drugs were the most commonly implicated medication class. Methods of ADRs detection, age group, setting, and sample size contributed significantly to the heterogeneity of the estimates. ADRs constitute a significant health problem in the primary care setting. Further research should focus on examining whether ADRs affect subsequent clinical outcomes, particularly in high-risk therapeutic areas. This information may better inform strategies to reduce the burden of ADRs in the primary care setting. |
| doi_str_mv | 10.1371/journal.pone.0252161 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2532531370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A663144640</galeid><doaj_id>oai_doaj_org_article_0e81d2ae7f6d4e4ea9d3eeae3c571b02</doaj_id><sourcerecordid>A663144640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-6c84daded4e8130f392305a8359708a1afcd9d46a0450726f5da71495621f3363</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rr6DwQDguDFjEmTpq0XwrD4MbCw4tdtOJucdjK0zZiko_PvzexU2YKCJJBw8pw3Jydvlj1ldMl4yV5t3egH6JY7N-CS5kXOJLuXnbOa5wuZU37_zv4sexTCltKCV1I-zM64oLwSpTjP2o8e99DhoJG4hoDZow9IjB9b4hF0tG4IxA4kbpDsvO3BH4gGjyRgjHZoX5MVCYcQsYdodcrZW_xBYDCkxwgLSCUegg2PswcNdAGfTOtF9vXd2y-XHxZX1-_Xl6urhZayjgupK2HAoBFYMU4bXuecFlDxoi5pBQwabWojJFBR0DKXTWGgZKIuZM4aziW_yJ6ddHedC2rqUVB5wdNMfaOJWJ8I42CrpicpB1bdBpxvFfj0lA4VTUWYHLBsZCpIINSGIwJyXZTshuZJ681023jTo9E4RA_dTHR-MtiNat1eVazgghdJ4Pkk4N33EUP8R8kT1aafUnZoXBLTvQ1araTkTAgpjtTyL1QaBnurk0sam-KzhJezhMRE_BlbGENQ68-f_p-9_jZnX9xhNwhd3ATXjbdemoPiBGrvQvDY_Okco-po8t_dUEeTq8nk_BcJeO2l</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2532531370</pqid></control><display><type>article</type><title>Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Insani, Widya N ; Whittlesea, Cate ; Alwafi, Hassan ; Man, Kenneth K. C ; Chapman, Sarah ; Wei, Li</creator><contributor>Vaismoradi, Mojtaba</contributor><creatorcontrib>Insani, Widya N ; Whittlesea, Cate ; Alwafi, Hassan ; Man, Kenneth K. C ; Chapman, Sarah ; Wei, Li ; Vaismoradi, Mojtaba</creatorcontrib><description>Adverse drug reactions (ADRs) represent a major cause of iatrogenic morbidity and mortality in patient care. While a substantial body of work has been undertaken to characterise ADRs in the hospital setting, the overall burden of ADRs in the primary care remains unclear. To investigate the prevalence of ADRs in the primary care setting and factors affecting the heterogeneity of the estimates. Studies were identified through searching of Medline, Embase, CINAHL and IPA databases. We included observational studies that reported information on the prevalence of ADRs in patients receiving primary care. Disease and treatment specific studies were excluded. Quality of the included studies were assessed using Smyth ADRs adapted scale. A random-effects model was used to calculate the pooled estimate. Potential source of heterogeneity, including age groups, ADRs definitions, ADRs detection methods, study setting, quality of the studies, and sample size, were investigated using sub-group analysis and meta-regression. Thirty-three studies with a total study population of 1,568,164 individuals were included. The pooled prevalence of ADRs in the primary care setting was 8.32% (95% CI, 7.82, 8.83). The percentage of preventable ADRs ranged from 12.35-37.96%, with the pooled estimate of 22.96% (95% CI, 7.82, 38.09). Cardiovascular system drugs were the most commonly implicated medication class. Methods of ADRs detection, age group, setting, and sample size contributed significantly to the heterogeneity of the estimates. ADRs constitute a significant health problem in the primary care setting. Further research should focus on examining whether ADRs affect subsequent clinical outcomes, particularly in high-risk therapeutic areas. This information may better inform strategies to reduce the burden of ADRs in the primary care setting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0252161</identifier><identifier>PMID: 34038474</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Adverse and side effects ; Allergies ; Analysis ; Angiotensin ; Angiotensin-converting enzyme inhibitors ; Ankle ; Antidotes ; Antifungal agents ; Calcium ; Calcium channel blockers ; Calcium channels ; Community health care ; Cough ; Drug dosages ; Drug therapy ; Drugs ; Edema ; Enzyme inhibitors ; Flucloxacillin ; Fungicides ; Health care ; Health risks ; Heterogeneity ; Hospitals ; Hypersensitivity ; Internal medicine ; Long term health care ; Medical errors ; Medical records ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Muscles ; Myopathy ; Patient admissions ; Penicillin ; People and Places ; Peptidyl-dipeptidase A ; Pharmaceuticals ; Pharmacology ; Pharmacy ; Prevalence studies (Epidemiology) ; Primary care ; Public health ; Side effects ; Systematic review</subject><ispartof>PloS one, 2021-05, Vol.16 (5), p.e0252161</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Insani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Insani et al 2021 Insani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-6c84daded4e8130f392305a8359708a1afcd9d46a0450726f5da71495621f3363</citedby><cites>FETCH-LOGICAL-c669t-6c84daded4e8130f392305a8359708a1afcd9d46a0450726f5da71495621f3363</cites><orcidid>0000-0002-0066-9746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153435/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153435/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Vaismoradi, Mojtaba</contributor><creatorcontrib>Insani, Widya N</creatorcontrib><creatorcontrib>Whittlesea, Cate</creatorcontrib><creatorcontrib>Alwafi, Hassan</creatorcontrib><creatorcontrib>Man, Kenneth K. C</creatorcontrib><creatorcontrib>Chapman, Sarah</creatorcontrib><creatorcontrib>Wei, Li</creatorcontrib><title>Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis</title><title>PloS one</title><description>Adverse drug reactions (ADRs) represent a major cause of iatrogenic morbidity and mortality in patient care. While a substantial body of work has been undertaken to characterise ADRs in the hospital setting, the overall burden of ADRs in the primary care remains unclear. To investigate the prevalence of ADRs in the primary care setting and factors affecting the heterogeneity of the estimates. Studies were identified through searching of Medline, Embase, CINAHL and IPA databases. We included observational studies that reported information on the prevalence of ADRs in patients receiving primary care. Disease and treatment specific studies were excluded. Quality of the included studies were assessed using Smyth ADRs adapted scale. A random-effects model was used to calculate the pooled estimate. Potential source of heterogeneity, including age groups, ADRs definitions, ADRs detection methods, study setting, quality of the studies, and sample size, were investigated using sub-group analysis and meta-regression. Thirty-three studies with a total study population of 1,568,164 individuals were included. The pooled prevalence of ADRs in the primary care setting was 8.32% (95% CI, 7.82, 8.83). The percentage of preventable ADRs ranged from 12.35-37.96%, with the pooled estimate of 22.96% (95% CI, 7.82, 38.09). Cardiovascular system drugs were the most commonly implicated medication class. Methods of ADRs detection, age group, setting, and sample size contributed significantly to the heterogeneity of the estimates. ADRs constitute a significant health problem in the primary care setting. Further research should focus on examining whether ADRs affect subsequent clinical outcomes, particularly in high-risk therapeutic areas. This information may better inform strategies to reduce the burden of ADRs in the primary care setting.</description><subject>Adverse and side effects</subject><subject>Allergies</subject><subject>Analysis</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme inhibitors</subject><subject>Ankle</subject><subject>Antidotes</subject><subject>Antifungal agents</subject><subject>Calcium</subject><subject>Calcium channel blockers</subject><subject>Calcium channels</subject><subject>Community health care</subject><subject>Cough</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Edema</subject><subject>Enzyme inhibitors</subject><subject>Flucloxacillin</subject><subject>Fungicides</subject><subject>Health care</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Hospitals</subject><subject>Hypersensitivity</subject><subject>Internal medicine</subject><subject>Long term health care</subject><subject>Medical errors</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Muscles</subject><subject>Myopathy</subject><subject>Patient admissions</subject><subject>Penicillin</subject><subject>People and Places</subject><subject>Peptidyl-dipeptidase A</subject><subject>Pharmaceuticals</subject><subject>Pharmacology</subject><subject>Pharmacy</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Primary care</subject><subject>Public health</subject><subject>Side effects</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6DwQDguDFjEmTpq0XwrD4MbCw4tdtOJucdjK0zZiko_PvzexU2YKCJJBw8pw3Jydvlj1ldMl4yV5t3egH6JY7N-CS5kXOJLuXnbOa5wuZU37_zv4sexTCltKCV1I-zM64oLwSpTjP2o8e99DhoJG4hoDZow9IjB9b4hF0tG4IxA4kbpDsvO3BH4gGjyRgjHZoX5MVCYcQsYdodcrZW_xBYDCkxwgLSCUegg2PswcNdAGfTOtF9vXd2y-XHxZX1-_Xl6urhZayjgupK2HAoBFYMU4bXuecFlDxoi5pBQwabWojJFBR0DKXTWGgZKIuZM4aziW_yJ6ddHedC2rqUVB5wdNMfaOJWJ8I42CrpicpB1bdBpxvFfj0lA4VTUWYHLBsZCpIINSGIwJyXZTshuZJ681023jTo9E4RA_dTHR-MtiNat1eVazgghdJ4Pkk4N33EUP8R8kT1aafUnZoXBLTvQ1araTkTAgpjtTyL1QaBnurk0sam-KzhJezhMRE_BlbGENQ68-f_p-9_jZnX9xhNwhd3ATXjbdemoPiBGrvQvDY_Okco-po8t_dUEeTq8nk_BcJeO2l</recordid><startdate>20210526</startdate><enddate>20210526</enddate><creator>Insani, Widya N</creator><creator>Whittlesea, Cate</creator><creator>Alwafi, Hassan</creator><creator>Man, Kenneth K. C</creator><creator>Chapman, Sarah</creator><creator>Wei, Li</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0066-9746</orcidid></search><sort><creationdate>20210526</creationdate><title>Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis</title><author>Insani, Widya N ; Whittlesea, Cate ; Alwafi, Hassan ; Man, Kenneth K. C ; Chapman, Sarah ; Wei, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-6c84daded4e8130f392305a8359708a1afcd9d46a0450726f5da71495621f3363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adverse and side effects</topic><topic>Allergies</topic><topic>Analysis</topic><topic>Angiotensin</topic><topic>Angiotensin-converting enzyme inhibitors</topic><topic>Ankle</topic><topic>Antidotes</topic><topic>Antifungal agents</topic><topic>Calcium</topic><topic>Calcium channel blockers</topic><topic>Calcium channels</topic><topic>Community health care</topic><topic>Cough</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>Edema</topic><topic>Enzyme inhibitors</topic><topic>Flucloxacillin</topic><topic>Fungicides</topic><topic>Health care</topic><topic>Health risks</topic><topic>Heterogeneity</topic><topic>Hospitals</topic><topic>Hypersensitivity</topic><topic>Internal medicine</topic><topic>Long term health care</topic><topic>Medical errors</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Muscles</topic><topic>Myopathy</topic><topic>Patient admissions</topic><topic>Penicillin</topic><topic>People and Places</topic><topic>Peptidyl-dipeptidase A</topic><topic>Pharmaceuticals</topic><topic>Pharmacology</topic><topic>Pharmacy</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Primary care</topic><topic>Public health</topic><topic>Side effects</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Insani, Widya N</creatorcontrib><creatorcontrib>Whittlesea, Cate</creatorcontrib><creatorcontrib>Alwafi, Hassan</creatorcontrib><creatorcontrib>Man, Kenneth K. C</creatorcontrib><creatorcontrib>Chapman, Sarah</creatorcontrib><creatorcontrib>Wei, Li</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Insani, Widya N</au><au>Whittlesea, Cate</au><au>Alwafi, Hassan</au><au>Man, Kenneth K. C</au><au>Chapman, Sarah</au><au>Wei, Li</au><au>Vaismoradi, Mojtaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><date>2021-05-26</date><risdate>2021</risdate><volume>16</volume><issue>5</issue><spage>e0252161</spage><pages>e0252161-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adverse drug reactions (ADRs) represent a major cause of iatrogenic morbidity and mortality in patient care. While a substantial body of work has been undertaken to characterise ADRs in the hospital setting, the overall burden of ADRs in the primary care remains unclear. To investigate the prevalence of ADRs in the primary care setting and factors affecting the heterogeneity of the estimates. Studies were identified through searching of Medline, Embase, CINAHL and IPA databases. We included observational studies that reported information on the prevalence of ADRs in patients receiving primary care. Disease and treatment specific studies were excluded. Quality of the included studies were assessed using Smyth ADRs adapted scale. A random-effects model was used to calculate the pooled estimate. Potential source of heterogeneity, including age groups, ADRs definitions, ADRs detection methods, study setting, quality of the studies, and sample size, were investigated using sub-group analysis and meta-regression. Thirty-three studies with a total study population of 1,568,164 individuals were included. The pooled prevalence of ADRs in the primary care setting was 8.32% (95% CI, 7.82, 8.83). The percentage of preventable ADRs ranged from 12.35-37.96%, with the pooled estimate of 22.96% (95% CI, 7.82, 38.09). Cardiovascular system drugs were the most commonly implicated medication class. Methods of ADRs detection, age group, setting, and sample size contributed significantly to the heterogeneity of the estimates. ADRs constitute a significant health problem in the primary care setting. Further research should focus on examining whether ADRs affect subsequent clinical outcomes, particularly in high-risk therapeutic areas. This information may better inform strategies to reduce the burden of ADRs in the primary care setting.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34038474</pmid><doi>10.1371/journal.pone.0252161</doi><tpages>e0252161</tpages><orcidid>https://orcid.org/0000-0002-0066-9746</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-05, Vol.16 (5), p.e0252161 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2532531370 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adverse and side effects Allergies Analysis Angiotensin Angiotensin-converting enzyme inhibitors Ankle Antidotes Antifungal agents Calcium Calcium channel blockers Calcium channels Community health care Cough Drug dosages Drug therapy Drugs Edema Enzyme inhibitors Flucloxacillin Fungicides Health care Health risks Heterogeneity Hospitals Hypersensitivity Internal medicine Long term health care Medical errors Medical records Medicine Medicine and Health Sciences Meta-analysis Muscles Myopathy Patient admissions Penicillin People and Places Peptidyl-dipeptidase A Pharmaceuticals Pharmacology Pharmacy Prevalence studies (Epidemiology) Primary care Public health Side effects Systematic review |
| title | Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T13%3A30%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20adverse%20drug%20reactions%20in%20the%20primary%20care%20setting:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Insani,%20Widya%20N&rft.date=2021-05-26&rft.volume=16&rft.issue=5&rft.spage=e0252161&rft.pages=e0252161-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0252161&rft_dat=%3Cgale_plos_%3EA663144640%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2532531370&rft_id=info:pmid/34038474&rft_galeid=A663144640&rft_doaj_id=oai_doaj_org_article_0e81d2ae7f6d4e4ea9d3eeae3c571b02&rfr_iscdi=true |