Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients
COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and biochemical variables associated with AKI progression in patients with severe COVID-19 remain unclear. We performed a retrospective study on 278 hospitalized patients who were adm...
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| creator | de Almeida, Danilo Candido Franco, Maria do Carmo Pinho dos Santos, Davi Rettori Pardo Santos, Marina Colella Maltoni, Isabela Soucin Mascotte, Felipe de Souza, Alexandra Aparecida Pietrobom, Paula Massaroni Medeiros, Eduardo Alexandrino Ferreira, Paulo Roberto Abrão Machado, Flavia Ribeiro Goes, Miguel Angelo |
| description | COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and biochemical variables associated with AKI progression in patients with severe COVID-19 remain unclear. We performed a retrospective study on 278 hospitalized patients who were admitted to the ward and intensive care unit (ICU) with COVID-19 between March 2020 and June 2020, at the University Hospital, São Paulo, Brazil. Patients aged [greater than or equal to] 18 years with COVID-19 confirmed on RT-PCR were included. AKI was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We evaluated the incidence of AKI, several clinical variables, medicines used, and outcomes in two sub-groups: COVID-19 patients with AKI (Cov-AKI), and COVID-19 patients without AKI (non-AKI). Univariate and multivariate analyses were performed. First, an elevated incidence of AKI (71.2%) was identified, distributed across different stages of the KDIGO criteria. We further observed higher levels of creatinine, C-reactive protein (CRP), leukocytes, neutrophils, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in the Cov-AKI group than in the non-AKI group, at hospital admission. On univariate analysis, Cov-AKI was associated with older age (>62 years), hypertension, CRP, MCV, leucocytes, neutrophils, NLR, combined hydroxychloroquine and azithromycin treatment, use of mechanical ventilation, and vasoactive drugs. Multivariate analysis showed that hypertension and the use of vasoactive drugs were independently associated with a risk of higher AKI in COVID-19 patients. Finally, we preferentially found an altered erythrocyte and leukocyte cellular profile in the Cov-AKI group compared to the non-AKI group, at hospital discharge. In our study, the development of AKI in patients with severe COVID-19 was related to inflammatory blood markers and therapy with hydroxychloroquine/azithromycin, with vasopressor requirement and hypertension considered potential risk factors. Thus, attention to the protocol, hypertension, and some blood markers may help assist doctors with decision-making for the management of COVID-19 patients with AKI. |
| doi_str_mv | 10.1371/journal.pone.0251048 |
| format | Article |
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However, the precise clinical and biochemical variables associated with AKI progression in patients with severe COVID-19 remain unclear. We performed a retrospective study on 278 hospitalized patients who were admitted to the ward and intensive care unit (ICU) with COVID-19 between March 2020 and June 2020, at the University Hospital, São Paulo, Brazil. Patients aged [greater than or equal to] 18 years with COVID-19 confirmed on RT-PCR were included. AKI was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We evaluated the incidence of AKI, several clinical variables, medicines used, and outcomes in two sub-groups: COVID-19 patients with AKI (Cov-AKI), and COVID-19 patients without AKI (non-AKI). Univariate and multivariate analyses were performed. First, an elevated incidence of AKI (71.2%) was identified, distributed across different stages of the KDIGO criteria. We further observed higher levels of creatinine, C-reactive protein (CRP), leukocytes, neutrophils, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in the Cov-AKI group than in the non-AKI group, at hospital admission. On univariate analysis, Cov-AKI was associated with older age (>62 years), hypertension, CRP, MCV, leucocytes, neutrophils, NLR, combined hydroxychloroquine and azithromycin treatment, use of mechanical ventilation, and vasoactive drugs. Multivariate analysis showed that hypertension and the use of vasoactive drugs were independently associated with a risk of higher AKI in COVID-19 patients. Finally, we preferentially found an altered erythrocyte and leukocyte cellular profile in the Cov-AKI group compared to the non-AKI group, at hospital discharge. In our study, the development of AKI in patients with severe COVID-19 was related to inflammatory blood markers and therapy with hydroxychloroquine/azithromycin, with vasopressor requirement and hypertension considered potential risk factors. Thus, attention to the protocol, hypertension, and some blood markers may help assist doctors with decision-making for the management of COVID-19 patients with AKI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0251048</identifier><identifier>PMID: 34033655</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Almeida, Maria ; Biology and Life Sciences ; Blood ; Blood cells ; Cardiovascular diseases ; Chronic kidney failure ; Complications ; Coronary artery disease ; Coronaviruses ; COVID-19 ; Creatinine ; Diabetes ; Diabetes mellitus ; Electronic health records ; Electronic medical records ; Epithelium ; Funding ; Gas analysis ; Health risks ; Heart diseases ; Hospitalization ; Hospitals ; Hypertension ; Infections ; Infectious diseases ; Intensive care ; Kidney diseases ; Kidneys ; Liver diseases ; Mechanical ventilation ; Medicine and Health Sciences ; Mesangial cells ; Mortality ; Nephrology ; Patient outcomes ; Patients ; Risk analysis ; Risk factors ; Severe acute respiratory syndrome coronavirus 2 ; Software ; Ventilation ; Ventilators ; Viral infections</subject><ispartof>PloS one, 2021-05, Vol.16 (5), p.e0251048-e0251048</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 de Almeida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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However, the precise clinical and biochemical variables associated with AKI progression in patients with severe COVID-19 remain unclear. We performed a retrospective study on 278 hospitalized patients who were admitted to the ward and intensive care unit (ICU) with COVID-19 between March 2020 and June 2020, at the University Hospital, São Paulo, Brazil. Patients aged [greater than or equal to] 18 years with COVID-19 confirmed on RT-PCR were included. AKI was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We evaluated the incidence of AKI, several clinical variables, medicines used, and outcomes in two sub-groups: COVID-19 patients with AKI (Cov-AKI), and COVID-19 patients without AKI (non-AKI). Univariate and multivariate analyses were performed. First, an elevated incidence of AKI (71.2%) was identified, distributed across different stages of the KDIGO criteria. We further observed higher levels of creatinine, C-reactive protein (CRP), leukocytes, neutrophils, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in the Cov-AKI group than in the non-AKI group, at hospital admission. On univariate analysis, Cov-AKI was associated with older age (>62 years), hypertension, CRP, MCV, leucocytes, neutrophils, NLR, combined hydroxychloroquine and azithromycin treatment, use of mechanical ventilation, and vasoactive drugs. Multivariate analysis showed that hypertension and the use of vasoactive drugs were independently associated with a risk of higher AKI in COVID-19 patients. Finally, we preferentially found an altered erythrocyte and leukocyte cellular profile in the Cov-AKI group compared to the non-AKI group, at hospital discharge. 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Thus, attention to the protocol, hypertension, and some blood markers may help assist doctors with decision-making for the management of COVID-19 patients with AKI.</description><subject>Almeida, Maria</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Cardiovascular diseases</subject><subject>Chronic kidney failure</subject><subject>Complications</subject><subject>Coronary artery disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Epithelium</subject><subject>Funding</subject><subject>Gas analysis</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Infectious 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disease</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Epithelium</topic><topic>Funding</topic><topic>Gas analysis</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive care</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Liver diseases</topic><topic>Mechanical ventilation</topic><topic>Medicine and Health Sciences</topic><topic>Mesangial cells</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Severe acute respiratory syndrome coronavirus 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kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients</atitle><jtitle>PloS one</jtitle><date>2021-05-25</date><risdate>2021</risdate><volume>16</volume><issue>5</issue><spage>e0251048</spage><epage>e0251048</epage><pages>e0251048-e0251048</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and biochemical variables associated with AKI progression in patients with severe COVID-19 remain unclear. We performed a retrospective study on 278 hospitalized patients who were admitted to the ward and intensive care unit (ICU) with COVID-19 between March 2020 and June 2020, at the University Hospital, São Paulo, Brazil. Patients aged [greater than or equal to] 18 years with COVID-19 confirmed on RT-PCR were included. AKI was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We evaluated the incidence of AKI, several clinical variables, medicines used, and outcomes in two sub-groups: COVID-19 patients with AKI (Cov-AKI), and COVID-19 patients without AKI (non-AKI). Univariate and multivariate analyses were performed. First, an elevated incidence of AKI (71.2%) was identified, distributed across different stages of the KDIGO criteria. We further observed higher levels of creatinine, C-reactive protein (CRP), leukocytes, neutrophils, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in the Cov-AKI group than in the non-AKI group, at hospital admission. On univariate analysis, Cov-AKI was associated with older age (>62 years), hypertension, CRP, MCV, leucocytes, neutrophils, NLR, combined hydroxychloroquine and azithromycin treatment, use of mechanical ventilation, and vasoactive drugs. Multivariate analysis showed that hypertension and the use of vasoactive drugs were independently associated with a risk of higher AKI in COVID-19 patients. Finally, we preferentially found an altered erythrocyte and leukocyte cellular profile in the Cov-AKI group compared to the non-AKI group, at hospital discharge. In our study, the development of AKI in patients with severe COVID-19 was related to inflammatory blood markers and therapy with hydroxychloroquine/azithromycin, with vasopressor requirement and hypertension considered potential risk factors. Thus, attention to the protocol, hypertension, and some blood markers may help assist doctors with decision-making for the management of COVID-19 patients with AKI.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34033655</pmid><doi>10.1371/journal.pone.0251048</doi><tpages>e0251048</tpages><orcidid>https://orcid.org/0000-0003-3661-2124</orcidid><orcidid>https://orcid.org/0000-0001-7687-3826</orcidid><orcidid>https://orcid.org/0000-0003-0360-9922</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-05, Vol.16 (5), p.e0251048-e0251048 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2532078138 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Almeida, Maria Biology and Life Sciences Blood Blood cells Cardiovascular diseases Chronic kidney failure Complications Coronary artery disease Coronaviruses COVID-19 Creatinine Diabetes Diabetes mellitus Electronic health records Electronic medical records Epithelium Funding Gas analysis Health risks Heart diseases Hospitalization Hospitals Hypertension Infections Infectious diseases Intensive care Kidney diseases Kidneys Liver diseases Mechanical ventilation Medicine and Health Sciences Mesangial cells Mortality Nephrology Patient outcomes Patients Risk analysis Risk factors Severe acute respiratory syndrome coronavirus 2 Software Ventilation Ventilators Viral infections |
| title | Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients |
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