Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we used a transgenic mouse model with 2- to 3-fold inc...

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Veröffentlicht in:	PloS one 2021-05, Vol.16 (5), p.e0252142-e0252142
Hauptverfasser:	Sridharan, Vijayalakshmi, Johnson, Kristin A, Landes, Reid D, Cao, Maohua, Singh, Preeti, Wagoner, Gail, Hayar, Abdallah, Sprick, Emily D, Eveld, Kayla A, Bhattacharyya, Anusha, Krager, Kimberly J, Aykin-Burns, Nukhet, Weiler, Hartmut, Fernández, Jose A, Griffin, John H, Boerma, Marjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated protein C Anesthesia Animals Auroral kilometric radiation Biology and Life Sciences Bone marrow Cesium 137 Cesium isotopes Cesium radioisotopes Data analysis Demographic aspects Dentistry Dosimetry Drug dosages Editing Exposure Female Funding Gamma rays Genetic aspects Genotype Granulocytes Heart - radiation effects Heart Rate - radiation effects Immunoblotting Immunohistochemistry Inflammation Injuries Intestine Intestine, Small - metabolism Intestine, Small - radiation effects Ionizing radiation Irradiation Laboratory animals Male Medicine Medicine and Health Sciences Methodology Mice Mice, Inbred C57BL Military facilities Military personnel Nervous system Neurosciences Nuclear engineering Nuclear facilities Occupational exposure Pharmaceutical sciences Pharmaceuticals Pharmacy Physical Sciences Protein C Protein C - metabolism Proteins Radiation Radiation effects Radiation injuries Research and Analysis Methods Reviews Rocks Skin - metabolism Skin - radiation effects Small intestine Thrombin Visualization
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