Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery
Experimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate. Systemic elevation of syndecan-1 and heparan sulfate is well described in cardiac surgery. Still, the events during immediate reperfusion after...
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| description | Experimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate. Systemic elevation of syndecan-1 and heparan sulfate is well described in cardiac surgery. Still, the events during immediate reperfusion after aortic declamping are unknown both in the systemic and in the coronary circulation.
In thirty patients undergoing aortic valve replacement, arterial concentrations of syndecan-1 and heparan sulfate were measured immediately before and at one, five and ten minutes after aortic declamping (reperfusion). Parallel blood samples were drawn from the coronary sinus to calculate trans-coronary gradients (coronary sinus-artery).
Compared with immediately before aortic declamping, arterial syndecan-1 increased by 18% [253.8 (151.6-372.0) ng/ml vs. 299.1 (172.0-713.7) ng/ml, p < 0.001] but arterial heparan sulfate decreased by 14% [148.1 (135.7-161.7) ng/ml vs. 128.0 (119.0-138.2) ng/ml, p < 0.001] at one minute after aortic declamping. There was no coronary washout of syndecan-1 or heparan sulfate during reperfusion. On the contrary, trans-coronary sequestration of syndecan-1 occurred at five [-12.96 ng/ml (-36.38-5.15), p = 0.007] and at ten minutes [-12.37 ng/ml (-31.80-6.62), p = 0.049] after reperfusion.
Aortic declamping resulted in extracardiac syndecan-1 release and extracardiac heparan sulfate sequestration. Syndecan-1 was sequestered in the coronary circulation during early reperfusion. Glycocalyx has been shown to degrade during cardiac surgery. Besides degradation, glycocalyx has propensity for regeneration. The present results of syndecan-1 and heparan sulfate sequestration may reflect endogenous restoration of the damaged glycocalyx in open heart surgery. |
| doi_str_mv | 10.1371/journal.pone.0251747 |
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In thirty patients undergoing aortic valve replacement, arterial concentrations of syndecan-1 and heparan sulfate were measured immediately before and at one, five and ten minutes after aortic declamping (reperfusion). Parallel blood samples were drawn from the coronary sinus to calculate trans-coronary gradients (coronary sinus-artery).
Compared with immediately before aortic declamping, arterial syndecan-1 increased by 18% [253.8 (151.6-372.0) ng/ml vs. 299.1 (172.0-713.7) ng/ml, p < 0.001] but arterial heparan sulfate decreased by 14% [148.1 (135.7-161.7) ng/ml vs. 128.0 (119.0-138.2) ng/ml, p < 0.001] at one minute after aortic declamping. There was no coronary washout of syndecan-1 or heparan sulfate during reperfusion. On the contrary, trans-coronary sequestration of syndecan-1 occurred at five [-12.96 ng/ml (-36.38-5.15), p = 0.007] and at ten minutes [-12.37 ng/ml (-31.80-6.62), p = 0.049] after reperfusion.
Aortic declamping resulted in extracardiac syndecan-1 release and extracardiac heparan sulfate sequestration. Syndecan-1 was sequestered in the coronary circulation during early reperfusion. Glycocalyx has been shown to degrade during cardiac surgery. Besides degradation, glycocalyx has propensity for regeneration. The present results of syndecan-1 and heparan sulfate sequestration may reflect endogenous restoration of the damaged glycocalyx in open heart surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0251747</identifier><identifier>PMID: 33999952</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Analysis ; Anesthesiology ; Anticoagulants ; Aorta ; Aortic valve ; Aspirin ; Biology and Life Sciences ; Biomarkers ; Blood circulation ; Blood vessels ; Cardiac patients ; Cardiovascular disease ; Care and treatment ; Catheters ; Coronary artery ; Coronary artery disease ; Coronary circulation ; Editing ; Endothelium ; Engineering and Technology ; Fibrillation ; Glucocorticoids ; Glycocalyx ; Glycosaminoglycans ; Heart ; Heart diseases ; Heart surgery ; Heart valves ; Hemoglobin ; Heparan sulfate ; Immunosuppressive agents ; Intensive care ; Ischemia ; Medicine ; Medicine and Health Sciences ; Methodology ; Pain ; Patients ; Physical Sciences ; Plasma ; Proteins ; Proteoglycans ; Pulmonary arteries ; Reperfusion ; Research facilities ; Rheumatic heart disease ; Surgery ; Syndecan ; Ventricle</subject><ispartof>PloS one, 2021-05, Vol.16 (5), p.e0251747-e0251747</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Passov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Passov et al 2021 Passov et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-24226108e8394864179372ecaf702e5d537e1313638bf334a7bebe528b7c55c63</citedby><cites>FETCH-LOGICAL-c692t-24226108e8394864179372ecaf702e5d537e1313638bf334a7bebe528b7c55c63</cites><orcidid>0000-0002-4126-610X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128269/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128269/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33999952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Passov, Arie</creatorcontrib><creatorcontrib>Schramko, Alexey</creatorcontrib><creatorcontrib>Salminen, Ulla-Stina</creatorcontrib><creatorcontrib>Aittomäki, Juha</creatorcontrib><creatorcontrib>Andersson, Sture</creatorcontrib><creatorcontrib>Pesonen, Eero</creatorcontrib><title>Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Experimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate. Systemic elevation of syndecan-1 and heparan sulfate is well described in cardiac surgery. Still, the events during immediate reperfusion after aortic declamping are unknown both in the systemic and in the coronary circulation.
In thirty patients undergoing aortic valve replacement, arterial concentrations of syndecan-1 and heparan sulfate were measured immediately before and at one, five and ten minutes after aortic declamping (reperfusion). Parallel blood samples were drawn from the coronary sinus to calculate trans-coronary gradients (coronary sinus-artery).
Compared with immediately before aortic declamping, arterial syndecan-1 increased by 18% [253.8 (151.6-372.0) ng/ml vs. 299.1 (172.0-713.7) ng/ml, p < 0.001] but arterial heparan sulfate decreased by 14% [148.1 (135.7-161.7) ng/ml vs. 128.0 (119.0-138.2) ng/ml, p < 0.001] at one minute after aortic declamping. There was no coronary washout of syndecan-1 or heparan sulfate during reperfusion. On the contrary, trans-coronary sequestration of syndecan-1 occurred at five [-12.96 ng/ml (-36.38-5.15), p = 0.007] and at ten minutes [-12.37 ng/ml (-31.80-6.62), p = 0.049] after reperfusion.
Aortic declamping resulted in extracardiac syndecan-1 release and extracardiac heparan sulfate sequestration. Syndecan-1 was sequestered in the coronary circulation during early reperfusion. Glycocalyx has been shown to degrade during cardiac surgery. Besides degradation, glycocalyx has propensity for regeneration. The present results of syndecan-1 and heparan sulfate sequestration may reflect endogenous restoration of the damaged glycocalyx in open heart surgery.</description><subject>Acids</subject><subject>Analysis</subject><subject>Anesthesiology</subject><subject>Anticoagulants</subject><subject>Aorta</subject><subject>Aortic valve</subject><subject>Aspirin</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Blood circulation</subject><subject>Blood vessels</subject><subject>Cardiac patients</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Catheters</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary circulation</subject><subject>Editing</subject><subject>Endothelium</subject><subject>Engineering and Technology</subject><subject>Fibrillation</subject><subject>Glucocorticoids</subject><subject>Glycocalyx</subject><subject>Glycosaminoglycans</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Heart valves</subject><subject>Hemoglobin</subject><subject>Heparan sulfate</subject><subject>Immunosuppressive agents</subject><subject>Intensive care</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Pain</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Proteoglycans</subject><subject>Pulmonary arteries</subject><subject>Reperfusion</subject><subject>Research facilities</subject><subject>Rheumatic heart disease</subject><subject>Surgery</subject><subject>Syndecan</subject><subject>Ventricle</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-A9EBQfRi13zNJHMjlFJ1oVDwo7chm5yZzZJNtsmMdP-9WXdadqQXJhcJJ895k3PyFsVrjOaYcvxpHYbolZtvg4c5IhXmjD8pTnFDyawmiD492p8UL1JaI1RRUdfPixNKmzwqclrcXHoT-hU4q1zZuZ0OWrndXWmGaH1XgopuV0bYQmyHZIMvrS-3qrfg-1QO3kDswh7UKhqrdJmG2EHcvSyetcoleDWuZ8WvL5c_L77Nrq6_Li7Or2a6bkg_I4yQGiMBgjZM1AzzhnICWrUcEahMRTlgimlNxbKllCm-hCVURCy5ripd07Pi7UF360KSY0uSJBlhhPEGZWJxIExQa7mNdqPiTgZl5d9AiJ1UsbfagcRCVcjk13BuWM1BKYMaRhAThAjQNGt9Hm8blhswOjchKjcRnZ54u5Jd-C0FJoLUTRb4MArEcDtA6uXGJg3OKQ9hOLxb4ApXPKPv_kEfr26kOpULsL4N-V69F5Xndf55hjgSmZo_QuVpYGN19k9rc3yS8HGSkJke7vpODSnJxY_v_89e30zZ90fsCpTrVym4oc_OSlOQHUAdQ0oR2ocmYyT39r_vhtzbX472z2lvjj_oIene7_QPe_v-8g</recordid><startdate>20210517</startdate><enddate>20210517</enddate><creator>Passov, 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glycocalyx during early reperfusion in patients undergoing cardiac surgery</title><author>Passov, Arie ; Schramko, Alexey ; Salminen, Ulla-Stina ; Aittomäki, Juha ; Andersson, Sture ; Pesonen, Eero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-24226108e8394864179372ecaf702e5d537e1313638bf334a7bebe528b7c55c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Anesthesiology</topic><topic>Anticoagulants</topic><topic>Aorta</topic><topic>Aortic valve</topic><topic>Aspirin</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Blood circulation</topic><topic>Blood vessels</topic><topic>Cardiac patients</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Catheters</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Passov, Arie</au><au>Schramko, Alexey</au><au>Salminen, Ulla-Stina</au><au>Aittomäki, Juha</au><au>Andersson, Sture</au><au>Pesonen, Eero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-05-17</date><risdate>2021</risdate><volume>16</volume><issue>5</issue><spage>e0251747</spage><epage>e0251747</epage><pages>e0251747-e0251747</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Experimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate. Systemic elevation of syndecan-1 and heparan sulfate is well described in cardiac surgery. Still, the events during immediate reperfusion after aortic declamping are unknown both in the systemic and in the coronary circulation.
In thirty patients undergoing aortic valve replacement, arterial concentrations of syndecan-1 and heparan sulfate were measured immediately before and at one, five and ten minutes after aortic declamping (reperfusion). Parallel blood samples were drawn from the coronary sinus to calculate trans-coronary gradients (coronary sinus-artery).
Compared with immediately before aortic declamping, arterial syndecan-1 increased by 18% [253.8 (151.6-372.0) ng/ml vs. 299.1 (172.0-713.7) ng/ml, p < 0.001] but arterial heparan sulfate decreased by 14% [148.1 (135.7-161.7) ng/ml vs. 128.0 (119.0-138.2) ng/ml, p < 0.001] at one minute after aortic declamping. There was no coronary washout of syndecan-1 or heparan sulfate during reperfusion. On the contrary, trans-coronary sequestration of syndecan-1 occurred at five [-12.96 ng/ml (-36.38-5.15), p = 0.007] and at ten minutes [-12.37 ng/ml (-31.80-6.62), p = 0.049] after reperfusion.
Aortic declamping resulted in extracardiac syndecan-1 release and extracardiac heparan sulfate sequestration. Syndecan-1 was sequestered in the coronary circulation during early reperfusion. Glycocalyx has been shown to degrade during cardiac surgery. Besides degradation, glycocalyx has propensity for regeneration. The present results of syndecan-1 and heparan sulfate sequestration may reflect endogenous restoration of the damaged glycocalyx in open heart surgery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33999952</pmid><doi>10.1371/journal.pone.0251747</doi><tpages>e0251747</tpages><orcidid>https://orcid.org/0000-0002-4126-610X</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Analysis Anesthesiology Anticoagulants Aorta Aortic valve Aspirin Biology and Life Sciences Biomarkers Blood circulation Blood vessels Cardiac patients Cardiovascular disease Care and treatment Catheters Coronary artery Coronary artery disease Coronary circulation Editing Endothelium Engineering and Technology Fibrillation Glucocorticoids Glycocalyx Glycosaminoglycans Heart Heart diseases Heart surgery Heart valves Hemoglobin Heparan sulfate Immunosuppressive agents Intensive care Ischemia Medicine Medicine and Health Sciences Methodology Pain Patients Physical Sciences Plasma Proteins Proteoglycans Pulmonary arteries Reperfusion Research facilities Rheumatic heart disease Surgery Syndecan Ventricle |
| title | Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T05%3A35%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelial%20glycocalyx%20during%20early%20reperfusion%20in%20patients%20undergoing%20cardiac%20surgery&rft.jtitle=PloS%20one&rft.au=Passov,%20Arie&rft.date=2021-05-17&rft.volume=16&rft.issue=5&rft.spage=e0251747&rft.epage=e0251747&rft.pages=e0251747-e0251747&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0251747&rft_dat=%3Cgale_plos_%3EA662040708%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2528424790&rft_id=info:pmid/33999952&rft_galeid=A662040708&rft_doaj_id=oai_doaj_org_article_18a50d08e77d467eaad0942048228ec3&rfr_iscdi=true |