Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype

Although HIV infection inhibits interferon responses in its target cells in vitro, interferon signatures can be detected in vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic cells (pDCs). In this study, we examined the physiological contributions of pDCs to early HIV a...

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Veröffentlicht in:	PLoS pathogens 2021-04, Vol.17 (4), p.e1009522-e1009522
Hauptverfasser:	Tong, Orion, Duette, Gabriel, O'Neil, Thomas R, Royle, Caroline M, Rana, Hafsa, Johnson, Blake, Popovic, Nicole, Dervish, Suat, Brouwer, Michelle A E, Baharlou, Heeva, Patrick, Ellis, Ctercteko, Grahame, Palmer, Sarah, Lee, Eunok, Hunter, Eric, Harman, Andrew N, Cunningham, Anthony L, Nasr, Najla
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral therapy Biology and Life Sciences Blood circulation Care and treatment CCR5 protein CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell culture Cervix Dendritic cells Dendritic Cells - immunology Dendritic Cells - virology Development and progression Effector cells Flow Cytometry Gene expression Genetic aspects Health aspects HIV HIV - genetics HIV - immunology HIV - physiology HIV Core Protein p24 - genetics HIV Core Protein p24 - metabolism HIV infection HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Humans Immunological memory Infections Interferon Interferon-alpha - metabolism Latency Lymphocytes Lymphocytes T Macrophages Medicine and Health Sciences Memory cells Myeloid Cells - immunology Myeloid Cells - virology Pathogens Phenotype Phenotypes Rank tests Research and Analysis Methods Retention Viral infections Viral proteins Viruses α-Interferon
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