The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans

Intestinal epithelial cells are subject to attack by a diverse array of microbes, including intracellular as well as extracellular pathogens. While defense in epithelial cells can be triggered by pattern recognition receptor-mediated detection of microbe-associated molecular patterns, there is much...

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Veröffentlicht in:	PLoS pathogens 2021-04, Vol.17 (4), p.e1009350-e1009350
Hauptverfasser:	Tecle, Eillen, Chhan, Crystal B, Franklin, Latisha, Underwood, Ryan S, Hanna-Rose, Wendy, Troemel, Emily R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Bacteria Bacterial diseases Bacterial infections Bacterial Infections - prevention & control Biology and Life Sciences Caenorhabditis elegans Caenorhabditis elegans - metabolism Cell Count - methods Disease resistance Drug resistance in microorganisms Epithelial cells Epithelial Cells - metabolism Epithelium Experiments Gene expression Genes Genomes HIV Host-bacteria relationships Human immunodeficiency virus Immunological tolerance Infections Kinases Medicine and Health Sciences Metabolites Mutants Mutation Nucleosides Nucleotides Pathogens Phenotypes Phosphorylase Physical Sciences Physiological aspects Pseudomonas aeruginosa Purine Nucleosides - metabolism Purine-Nucleoside Phosphorylase - deficiency Purine-Nucleoside Phosphorylase - genetics Purines Receptors, Pattern Recognition - metabolism Research and Analysis Methods Vertebrates Viruses
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