Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expen...
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| description | Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth. |
| doi_str_mv | 10.1371/journal.pone.0251803 |
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Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. 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microbiota profiles of young South Indian children: Child sex-specific relations with growth</title><author>Shivakumar, Nirupama ; Sivadas, Ambily ; Devi, Sarita ; Jahoor, Farook ; McLaughlin, John ; Smith, Craig P ; Kurpad, Anura V ; Mukhopadhyay, Arpita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-cc2b9f7be5b0b027506a64e98243c0c78519a7426b49f20fe344c429938d61813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Agricultural research</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Body composition</topic><topic>Body weight</topic><topic>Child development</topic><topic>Children</topic><topic>Children & youth</topic><topic>Demographic variables</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Digestibility</topic><topic>Digestive system</topic><topic>Digestive tract</topic><topic>Drafting 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Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. 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| subjects | Age Agricultural research Biology Biology and Life Sciences Body composition Body weight Child development Children Children & youth Demographic variables Diabetes Diabetes mellitus Digestibility Digestive system Digestive tract Drafting software Drug dosages Editing Endocrinology Energy expenditure Feces Funding Gastroenterology Gastrointestinal tract Growth disorders Health aspects Health sciences Hospitals Intestinal microflora Intestine Malnutrition in children Medicine Medicine and Health Sciences Metabolism Methodology Microbiomes Microbiota Microbiota (Symbiotic organisms) Nutrition Nutrition research Nutritional status Pediatric research Pediatrics People and Places Permeability Physical Sciences Protein turnover Research and Analysis Methods Research facilities Reviews Risk factors Slums Tryptophan Urine Visualization |
| title | Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth |
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