Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol

Background Opioid therapy is utilized for a broad range of chronic pain conditions. Several studies have highlighted the adverse effects of opioid medication due to the misuse of these drugs. The gradual increase in the use of opioids has become a global phenomenon and is generating social concern....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2021-05, Vol.16 (5), p.e0251586, Article 0251586
Hauptverfasser: Ramirez-Maestre, Carmen, Lopez-Martinez, Alicia E., Esteve, Rosa
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 5
container_start_page e0251586
container_title PloS one
container_volume 16
creator Ramirez-Maestre, Carmen
Lopez-Martinez, Alicia E.
Esteve, Rosa
description Background Opioid therapy is utilized for a broad range of chronic pain conditions. Several studies have highlighted the adverse effects of opioid medication due to the misuse of these drugs. The gradual increase in the use of opioids has become a global phenomenon and is generating social concern. Several treatment guidelines have strongly recommended assessing the risks and benefits of pharmacological treatment with opioids. These guidelines also recommend the psychological assessment of patients with chronic noncancer pain in order to make informed decisions on the advisability of intervention with opioids. Some authors have emphasized the relevance of assessing the risk of opioid misuse in patients with noncancer chronic pain before initiating treatment. Methods and analysis Two studies will be conducted, each with a different primary objective. The primary objective of the first study (Study 1) will be to conduct a comprehensive investigation to identify the factors most closely associated with subsequent opioid misuse; and based on the results of Study 1, the primary objective of the second study (Study 2) will be to develop a brief, reliable, valid, and useful instrument that would enable health care providers to make decisions on opioid prescription and on the required level of monitoring and follow-up. These decisions would have positive consequences for patient wellbeing. Study 1 will include a logistic regression analysis to test the hypothetical model. Study 2 will have a longitudinal design and include three assessment sessions in order to develop a measure to assess the risk of prescribed opioid misuse and to analyse its reliability and validity. Participants will be individuals with chronic noncancer pain attending three Pain Units. These individuals will either be undergoing pharmacological treatment that includes opioid analgesics (Study 1, N = 400) or are going to commence such treatment (Study 2, N = 250).
doi_str_mv 10.1371/journal.pone.0251586
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2526806387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A661690381</galeid><doaj_id>oai_doaj_org_article_18a732c230d542458f5a60bb6f30e1ca</doaj_id><sourcerecordid>A661690381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-7a2ab260aad743e4177f0bd57d9f302bce26e4141bd6f883ef87cd897ad33ad3</originalsourceid><addsrcrecordid>eNqNk-2KEzEUhgdR3HX1DkQDgiDSmo-ZTOoPodSvwsKKLv4NmeRMm3WajEmmq1fjrZpuu6UFhWUYJpw875vDOzlF8ZTgMWE1eXPlh-BUN-69gzGmFakEv1eckgmjI04xu3-wPikexXiFccUE5w-LE8YmosSsPi3-fAlgrE52DWitglVNBxH5FvUBog62T9Y75HvrrUErG4cIyDrUq2TBpYiubVoivQzeWY2cd1o5DSHvWzdG72ENne9XmdxYKhRs_IEMJNA3tlGrDt6iKQqwsDFBbiUvex9SPt4nr333uHjQqi7Ck933rLj8-OFy9nl0fvFpPpuejzSf0DSqFVUN5VgpU5cMSlLXLW5MVZtJyzBtNFCeqyVpDG-FYNCKWhsxqZVhLL9nxfOtbd_5KHfRRkkrygXmTNSZmG8J49WV7INdqfBbemXlTcGHhVQhWd2BJELVjGrKsKlKWlairRTHTcNzK0C0yl7vdqcNzQqMzvkE1R2ZHu84u5QLv5aCEMHoppkXO4Pgfw4Q039a3lGLHLO0rvXZTOefqOWUc8InmAmSqfE_qPwYWFmdL1drc_1I8OpIkJkEv9JCDTHK-bevd2cvvh-zLw_YJaguLaPvhs1VicdguQV18DEGaPfJESw3s3GbhtzMhtzNRpY9O0x9L7odhgyILXANjW-jzjdcwx7DGHNeciooxgTjmU1q09nMDy5l6eu7S9lfp5cuLA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2526806387</pqid></control><display><type>article</type><title>Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>Web of Science - Science Citation Index Expanded - 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Web of Science - Social Sciences Citation Index – 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><source>Free Full-Text Journals in Chemistry</source><creator>Ramirez-Maestre, Carmen ; Lopez-Martinez, Alicia E. ; Esteve, Rosa</creator><contributor>Suppiah, Vijayaprakash</contributor><creatorcontrib>Ramirez-Maestre, Carmen ; Lopez-Martinez, Alicia E. ; Esteve, Rosa ; Suppiah, Vijayaprakash</creatorcontrib><description>Background Opioid therapy is utilized for a broad range of chronic pain conditions. Several studies have highlighted the adverse effects of opioid medication due to the misuse of these drugs. The gradual increase in the use of opioids has become a global phenomenon and is generating social concern. Several treatment guidelines have strongly recommended assessing the risks and benefits of pharmacological treatment with opioids. These guidelines also recommend the psychological assessment of patients with chronic noncancer pain in order to make informed decisions on the advisability of intervention with opioids. Some authors have emphasized the relevance of assessing the risk of opioid misuse in patients with noncancer chronic pain before initiating treatment. Methods and analysis Two studies will be conducted, each with a different primary objective. The primary objective of the first study (Study 1) will be to conduct a comprehensive investigation to identify the factors most closely associated with subsequent opioid misuse; and based on the results of Study 1, the primary objective of the second study (Study 2) will be to develop a brief, reliable, valid, and useful instrument that would enable health care providers to make decisions on opioid prescription and on the required level of monitoring and follow-up. These decisions would have positive consequences for patient wellbeing. Study 1 will include a logistic regression analysis to test the hypothetical model. Study 2 will have a longitudinal design and include three assessment sessions in order to develop a measure to assess the risk of prescribed opioid misuse and to analyse its reliability and validity. Participants will be individuals with chronic noncancer pain attending three Pain Units. These individuals will either be undergoing pharmacological treatment that includes opioid analgesics (Study 1, N = 400) or are going to commence such treatment (Study 2, N = 250).</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0251586</identifier><identifier>PMID: 33984037</identifier><language>eng</language><publisher>SAN FRANCISCO: Public Library Science</publisher><subject>Analgesics ; Anxiety ; Biology and Life Sciences ; Care and treatment ; Chronic pain ; Drug dosages ; Drug therapy ; Engineering and Technology ; Gender aspects ; Health risks ; Hypotheses ; Impulsivity ; Medicine and Health Sciences ; Multidisciplinary Sciences ; Narcotics ; Opioids ; Pain ; Post traumatic stress disorder ; Registered Report Protocol ; Regression analysis ; Risk assessment ; Science &amp; Technology ; Science &amp; Technology - Other Topics ; Sex differences ; Social Sciences ; Variables</subject><ispartof>PloS one, 2021-05, Vol.16 (5), p.e0251586, Article 0251586</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Ramírez-Maestre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Ramírez-Maestre et al 2021 Ramírez-Maestre et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000664628200100</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c692t-7a2ab260aad743e4177f0bd57d9f302bce26e4141bd6f883ef87cd897ad33ad3</citedby><cites>FETCH-LOGICAL-c692t-7a2ab260aad743e4177f0bd57d9f302bce26e4141bd6f883ef87cd897ad33ad3</cites><orcidid>0000-0002-3245-7844 ; 0000-0003-4038-7863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118327/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118327/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,2929,23871,27929,27930,39262,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33984037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Suppiah, Vijayaprakash</contributor><creatorcontrib>Ramirez-Maestre, Carmen</creatorcontrib><creatorcontrib>Lopez-Martinez, Alicia E.</creatorcontrib><creatorcontrib>Esteve, Rosa</creatorcontrib><title>Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol</title><title>PloS one</title><addtitle>PLOS ONE</addtitle><addtitle>PLoS One</addtitle><description>Background Opioid therapy is utilized for a broad range of chronic pain conditions. Several studies have highlighted the adverse effects of opioid medication due to the misuse of these drugs. The gradual increase in the use of opioids has become a global phenomenon and is generating social concern. Several treatment guidelines have strongly recommended assessing the risks and benefits of pharmacological treatment with opioids. These guidelines also recommend the psychological assessment of patients with chronic noncancer pain in order to make informed decisions on the advisability of intervention with opioids. Some authors have emphasized the relevance of assessing the risk of opioid misuse in patients with noncancer chronic pain before initiating treatment. Methods and analysis Two studies will be conducted, each with a different primary objective. The primary objective of the first study (Study 1) will be to conduct a comprehensive investigation to identify the factors most closely associated with subsequent opioid misuse; and based on the results of Study 1, the primary objective of the second study (Study 2) will be to develop a brief, reliable, valid, and useful instrument that would enable health care providers to make decisions on opioid prescription and on the required level of monitoring and follow-up. These decisions would have positive consequences for patient wellbeing. Study 1 will include a logistic regression analysis to test the hypothetical model. Study 2 will have a longitudinal design and include three assessment sessions in order to develop a measure to assess the risk of prescribed opioid misuse and to analyse its reliability and validity. Participants will be individuals with chronic noncancer pain attending three Pain Units. These individuals will either be undergoing pharmacological treatment that includes opioid analgesics (Study 1, N = 400) or are going to commence such treatment (Study 2, N = 250).</description><subject>Analgesics</subject><subject>Anxiety</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Chronic pain</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Engineering and Technology</subject><subject>Gender aspects</subject><subject>Health risks</subject><subject>Hypotheses</subject><subject>Impulsivity</subject><subject>Medicine and Health Sciences</subject><subject>Multidisciplinary Sciences</subject><subject>Narcotics</subject><subject>Opioids</subject><subject>Pain</subject><subject>Post traumatic stress disorder</subject><subject>Registered Report Protocol</subject><subject>Regression analysis</subject><subject>Risk assessment</subject><subject>Science &amp; Technology</subject><subject>Science &amp; Technology - Other Topics</subject><subject>Sex differences</subject><subject>Social Sciences</subject><subject>Variables</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk-2KEzEUhgdR3HX1DkQDgiDSmo-ZTOoPodSvwsKKLv4NmeRMm3WajEmmq1fjrZpuu6UFhWUYJpw875vDOzlF8ZTgMWE1eXPlh-BUN-69gzGmFakEv1eckgmjI04xu3-wPikexXiFccUE5w-LE8YmosSsPi3-fAlgrE52DWitglVNBxH5FvUBog62T9Y75HvrrUErG4cIyDrUq2TBpYiubVoivQzeWY2cd1o5DSHvWzdG72ENne9XmdxYKhRs_IEMJNA3tlGrDt6iKQqwsDFBbiUvex9SPt4nr333uHjQqi7Ck933rLj8-OFy9nl0fvFpPpuejzSf0DSqFVUN5VgpU5cMSlLXLW5MVZtJyzBtNFCeqyVpDG-FYNCKWhsxqZVhLL9nxfOtbd_5KHfRRkkrygXmTNSZmG8J49WV7INdqfBbemXlTcGHhVQhWd2BJELVjGrKsKlKWlairRTHTcNzK0C0yl7vdqcNzQqMzvkE1R2ZHu84u5QLv5aCEMHoppkXO4Pgfw4Q039a3lGLHLO0rvXZTOefqOWUc8InmAmSqfE_qPwYWFmdL1drc_1I8OpIkJkEv9JCDTHK-bevd2cvvh-zLw_YJaguLaPvhs1VicdguQV18DEGaPfJESw3s3GbhtzMhtzNRpY9O0x9L7odhgyILXANjW-jzjdcwx7DGHNeciooxgTjmU1q09nMDy5l6eu7S9lfp5cuLA</recordid><startdate>20210513</startdate><enddate>20210513</enddate><creator>Ramirez-Maestre, Carmen</creator><creator>Lopez-Martinez, Alicia E.</creator><creator>Esteve, Rosa</creator><general>Public Library Science</general><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3245-7844</orcidid><orcidid>https://orcid.org/0000-0003-4038-7863</orcidid></search><sort><creationdate>20210513</creationdate><title>Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol</title><author>Ramirez-Maestre, Carmen ; Lopez-Martinez, Alicia E. ; Esteve, Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7a2ab260aad743e4177f0bd57d9f302bce26e4141bd6f883ef87cd897ad33ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analgesics</topic><topic>Anxiety</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Chronic pain</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Engineering and Technology</topic><topic>Gender aspects</topic><topic>Health risks</topic><topic>Hypotheses</topic><topic>Impulsivity</topic><topic>Medicine and Health Sciences</topic><topic>Multidisciplinary Sciences</topic><topic>Narcotics</topic><topic>Opioids</topic><topic>Pain</topic><topic>Post traumatic stress disorder</topic><topic>Registered Report Protocol</topic><topic>Regression analysis</topic><topic>Risk assessment</topic><topic>Science &amp; Technology</topic><topic>Science &amp; Technology - Other Topics</topic><topic>Sex differences</topic><topic>Social Sciences</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramirez-Maestre, Carmen</creatorcontrib><creatorcontrib>Lopez-Martinez, Alicia E.</creatorcontrib><creatorcontrib>Esteve, Rosa</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI &amp; AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramirez-Maestre, Carmen</au><au>Lopez-Martinez, Alicia E.</au><au>Esteve, Rosa</au><au>Suppiah, Vijayaprakash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol</atitle><jtitle>PloS one</jtitle><stitle>PLOS ONE</stitle><addtitle>PLoS One</addtitle><date>2021-05-13</date><risdate>2021</risdate><volume>16</volume><issue>5</issue><spage>e0251586</spage><pages>e0251586-</pages><artnum>0251586</artnum><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background Opioid therapy is utilized for a broad range of chronic pain conditions. Several studies have highlighted the adverse effects of opioid medication due to the misuse of these drugs. The gradual increase in the use of opioids has become a global phenomenon and is generating social concern. Several treatment guidelines have strongly recommended assessing the risks and benefits of pharmacological treatment with opioids. These guidelines also recommend the psychological assessment of patients with chronic noncancer pain in order to make informed decisions on the advisability of intervention with opioids. Some authors have emphasized the relevance of assessing the risk of opioid misuse in patients with noncancer chronic pain before initiating treatment. Methods and analysis Two studies will be conducted, each with a different primary objective. The primary objective of the first study (Study 1) will be to conduct a comprehensive investigation to identify the factors most closely associated with subsequent opioid misuse; and based on the results of Study 1, the primary objective of the second study (Study 2) will be to develop a brief, reliable, valid, and useful instrument that would enable health care providers to make decisions on opioid prescription and on the required level of monitoring and follow-up. These decisions would have positive consequences for patient wellbeing. Study 1 will include a logistic regression analysis to test the hypothetical model. Study 2 will have a longitudinal design and include three assessment sessions in order to develop a measure to assess the risk of prescribed opioid misuse and to analyse its reliability and validity. Participants will be individuals with chronic noncancer pain attending three Pain Units. These individuals will either be undergoing pharmacological treatment that includes opioid analgesics (Study 1, N = 400) or are going to commence such treatment (Study 2, N = 250).</abstract><cop>SAN FRANCISCO</cop><pub>Public Library Science</pub><pmid>33984037</pmid><doi>10.1371/journal.pone.0251586</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-3245-7844</orcidid><orcidid>https://orcid.org/0000-0003-4038-7863</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2021-05, Vol.16 (5), p.e0251586, Article 0251586
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2526806387
source DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Web of Science - Social Sciences Citation Index – 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Free Full-Text Journals in Chemistry
subjects Analgesics
Anxiety
Biology and Life Sciences
Care and treatment
Chronic pain
Drug dosages
Drug therapy
Engineering and Technology
Gender aspects
Health risks
Hypotheses
Impulsivity
Medicine and Health Sciences
Multidisciplinary Sciences
Narcotics
Opioids
Pain
Post traumatic stress disorder
Registered Report Protocol
Regression analysis
Risk assessment
Science & Technology
Science & Technology - Other Topics
Sex differences
Social Sciences
Variables
title Predictive variables of prescription opioid misuse in patients with chronic noncancer pain. Development of a risk detection scale: A registered report protocol
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-10T11%3A16%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictive%20variables%20of%20prescription%20opioid%20misuse%20in%20patients%20with%20chronic%20noncancer%20pain.%20Development%20of%20a%20risk%20detection%20scale:%20A%20registered%20report%20protocol&rft.jtitle=PloS%20one&rft.au=Ramirez-Maestre,%20Carmen&rft.date=2021-05-13&rft.volume=16&rft.issue=5&rft.spage=e0251586&rft.pages=e0251586-&rft.artnum=0251586&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0251586&rft_dat=%3Cgale_plos_%3EA661690381%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2526806387&rft_id=info:pmid/33984037&rft_galeid=A661690381&rft_doaj_id=oai_doaj_org_article_18a732c230d542458f5a60bb6f30e1ca&rfr_iscdi=true