Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis

Atherosclerotic vascular disease resulting from unstable plaques is the leading cause of morbidity and mortality in subjects with type 2 diabetes (T2D), and thus a major therapeutic goal is to discover T2D drugs that can also promote atherosclerotic plaque stability. Genetic or pharmacologic inhibit...

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Veröffentlicht in:	PloS one 2021-05, Vol.16 (5), p.e0246600
Hauptverfasser:	Ozcan, Lale, Kasikara, Canan, Yurdagul, Jr, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H, Tabas, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Allosteric Regulation - drug effects Animal models Animals Aorta - pathology Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - enzymology Atherosclerosis - pathology Biology and Life Sciences Biophysics Blood glucose Ca2+/calmodulin-dependent protein kinase II Care and treatment Cholesterol Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Drug dosages Editing Epidemics Glucose Glucose - metabolism Health aspects Health care facilities Homeostasis - drug effects Hyperglycemia Insulin Insulin resistance Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Kinases Lipids - blood Male Mass spectra Mass spectrometry Medicine Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Necrosis Obesity Pathogenesis Pharmacology, Experimental Physiological aspects Physiology Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - enzymology Plaque, Atherosclerotic - pathology Plasma Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - pharmacology Protein kinases Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Proteins Public health Quadrupoles Reviews Trifluoroacetic acid
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