Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy

Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gene expression within tumor biopsies, collected befo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2021-05, Vol.16 (5), p.e0251163-e0251163
Hauptverfasser:	Zoeller, Jason J, Press, Michael F, Selfors, Laura M, Dering, Judy, Slamon, Dennis J, Hurvitz, Sara A, Brugge, Joan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bcl-2 protein Biology Biology and Life Sciences Biopsy Breast cancer Cancer Cancer therapies Clinical trials Data analysis Drug resistance Editing ErbB-2 protein Funding Geffen, David Gene expression Hematology Informed consent Medical research Medicine Medicine and Health Sciences Methodology Oncology Pathology Patients Phenotypes Proteins Research and Analysis Methods Review boards Tumors Visualization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!