Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy
The hypothalamic-pituitary-adrenal axis, with cortisol as its final metabolite, has been proposed as a potential underlying biological mechanism for associations between depression and stress symptoms during pregnancy and adverse perinatal outcomes. In this study, we explored associations between sa...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0250459-e0250459 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0250459 |
|---|---|
| container_issue | 4 |
| container_start_page | e0250459 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Vlenterie, Richelle Geuijen, Pauline M van Gelder, Marleen M H J Roeleveld, Nel |
| description | The hypothalamic-pituitary-adrenal axis, with cortisol as its final metabolite, has been proposed as a potential underlying biological mechanism for associations between depression and stress symptoms during pregnancy and adverse perinatal outcomes. In this study, we explored associations between salivary cortisol as a potential biomarker for stress and depressive symptoms and several self-completed psychological measurement scales among pregnant women. In total, 652 pregnant women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study completed the Edinburgh Depression Scale (EDS), Patient Health Questionnaire-2 (PHQ-2), Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R), and Tilburg Pregnancy Distress Scale (TPDS) and collected a single awakening salivary cortisol sample around gestational week 17. Odds ratios, Spearman's correlation coefficients (ρs) and Cohen's Kappa coefficients (κ) were calculated to examine the associations between the EDS, PHQ-2, PRAQ-R, TPDS, and maternal cortisol levels. The overall correlation coefficient between the score on the EDS and the salivary cortisol level was 0.01 (p = 0.89) with κ = -0.01 (95% confidence interval [CI] -0.08-0.06). We did not observe agreement between the PHQ-2 and cortisol levels either (κ = 0.06 (95% CI -0.02-0.14)). The results for the PRAQ-R and TPDS were similar with overall correlations with maternal cortisol levels of ρs = 0.01 (p = 0.81) and ρs = 0.06 (p = 0.35) and agreements of κ = 0.02 (95% CI -0.06-0.09) and κ = -0.02 (95% CI -0.11-0.07), respectively. Maternal awakening salivary cortisol levels and measures of maternal psychological distress, anxiety, depressive symptoms, and pregnancy-related anxiety, assessed by self-completed questionnaires, did not seem to be related in mid-pregnancy. |
| doi_str_mv | 10.1371/journal.pone.0250459 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2517338908</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A659472751</galeid><doaj_id>oai_doaj_org_article_e4e7e676b7f64b4e89d4c687db79a060</doaj_id><sourcerecordid>A659472751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c688t-8d7fe75286f9ff9913aad682d86030fe4e4d65dae09060b91c05b7410fe33b693</originalsourceid><addsrcrecordid>eNqNkktr3DAUhU1paNK0_6C0hkJpFjOVLFmPTSGEPgYCoa9shWxdz2iwpalkh-bfV844YVyyKF5Ylr5zru71ybJXGC0x4fjD1g_B6Xa58w6WqCgRLeWT7ARLUixYgcjTg_Vx9jzGLUIlEYw9y44JERIzWp5k198GiL31zmkbIObamTzq1t7ocJvXPvQ2-jbvfd6BjkOAPPYJ23MGduM6iXPr8s6aRfpeO-3q2xfZUaPbCC-n92n26_OnnxdfF5dXX1YX55eLmgnRL4ThDfCyEKyRTSMlJlobJgojGCKoAQrUsNJoQBIxVElco7LiFKcjQiomyWn2Zu-7a31U00iiKkrMxx6RSMRqTxivt2oXbJc6U15bdbfhw1rp1GXdgkrlODDOKt4wWlEQ0tB0T24qLnWqn7w-TtWGqgNTg-uDbmem8xNnN2rtb5RAadi0TAbvJ4Pgf4-DV52NNbStduCHu3uLArOCjrXe_oM-3t1ErXVqwLrGp7r1aKrOWSkpL3iJE7V8hEqPgc7WKT-NTfszwdlMkJge_vRrPcSoVj--_z97dT1n3x2wG9Btv0n5GsYAxjlI92AdfIwBmochY6TG-N9PQ43xV1P8k-z14Q96EN3nnfwFAVcATA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2517338908</pqid></control><display><type>article</type><title>Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Vlenterie, Richelle ; Geuijen, Pauline M ; van Gelder, Marleen M H J ; Roeleveld, Nel</creator><contributor>Crispi, Fàtima</contributor><creatorcontrib>Vlenterie, Richelle ; Geuijen, Pauline M ; van Gelder, Marleen M H J ; Roeleveld, Nel ; Crispi, Fàtima</creatorcontrib><description>The hypothalamic-pituitary-adrenal axis, with cortisol as its final metabolite, has been proposed as a potential underlying biological mechanism for associations between depression and stress symptoms during pregnancy and adverse perinatal outcomes. In this study, we explored associations between salivary cortisol as a potential biomarker for stress and depressive symptoms and several self-completed psychological measurement scales among pregnant women. In total, 652 pregnant women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study completed the Edinburgh Depression Scale (EDS), Patient Health Questionnaire-2 (PHQ-2), Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R), and Tilburg Pregnancy Distress Scale (TPDS) and collected a single awakening salivary cortisol sample around gestational week 17. Odds ratios, Spearman's correlation coefficients (ρs) and Cohen's Kappa coefficients (κ) were calculated to examine the associations between the EDS, PHQ-2, PRAQ-R, TPDS, and maternal cortisol levels. The overall correlation coefficient between the score on the EDS and the salivary cortisol level was 0.01 (p = 0.89) with κ = -0.01 (95% confidence interval [CI] -0.08-0.06). We did not observe agreement between the PHQ-2 and cortisol levels either (κ = 0.06 (95% CI -0.02-0.14)). The results for the PRAQ-R and TPDS were similar with overall correlations with maternal cortisol levels of ρs = 0.01 (p = 0.81) and ρs = 0.06 (p = 0.35) and agreements of κ = 0.02 (95% CI -0.06-0.09) and κ = -0.02 (95% CI -0.11-0.07), respectively. Maternal awakening salivary cortisol levels and measures of maternal psychological distress, anxiety, depressive symptoms, and pregnancy-related anxiety, assessed by self-completed questionnaires, did not seem to be related in mid-pregnancy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0250459</identifier><identifier>PMID: 33891645</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anxieties ; Anxiety ; Biology and Life Sciences ; Biomarkers ; Cognition ; Complications and side effects ; Data analysis ; Demographic aspects ; Depression, Mental ; Disorders ; Editing ; Funding ; Genetic aspects ; Health care facilities ; Health sciences ; Hormones ; Hydrocortisone ; Medicine and Health Sciences ; Mental depression ; Mood ; Physiological aspects ; Pregnancy ; Pregnant women ; Psychiatry ; Psychological aspects ; Questionnaires ; Research and Analysis Methods ; Reviews ; Risk factors ; Saliva ; Salivary glands ; secretions ; Signs and symptoms ; Social Sciences ; Stress ; Stress (Psychology) ; Womens health</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0250459-e0250459</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Vlenterie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Vlenterie et al 2021 Vlenterie et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c688t-8d7fe75286f9ff9913aad682d86030fe4e4d65dae09060b91c05b7410fe33b693</citedby><cites>FETCH-LOGICAL-c688t-8d7fe75286f9ff9913aad682d86030fe4e4d65dae09060b91c05b7410fe33b693</cites><orcidid>0000-0003-4853-4434 ; 0000-0001-9299-3860</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064545/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064545/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33891645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Crispi, Fàtima</contributor><creatorcontrib>Vlenterie, Richelle</creatorcontrib><creatorcontrib>Geuijen, Pauline M</creatorcontrib><creatorcontrib>van Gelder, Marleen M H J</creatorcontrib><creatorcontrib>Roeleveld, Nel</creatorcontrib><title>Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The hypothalamic-pituitary-adrenal axis, with cortisol as its final metabolite, has been proposed as a potential underlying biological mechanism for associations between depression and stress symptoms during pregnancy and adverse perinatal outcomes. In this study, we explored associations between salivary cortisol as a potential biomarker for stress and depressive symptoms and several self-completed psychological measurement scales among pregnant women. In total, 652 pregnant women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study completed the Edinburgh Depression Scale (EDS), Patient Health Questionnaire-2 (PHQ-2), Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R), and Tilburg Pregnancy Distress Scale (TPDS) and collected a single awakening salivary cortisol sample around gestational week 17. Odds ratios, Spearman's correlation coefficients (ρs) and Cohen's Kappa coefficients (κ) were calculated to examine the associations between the EDS, PHQ-2, PRAQ-R, TPDS, and maternal cortisol levels. The overall correlation coefficient between the score on the EDS and the salivary cortisol level was 0.01 (p = 0.89) with κ = -0.01 (95% confidence interval [CI] -0.08-0.06). We did not observe agreement between the PHQ-2 and cortisol levels either (κ = 0.06 (95% CI -0.02-0.14)). The results for the PRAQ-R and TPDS were similar with overall correlations with maternal cortisol levels of ρs = 0.01 (p = 0.81) and ρs = 0.06 (p = 0.35) and agreements of κ = 0.02 (95% CI -0.06-0.09) and κ = -0.02 (95% CI -0.11-0.07), respectively. Maternal awakening salivary cortisol levels and measures of maternal psychological distress, anxiety, depressive symptoms, and pregnancy-related anxiety, assessed by self-completed questionnaires, did not seem to be related in mid-pregnancy.</description><subject>Anxieties</subject><subject>Anxiety</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cognition</subject><subject>Complications and side effects</subject><subject>Data analysis</subject><subject>Demographic aspects</subject><subject>Depression, Mental</subject><subject>Disorders</subject><subject>Editing</subject><subject>Funding</subject><subject>Genetic aspects</subject><subject>Health care facilities</subject><subject>Health sciences</subject><subject>Hormones</subject><subject>Hydrocortisone</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Mood</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Questionnaires</subject><subject>Research and Analysis Methods</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Saliva</subject><subject>Salivary glands</subject><subject>secretions</subject><subject>Signs and symptoms</subject><subject>Social Sciences</subject><subject>Stress</subject><subject>Stress (Psychology)</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktr3DAUhU1paNK0_6C0hkJpFjOVLFmPTSGEPgYCoa9shWxdz2iwpalkh-bfV844YVyyKF5Ylr5zru71ybJXGC0x4fjD1g_B6Xa58w6WqCgRLeWT7ARLUixYgcjTg_Vx9jzGLUIlEYw9y44JERIzWp5k198GiL31zmkbIObamTzq1t7ocJvXPvQ2-jbvfd6BjkOAPPYJ23MGduM6iXPr8s6aRfpeO-3q2xfZUaPbCC-n92n26_OnnxdfF5dXX1YX55eLmgnRL4ThDfCyEKyRTSMlJlobJgojGCKoAQrUsNJoQBIxVElco7LiFKcjQiomyWn2Zu-7a31U00iiKkrMxx6RSMRqTxivt2oXbJc6U15bdbfhw1rp1GXdgkrlODDOKt4wWlEQ0tB0T24qLnWqn7w-TtWGqgNTg-uDbmem8xNnN2rtb5RAadi0TAbvJ4Pgf4-DV52NNbStduCHu3uLArOCjrXe_oM-3t1ErXVqwLrGp7r1aKrOWSkpL3iJE7V8hEqPgc7WKT-NTfszwdlMkJge_vRrPcSoVj--_z97dT1n3x2wG9Btv0n5GsYAxjlI92AdfIwBmochY6TG-N9PQ43xV1P8k-z14Q96EN3nnfwFAVcATA</recordid><startdate>20210423</startdate><enddate>20210423</enddate><creator>Vlenterie, Richelle</creator><creator>Geuijen, Pauline M</creator><creator>van Gelder, Marleen M H J</creator><creator>Roeleveld, Nel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4853-4434</orcidid><orcidid>https://orcid.org/0000-0001-9299-3860</orcidid></search><sort><creationdate>20210423</creationdate><title>Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy</title><author>Vlenterie, Richelle ; Geuijen, Pauline M ; van Gelder, Marleen M H J ; Roeleveld, Nel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c688t-8d7fe75286f9ff9913aad682d86030fe4e4d65dae09060b91c05b7410fe33b693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anxieties</topic><topic>Anxiety</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Cognition</topic><topic>Complications and side effects</topic><topic>Data analysis</topic><topic>Demographic aspects</topic><topic>Depression, Mental</topic><topic>Disorders</topic><topic>Editing</topic><topic>Funding</topic><topic>Genetic aspects</topic><topic>Health care facilities</topic><topic>Health sciences</topic><topic>Hormones</topic><topic>Hydrocortisone</topic><topic>Medicine and Health Sciences</topic><topic>Mental depression</topic><topic>Mood</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Questionnaires</topic><topic>Research and Analysis Methods</topic><topic>Reviews</topic><topic>Risk factors</topic><topic>Saliva</topic><topic>Salivary glands</topic><topic>secretions</topic><topic>Signs and symptoms</topic><topic>Social Sciences</topic><topic>Stress</topic><topic>Stress (Psychology)</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vlenterie, Richelle</creatorcontrib><creatorcontrib>Geuijen, Pauline M</creatorcontrib><creatorcontrib>van Gelder, Marleen M H J</creatorcontrib><creatorcontrib>Roeleveld, Nel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vlenterie, Richelle</au><au>Geuijen, Pauline M</au><au>van Gelder, Marleen M H J</au><au>Roeleveld, Nel</au><au>Crispi, Fàtima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-04-23</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0250459</spage><epage>e0250459</epage><pages>e0250459-e0250459</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The hypothalamic-pituitary-adrenal axis, with cortisol as its final metabolite, has been proposed as a potential underlying biological mechanism for associations between depression and stress symptoms during pregnancy and adverse perinatal outcomes. In this study, we explored associations between salivary cortisol as a potential biomarker for stress and depressive symptoms and several self-completed psychological measurement scales among pregnant women. In total, 652 pregnant women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study completed the Edinburgh Depression Scale (EDS), Patient Health Questionnaire-2 (PHQ-2), Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R), and Tilburg Pregnancy Distress Scale (TPDS) and collected a single awakening salivary cortisol sample around gestational week 17. Odds ratios, Spearman's correlation coefficients (ρs) and Cohen's Kappa coefficients (κ) were calculated to examine the associations between the EDS, PHQ-2, PRAQ-R, TPDS, and maternal cortisol levels. The overall correlation coefficient between the score on the EDS and the salivary cortisol level was 0.01 (p = 0.89) with κ = -0.01 (95% confidence interval [CI] -0.08-0.06). We did not observe agreement between the PHQ-2 and cortisol levels either (κ = 0.06 (95% CI -0.02-0.14)). The results for the PRAQ-R and TPDS were similar with overall correlations with maternal cortisol levels of ρs = 0.01 (p = 0.81) and ρs = 0.06 (p = 0.35) and agreements of κ = 0.02 (95% CI -0.06-0.09) and κ = -0.02 (95% CI -0.11-0.07), respectively. Maternal awakening salivary cortisol levels and measures of maternal psychological distress, anxiety, depressive symptoms, and pregnancy-related anxiety, assessed by self-completed questionnaires, did not seem to be related in mid-pregnancy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33891645</pmid><doi>10.1371/journal.pone.0250459</doi><tpages>e0250459</tpages><orcidid>https://orcid.org/0000-0003-4853-4434</orcidid><orcidid>https://orcid.org/0000-0001-9299-3860</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-04, Vol.16 (4), p.e0250459-e0250459 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2517338908 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anxieties Anxiety Biology and Life Sciences Biomarkers Cognition Complications and side effects Data analysis Demographic aspects Depression, Mental Disorders Editing Funding Genetic aspects Health care facilities Health sciences Hormones Hydrocortisone Medicine and Health Sciences Mental depression Mood Physiological aspects Pregnancy Pregnant women Psychiatry Psychological aspects Questionnaires Research and Analysis Methods Reviews Risk factors Saliva Salivary glands secretions Signs and symptoms Social Sciences Stress Stress (Psychology) Womens health |
| title | Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T06%3A20%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Questionnaires%20and%20salivary%20cortisol%20to%20measure%20stress%20and%20depression%20in%20mid-pregnancy&rft.jtitle=PloS%20one&rft.au=Vlenterie,%20Richelle&rft.date=2021-04-23&rft.volume=16&rft.issue=4&rft.spage=e0250459&rft.epage=e0250459&rft.pages=e0250459-e0250459&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0250459&rft_dat=%3Cgale_plos_%3EA659472751%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2517338908&rft_id=info:pmid/33891645&rft_galeid=A659472751&rft_doaj_id=oai_doaj_org_article_e4e7e676b7f64b4e89d4c687db79a060&rfr_iscdi=true |