Vertical transmission of chikungunya virus: A systematic review
To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed...
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| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0249166-e0249166 |
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| creator | Ferreira, Fátima Cristiane Pinho de Almeida Di Maio da Silva, Anamaria Szrajbman Vaz Recht, Judith Guaraldo, Lusiele Moreira, Maria Elisabeth Lopes de Siqueira, André Machado Gerardin, Patrick Brasil, Patrícia |
| description | To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate.
We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded.
From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life.
We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants. |
| doi_str_mv | 10.1371/journal.pone.0249166 |
| format | Article |
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We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded.
From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life.
We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0249166</identifier><identifier>PMID: 33891622</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amniotic fluid ; Biology and life sciences ; Chikungunya virus ; Cytomegalovirus ; Data analysis ; Diagnosis ; Distribution ; Editing ; Electronic mail ; Encephalitis ; Enteroviruses ; Fetuses ; Genetic aspects ; Genomes ; Genotypes ; Herpes simplex ; HIV ; Human immunodeficiency virus ; Illnesses ; Infections ; Laboratories ; Listeria ; Listeria monocytogenes ; Medicine and Health Sciences ; Mosquitoes ; Newborn babies ; Parvoviruses ; Physiological aspects ; Placenta ; Polymerase chain reaction ; Pregnancy ; Research and Analysis Methods ; Reviews ; Sepsis ; Systematic review ; Toxoplasmosis ; Tuberculosis ; Varicella ; Vector-borne diseases ; Vectors ; Viruses ; Visualization</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0249166-e0249166</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Ferreira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Ferreira et al 2021 Ferreira et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d60e999ab919820fb2bb509dca5c3211fcc813af10404e361a5006749af888493</citedby><cites>FETCH-LOGICAL-c692t-d60e999ab919820fb2bb509dca5c3211fcc813af10404e361a5006749af888493</cites><orcidid>0000-0002-2540-8665 ; 0000-0002-3276-5919</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064608/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064608/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33891622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fujioka, Kazumichi</contributor><creatorcontrib>Ferreira, Fátima Cristiane Pinho de Almeida Di Maio</creatorcontrib><creatorcontrib>da Silva, Anamaria Szrajbman Vaz</creatorcontrib><creatorcontrib>Recht, Judith</creatorcontrib><creatorcontrib>Guaraldo, Lusiele</creatorcontrib><creatorcontrib>Moreira, Maria Elisabeth Lopes</creatorcontrib><creatorcontrib>de Siqueira, André Machado</creatorcontrib><creatorcontrib>Gerardin, Patrick</creatorcontrib><creatorcontrib>Brasil, Patrícia</creatorcontrib><title>Vertical transmission of chikungunya virus: A systematic review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate.
We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded.
From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life.
We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. 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babies</subject><subject>Parvoviruses</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Polymerase chain reaction</subject><subject>Pregnancy</subject><subject>Research and Analysis Methods</subject><subject>Reviews</subject><subject>Sepsis</subject><subject>Systematic review</subject><subject>Toxoplasmosis</subject><subject>Tuberculosis</subject><subject>Varicella</subject><subject>Vector-borne 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transmission of chikungunya virus: A systematic review</title><author>Ferreira, Fátima Cristiane Pinho de Almeida Di Maio ; da Silva, Anamaria Szrajbman Vaz ; Recht, Judith ; Guaraldo, Lusiele ; Moreira, Maria Elisabeth Lopes ; de Siqueira, André Machado ; Gerardin, Patrick ; Brasil, Patrícia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d60e999ab919820fb2bb509dca5c3211fcc813af10404e361a5006749af888493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amniotic fluid</topic><topic>Biology and life sciences</topic><topic>Chikungunya virus</topic><topic>Cytomegalovirus</topic><topic>Data analysis</topic><topic>Diagnosis</topic><topic>Distribution</topic><topic>Editing</topic><topic>Electronic mail</topic><topic>Encephalitis</topic><topic>Enteroviruses</topic><topic>Fetuses</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Herpes 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Di Maio</au><au>da Silva, Anamaria Szrajbman Vaz</au><au>Recht, Judith</au><au>Guaraldo, Lusiele</au><au>Moreira, Maria Elisabeth Lopes</au><au>de Siqueira, André Machado</au><au>Gerardin, Patrick</au><au>Brasil, Patrícia</au><au>Fujioka, Kazumichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vertical transmission of chikungunya virus: A systematic review</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-04-23</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0249166</spage><epage>e0249166</epage><pages>e0249166-e0249166</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate.
We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded.
From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life.
We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33891622</pmid><doi>10.1371/journal.pone.0249166</doi><tpages>e0249166</tpages><orcidid>https://orcid.org/0000-0002-2540-8665</orcidid><orcidid>https://orcid.org/0000-0002-3276-5919</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2021-04, Vol.16 (4), p.e0249166-e0249166 |
| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amniotic fluid Biology and life sciences Chikungunya virus Cytomegalovirus Data analysis Diagnosis Distribution Editing Electronic mail Encephalitis Enteroviruses Fetuses Genetic aspects Genomes Genotypes Herpes simplex HIV Human immunodeficiency virus Illnesses Infections Laboratories Listeria Listeria monocytogenes Medicine and Health Sciences Mosquitoes Newborn babies Parvoviruses Physiological aspects Placenta Polymerase chain reaction Pregnancy Research and Analysis Methods Reviews Sepsis Systematic review Toxoplasmosis Tuberculosis Varicella Vector-borne diseases Vectors Viruses Visualization |
| title | Vertical transmission of chikungunya virus: A systematic review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T09%3A13%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vertical%20transmission%20of%20chikungunya%20virus:%20A%20systematic%20review&rft.jtitle=PloS%20one&rft.au=Ferreira,%20F%C3%A1tima%20Cristiane%20Pinho%20de%20Almeida%20Di%20Maio&rft.date=2021-04-23&rft.volume=16&rft.issue=4&rft.spage=e0249166&rft.epage=e0249166&rft.pages=e0249166-e0249166&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0249166&rft_dat=%3Cgale_plos_%3EA659472762%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2517336633&rft_id=info:pmid/33891622&rft_galeid=A659472762&rft_doaj_id=oai_doaj_org_article_824b18ab03b54dd285e94cab48fbc586&rfr_iscdi=true |