Constitutive G protein coupling profiles of understudied orphan GPCRs

A large number of GPCRs are potentially valuable drug targets but remain understudied. Many of these lack well-validated activating ligands and are considered "orphan" receptors, and G protein coupling profiles have not been defined for many orphan GPCRs. Here we asked if constitutive rece...

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Veröffentlicht in:	PloS one 2021-04, Vol.16 (4), p.e0247743
Hauptverfasser:	Lu, Sumin, Jang, Wonjo, Inoue, Asuka, Lambert, Nevin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Calcium Coupling Cyclic AMP Data points Drug delivery Drugs Editing Experiments Funding G protein-coupled receptors G proteins Genetic aspects Graduate schools Graduate studies Hypothesis testing Ligands Medical research Pharmacology Physiological aspects Plasmids Protein families Proteins Research and Analysis Methods Reviews Statistical analysis Statistical analysis of data Toxicology
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