Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio
The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before. This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals. Retrospective, observational c...
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| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0250400-e0250400 |
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| creator | Khan, Muhammad Shayan Dogra, Ratika Miriyala, Leela K V Salman, F N U Ishtiaq, Rizwan Patti, Dilnoor K Kumar, Aakash Sandho, Gaurav Jacob, Karim Luthra, Kritika Sharma, Ravina Ravikumar, Rekha Edara, Dharmakaruna Pittampalli, Shanti Sood, Divya Khatri, Vinod Mahajan, Vijay Avasthi, Salil Auoad, Arlette Katragadda, Srinivas |
| description | The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before.
This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals.
Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne's hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient.
470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1-63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18-29); Hypertension [OR 3.6 (95% CI 1.6-7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7-5.6, p |
| doi_str_mv | 10.1371/journal.pone.0250400 |
| format | Article |
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This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals.
Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne's hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient.
470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1-63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18-29); Hypertension [OR 3.6 (95% CI 1.6-7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7-5.6, p<0.001)]; COPD [OR 3.4 (95% CI 1.8-6.3, p<0.001)] and CKD stage 2 or greater [OR 2.5 (95% CI 1.3-4.9, p = 0.006)]. Combining all age groups, subjects with hypertension had significantly greater odds of the following adverse outcomes: requiring hospital admission (OR 2.2, 95% CI 1.4-3.4, p<0.001); needing respiratory support in 24 hours (OR 2.5, 95% CI: 1.7-3.7, p<0.001); ICU admission (OR 2.7, 95% CI 1.7-4.4, p<0.001); and death (OR 3.6, 95% CI 1.6-7.8, p = 0.001). Hypertension was not associated with needing vent in 24 hours (p = 0.07).
Age and hypertension were associated with significant comorbidity and mortality in Covid-19 Positive patients. Furthermore, people who were older than 70, and had hypertension, diabetes, COPD, or CKD had higher odds of dying from the disease as compared to patients who hadn't. Subjects with hypertension also had significantly greater odds of other adverse outcomes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0250400</identifier><identifier>PMID: 33886663</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Age groups ; Aged ; Biology and Life Sciences ; Comorbidity ; Complications and side effects ; Corona ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 - mortality ; COVID-19 - therapy ; Critical care ; Data analysis ; Demographic aspects ; Diabetes ; Diabetes Mellitus - epidemiology ; Disease ; Drafting software ; Editing ; Epidemics ; Epidemiology ; Female ; Global health ; Health care facilities ; Hospital Mortality ; Hospitals ; Humans ; Hypertension ; Hypertension - epidemiology ; Infectious diseases ; Intensive Care Units ; Internal medicine ; Male ; Medicine ; Medicine and Health Sciences ; Methodology ; Middle Aged ; Middle East respiratory syndrome ; Morbidity ; Mortality ; Ohio - epidemiology ; Pandemics ; Patient outcomes ; Patients ; People and Places ; Physiological aspects ; Public health ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Renal Insufficiency, Chronic - epidemiology ; Respiratory diseases ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 - isolation & purification ; Severe acute respiratory syndrome coronavirus 2 ; United States ; Viral diseases ; Viruses ; Visualization ; Young Adult</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0250400-e0250400</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Khan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Khan et al 2021 Khan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-e9395886f09265126e19c4419ea5147225d1c05a49029b1df9b0b8f35fdabb663</citedby><cites>FETCH-LOGICAL-c593t-e9395886f09265126e19c4419ea5147225d1c05a49029b1df9b0b8f35fdabb663</cites><orcidid>0000-0002-4609-6656 ; 0000-0002-2888-1191</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061926/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061926/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33886663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ahmad, Rasheed</contributor><creatorcontrib>Khan, Muhammad Shayan</creatorcontrib><creatorcontrib>Dogra, Ratika</creatorcontrib><creatorcontrib>Miriyala, Leela K V</creatorcontrib><creatorcontrib>Salman, F N U</creatorcontrib><creatorcontrib>Ishtiaq, Rizwan</creatorcontrib><creatorcontrib>Patti, Dilnoor K</creatorcontrib><creatorcontrib>Kumar, Aakash</creatorcontrib><creatorcontrib>Sandho, Gaurav</creatorcontrib><creatorcontrib>Jacob, Karim</creatorcontrib><creatorcontrib>Luthra, Kritika</creatorcontrib><creatorcontrib>Sharma, Ravina</creatorcontrib><creatorcontrib>Ravikumar, Rekha</creatorcontrib><creatorcontrib>Edara, Dharmakaruna</creatorcontrib><creatorcontrib>Pittampalli, Shanti</creatorcontrib><creatorcontrib>Sood, Divya</creatorcontrib><creatorcontrib>Khatri, Vinod</creatorcontrib><creatorcontrib>Mahajan, Vijay</creatorcontrib><creatorcontrib>Avasthi, Salil</creatorcontrib><creatorcontrib>Auoad, Arlette</creatorcontrib><creatorcontrib>Katragadda, Srinivas</creatorcontrib><title>Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before.
This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals.
Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne's hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient.
470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1-63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18-29); Hypertension [OR 3.6 (95% CI 1.6-7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7-5.6, p<0.001)]; COPD [OR 3.4 (95% CI 1.8-6.3, p<0.001)] and CKD stage 2 or greater [OR 2.5 (95% CI 1.3-4.9, p = 0.006)]. Combining all age groups, subjects with hypertension had significantly greater odds of the following adverse outcomes: requiring hospital admission (OR 2.2, 95% CI 1.4-3.4, p<0.001); needing respiratory support in 24 hours (OR 2.5, 95% CI: 1.7-3.7, p<0.001); ICU admission (OR 2.7, 95% CI 1.7-4.4, p<0.001); and death (OR 3.6, 95% CI 1.6-7.8, p = 0.001). Hypertension was not associated with needing vent in 24 hours (p = 0.07).
Age and hypertension were associated with significant comorbidity and mortality in Covid-19 Positive patients. Furthermore, people who were older than 70, and had hypertension, diabetes, COPD, or CKD had higher odds of dying from the disease as compared to patients who hadn't. Subjects with hypertension also had significantly greater odds of other adverse outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Age groups</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Corona</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - therapy</subject><subject>Critical care</subject><subject>Data analysis</subject><subject>Demographic aspects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Disease</subject><subject>Drafting software</subject><subject>Editing</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Global health</subject><subject>Health care facilities</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Infectious diseases</subject><subject>Intensive Care Units</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Middle Aged</subject><subject>Middle East respiratory syndrome</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Ohio - epidemiology</subject><subject>Pandemics</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>People and Places</subject><subject>Physiological aspects</subject><subject>Public health</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Respiratory diseases</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>United States</subject><subject>Viral diseases</subject><subject>Viruses</subject><subject>Visualization</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEUXCEQ_YB_gMASlyI1wd9ZX5CqFEikolxKr5bX600cOevU3gX13D_OS7OtGlT5YOt5Zt6bpymKDwSPCZuQr-vYp9aE8Ta2boypwBzjV8UxUYyOJMXs9bP3UXGS8xpjwUop3xZHjJXwkOy4uJ8G33prArIrk4ztXPK58zYj09Yo9p2NG5dRbNDWdN61XUZ_fbdC05hia9CNT31Glz47kx2imCh0Nl3czC9HRH1BpkO_XLJ3aOZMANIs5q3vTMjn6DoGV8dztFj5-K5400DRvR_u0-L3j-_X09noavFzPr24GlmhWDdyiikBczdYUSkIlY4oyzlRzgjCJ5SKmlgsDFeYqorUjapwVTZMNLWpKnB7Wnza625DzHrYX9ZUEFmCosKAmO8RdTRrvU1-Y9Kdjsbrh0JMS20SbCc4TRm3Tjaccco5Zq6qKj4piZKyruuJrEDr29CtrzautrC7ZMKB6OFP61d6Gf_oEksCDkHgbBBI8bZ3udMbn60LwbQu9g9zl5RSXgqAfv4P-rK7AbU0YMC3TYS-dieqLwAAThQmgBq_gIJTu423ELbGQ_2AwPcEm2LOyTVPHgnWu6g-DqN3UdVDVIH28fl-nkiP2WT_AGVb454</recordid><startdate>20210422</startdate><enddate>20210422</enddate><creator>Khan, 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characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio</title><author>Khan, Muhammad Shayan ; Dogra, Ratika ; Miriyala, Leela K V ; Salman, F N U ; Ishtiaq, Rizwan ; Patti, Dilnoor K ; Kumar, Aakash ; Sandho, Gaurav ; Jacob, Karim ; Luthra, Kritika ; Sharma, Ravina ; Ravikumar, Rekha ; Edara, Dharmakaruna ; Pittampalli, Shanti ; Sood, Divya ; Khatri, Vinod ; Mahajan, Vijay ; Avasthi, Salil ; Auoad, Arlette ; Katragadda, Srinivas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-e9395886f09265126e19c4419ea5147225d1c05a49029b1df9b0b8f35fdabb663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Age groups</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Comorbidity</topic><topic>Complications 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Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Muhammad Shayan</au><au>Dogra, Ratika</au><au>Miriyala, Leela K V</au><au>Salman, F N U</au><au>Ishtiaq, Rizwan</au><au>Patti, Dilnoor K</au><au>Kumar, Aakash</au><au>Sandho, Gaurav</au><au>Jacob, Karim</au><au>Luthra, Kritika</au><au>Sharma, Ravina</au><au>Ravikumar, Rekha</au><au>Edara, Dharmakaruna</au><au>Pittampalli, Shanti</au><au>Sood, Divya</au><au>Khatri, Vinod</au><au>Mahajan, Vijay</au><au>Avasthi, Salil</au><au>Auoad, Arlette</au><au>Katragadda, Srinivas</au><au>Ahmad, Rasheed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-04-22</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0250400</spage><epage>e0250400</epage><pages>e0250400-e0250400</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before.
This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals.
Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne's hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient.
470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1-63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18-29); Hypertension [OR 3.6 (95% CI 1.6-7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7-5.6, p<0.001)]; COPD [OR 3.4 (95% CI 1.8-6.3, p<0.001)] and CKD stage 2 or greater [OR 2.5 (95% CI 1.3-4.9, p = 0.006)]. Combining all age groups, subjects with hypertension had significantly greater odds of the following adverse outcomes: requiring hospital admission (OR 2.2, 95% CI 1.4-3.4, p<0.001); needing respiratory support in 24 hours (OR 2.5, 95% CI: 1.7-3.7, p<0.001); ICU admission (OR 2.7, 95% CI 1.7-4.4, p<0.001); and death (OR 3.6, 95% CI 1.6-7.8, p = 0.001). Hypertension was not associated with needing vent in 24 hours (p = 0.07).
Age and hypertension were associated with significant comorbidity and mortality in Covid-19 Positive patients. Furthermore, people who were older than 70, and had hypertension, diabetes, COPD, or CKD had higher odds of dying from the disease as compared to patients who hadn't. Subjects with hypertension also had significantly greater odds of other adverse outcomes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33886663</pmid><doi>10.1371/journal.pone.0250400</doi><orcidid>https://orcid.org/0000-0002-4609-6656</orcidid><orcidid>https://orcid.org/0000-0002-2888-1191</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-04, Vol.16 (4), p.e0250400-e0250400 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2516826590 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Age Factors Age groups Aged Biology and Life Sciences Comorbidity Complications and side effects Corona Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - mortality COVID-19 - therapy Critical care Data analysis Demographic aspects Diabetes Diabetes Mellitus - epidemiology Disease Drafting software Editing Epidemics Epidemiology Female Global health Health care facilities Hospital Mortality Hospitals Humans Hypertension Hypertension - epidemiology Infectious diseases Intensive Care Units Internal medicine Male Medicine Medicine and Health Sciences Methodology Middle Aged Middle East respiratory syndrome Morbidity Mortality Ohio - epidemiology Pandemics Patient outcomes Patients People and Places Physiological aspects Public health Pulmonary Disease, Chronic Obstructive - epidemiology Renal Insufficiency, Chronic - epidemiology Respiratory diseases Retrospective Studies Risk Factors SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 United States Viral diseases Viruses Visualization Young Adult |
| title | Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio |
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