ELISA detection of MPO-DNA complexes in human plasma is error-prone and yields limited information on neutrophil extracellular traps formed in vivo

Over the past years, neutrophil extracellular traps (NETs) were shown to contribute to states of acute and chronic inflammatory disease. They are composed of expelled chromatin and decorated by neutrophil-derived proteins. Therefore, the analysis of DNA complexes with myeloperoxidase (MPO) by ELISA...

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Veröffentlicht in:	PloS one 2021-04, Vol.16 (4), p.e0250265-e0250265
Hauptverfasser:	Hayden, Hubert, Ibrahim, Nahla, Klopf, Johannes, Zagrapan, Branislav, Mauracher, Lisa-Marie, Hell, Lena, Hofbauer, Thomas M, Ondracek, Anna S, Schoergenhofer, Christian, Jilma, Bernd, Lang, Irene M, Pabinger, Ingrid, Eilenberg, Wolf, Neumayer, Christoph, Brostjan, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biology and Life Sciences Biomarkers Blood Blood plasma Cardiology Citrulline Deoxyribonucleic acid DNA Engineering and Technology Enzyme-linked immunosorbent assay Genetic aspects Hematology Histones Hospitals Internal medicine Leukocytes (neutrophilic) Medicine Medicine and Health Sciences Neutrophils Parameters Physical Sciences Physiological aspects Plasma Protein-arginine deiminase Proteins Protocol Research and Analysis Methods Vascular surgery
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