Cornea donation process and tissue quality for transplantation
The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it i...
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| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0249927-e0249927 |
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| creator | Pereira Cruz, Giovanna Karinny Ferreira Júnior, Marcos Antonio Pereira Frota, Oleci Ferraz Teston, Elen Pereira Santos, Viviane Euzébia Fortes Vitor, Allyne Penza Cardoso, Mayk Rodrigues Leocates de Moraes, Fábio Rogério |
| description | The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp.
To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation.
This is an epidemiologic study, retrospective cohort type, which addressed the process of cornea donation by the Human Eye Tissue Bank in a reference service in Northeast Brazil. The sample consisted of corneas processed by the Human Eye Tissue Bank of Rio Grande do Norte (n = 419). For descriptive and inferential analysis, the study used the Statistical Package for the Social Sciences (SPSS) software, version 25.0, and considered a significance level of 0.05. Logistic regression analysis was used for the adjustment of the final model.
It was verified that the epidemiological profile showed a prevalence of individuals with a mean age of 42.54 years old, male (73.99%), and living in the metropolitan region of the state capital (75.66%). When analyzing the relationship between the clinical and sociodemographic variables of the donors, it was identified that those aged 45 years old or less had better quality corneas (excellent and good), while the chronological variables were predictive factors for corneas of regular and bad qualities.
The identification of the factors inherent to the donation process and predictors of corneal tissue quality contribute to minimizing the risk of transplantation and to a better ocular prognosis. |
| doi_str_mv | 10.1371/journal.pone.0249927 |
| format | Article |
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To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation.
This is an epidemiologic study, retrospective cohort type, which addressed the process of cornea donation by the Human Eye Tissue Bank in a reference service in Northeast Brazil. The sample consisted of corneas processed by the Human Eye Tissue Bank of Rio Grande do Norte (n = 419). For descriptive and inferential analysis, the study used the Statistical Package for the Social Sciences (SPSS) software, version 25.0, and considered a significance level of 0.05. Logistic regression analysis was used for the adjustment of the final model.
It was verified that the epidemiological profile showed a prevalence of individuals with a mean age of 42.54 years old, male (73.99%), and living in the metropolitan region of the state capital (75.66%). When analyzing the relationship between the clinical and sociodemographic variables of the donors, it was identified that those aged 45 years old or less had better quality corneas (excellent and good), while the chronological variables were predictive factors for corneas of regular and bad qualities.
The identification of the factors inherent to the donation process and predictors of corneal tissue quality contribute to minimizing the risk of transplantation and to a better ocular prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0249927</identifier><identifier>PMID: 33878135</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Biology and Life Sciences ; Classification ; Cornea ; Corneal transplantation ; Data collection ; Donation of organs, tissues, etc ; Donations ; Edema ; Editing ; Endothelial cells ; Engineering and Technology ; Ethics ; Eye banks ; Health risks ; Medical personnel ; Medical records ; Medicine and Health Sciences ; Methodology ; Methods ; Nursing ; Opacity ; People and places ; Physical Sciences ; Professional ethics ; Quality control ; Quality management ; Research and Analysis Methods ; Research ethics ; Scars ; Senile ; Statistics ; Supervision ; Technical education ; Transplantation ; Transplants & implants ; Variables ; Visualization</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0249927-e0249927</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Pereira Cruz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Pereira Cruz et al 2021 Pereira Cruz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c762t-d0416228c599c9a0e5035601fdb3a6400097fc7d9eafdc7922f65c867ba1d8203</citedby><cites>FETCH-LOGICAL-c762t-d0416228c599c9a0e5035601fdb3a6400097fc7d9eafdc7922f65c867ba1d8203</cites><orcidid>0000-0002-1242-7840</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057599/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057599/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33878135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira Cruz, Giovanna Karinny</creatorcontrib><creatorcontrib>Ferreira Júnior, Marcos Antonio</creatorcontrib><creatorcontrib>Pereira Frota, Oleci</creatorcontrib><creatorcontrib>Ferraz Teston, Elen</creatorcontrib><creatorcontrib>Pereira Santos, Viviane Euzébia</creatorcontrib><creatorcontrib>Fortes Vitor, Allyne</creatorcontrib><creatorcontrib>Penza Cardoso, Mayk</creatorcontrib><creatorcontrib>Rodrigues Leocates de Moraes, Fábio Rogério</creatorcontrib><title>Cornea donation process and tissue quality for transplantation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp.
To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation.
This is an epidemiologic study, retrospective cohort type, which addressed the process of cornea donation by the Human Eye Tissue Bank in a reference service in Northeast Brazil. The sample consisted of corneas processed by the Human Eye Tissue Bank of Rio Grande do Norte (n = 419). For descriptive and inferential analysis, the study used the Statistical Package for the Social Sciences (SPSS) software, version 25.0, and considered a significance level of 0.05. Logistic regression analysis was used for the adjustment of the final model.
It was verified that the epidemiological profile showed a prevalence of individuals with a mean age of 42.54 years old, male (73.99%), and living in the metropolitan region of the state capital (75.66%). When analyzing the relationship between the clinical and sociodemographic variables of the donors, it was identified that those aged 45 years old or less had better quality corneas (excellent and good), while the chronological variables were predictive factors for corneas of regular and bad qualities.
The identification of the factors inherent to the donation process and predictors of corneal tissue quality contribute to minimizing the risk of transplantation and to a better ocular prognosis.</description><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Classification</subject><subject>Cornea</subject><subject>Corneal transplantation</subject><subject>Data collection</subject><subject>Donation of organs, tissues, etc</subject><subject>Donations</subject><subject>Edema</subject><subject>Editing</subject><subject>Endothelial cells</subject><subject>Engineering and Technology</subject><subject>Ethics</subject><subject>Eye banks</subject><subject>Health risks</subject><subject>Medical personnel</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Methods</subject><subject>Nursing</subject><subject>Opacity</subject><subject>People and places</subject><subject>Physical 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donation process and tissue quality for transplantation</title><author>Pereira Cruz, Giovanna Karinny ; Ferreira Júnior, Marcos Antonio ; Pereira Frota, Oleci ; Ferraz Teston, Elen ; Pereira Santos, Viviane Euzébia ; Fortes Vitor, Allyne ; Penza Cardoso, Mayk ; Rodrigues Leocates de Moraes, Fábio Rogério</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c762t-d0416228c599c9a0e5035601fdb3a6400097fc7d9eafdc7922f65c867ba1d8203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Classification</topic><topic>Cornea</topic><topic>Corneal transplantation</topic><topic>Data collection</topic><topic>Donation of organs, tissues, etc</topic><topic>Donations</topic><topic>Edema</topic><topic>Editing</topic><topic>Endothelial cells</topic><topic>Engineering and Technology</topic><topic>Ethics</topic><topic>Eye 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Oleci</au><au>Ferraz Teston, Elen</au><au>Pereira Santos, Viviane Euzébia</au><au>Fortes Vitor, Allyne</au><au>Penza Cardoso, Mayk</au><au>Rodrigues Leocates de Moraes, Fábio Rogério</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cornea donation process and tissue quality for transplantation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-04-20</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0249927</spage><epage>e0249927</epage><pages>e0249927-e0249927</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp.
To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation.
This is an epidemiologic study, retrospective cohort type, which addressed the process of cornea donation by the Human Eye Tissue Bank in a reference service in Northeast Brazil. The sample consisted of corneas processed by the Human Eye Tissue Bank of Rio Grande do Norte (n = 419). For descriptive and inferential analysis, the study used the Statistical Package for the Social Sciences (SPSS) software, version 25.0, and considered a significance level of 0.05. Logistic regression analysis was used for the adjustment of the final model.
It was verified that the epidemiological profile showed a prevalence of individuals with a mean age of 42.54 years old, male (73.99%), and living in the metropolitan region of the state capital (75.66%). When analyzing the relationship between the clinical and sociodemographic variables of the donors, it was identified that those aged 45 years old or less had better quality corneas (excellent and good), while the chronological variables were predictive factors for corneas of regular and bad qualities.
The identification of the factors inherent to the donation process and predictors of corneal tissue quality contribute to minimizing the risk of transplantation and to a better ocular prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33878135</pmid><doi>10.1371/journal.pone.0249927</doi><tpages>e0249927</tpages><orcidid>https://orcid.org/0000-0002-1242-7840</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Biology and Life Sciences Classification Cornea Corneal transplantation Data collection Donation of organs, tissues, etc Donations Edema Editing Endothelial cells Engineering and Technology Ethics Eye banks Health risks Medical personnel Medical records Medicine and Health Sciences Methodology Methods Nursing Opacity People and places Physical Sciences Professional ethics Quality control Quality management Research and Analysis Methods Research ethics Scars Senile Statistics Supervision Technical education Transplantation Transplants & implants Variables Visualization |
| title | Cornea donation process and tissue quality for transplantation |
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