Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis

There is a continued need to develop effective and safe treatments for visceral leishmaniasis (VL). Preclinical studies on pharmacokinetics and pharmacodynamics of anti-infective agents, such as anti-bacterials and anti-fungals, have provided valuable information in the development and dosing of the...

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Veröffentlicht in:	PLoS neglected tropical diseases 2021-03, Vol.15 (3), p.e0009013
Hauptverfasser:	Voak, Andrew A, Harris, Andy, Coteron-Lopez, Jose Miguel, Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Croft, Simon L, Seifert, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Amphotericin B Animal welfare Animals Antifungal agents Biology and Life Sciences Calibration Chemical properties Dosage and administration Drug dosages Drug therapy Ethics Experiments Formic acid Gaussian distribution High performance liquid chromatography HPLC Infections Kala-azar Liquid chromatography Mass spectrometry Mass spectroscopy Medicine and Health Sciences Miltefosine Normal distribution Parasites Parasitic diseases Pharmacodynamics Pharmacokinetics Pharmacology Pharmacology, Experimental Physiological aspects Plasma Quality control Samples Statistical analysis Statistical methods Statistics Tolbutamide Tropical diseases Variance analysis Vector-borne diseases Visceral leishmaniasis
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