A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?
Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic rev...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2021-03, Vol.15 (3), p.e0009144 |
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| creator | Jittamala, Podjanee Monteiro, Wuelton Smit, Menno R Pedrique, Belen Specht, Sabine Chaccour, Carlos J Dard, Céline Del Giudice, Pascal Khieu, Virak Maruani, Annabel Failoc-Rojas, Virgilio E Sáez-de-Ocariz, Marimar Soriano-Arandes, Antoni Piquero-Casals, Jaime Faisant, Anne Brenier-Pinchart, Marie-Pierre Wimmersberger, David Coulibaly, Jean T Keiser, Jennifer Boralevi, Franck Sokana, Oliver Marks, Michael Engelman, Daniel Romani, Lucia Steer, Andrew C von Seidlein, Lorenz White, Nicholas J Harriss, Eli Stepniewska, Kasia Humphreys, Georgina S Kennon, Kalynn Guerin, Philippe J Kobylinski, Kevin C |
| description | Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg.
A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported.
Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance. |
| doi_str_mv | 10.1371/journal.pntd.0009144 |
| format | Article |
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A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported.
Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0009144</identifier><identifier>PMID: 33730099</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Administration, Oral ; Anthelmintics - administration & dosage ; Anthelmintics - adverse effects ; Body Weight ; Boys ; Case reports ; Child, Preschool ; Children ; Children & youth ; Communicable diseases in children ; Contraindications ; Drug development ; Drug dosages ; Drug therapy ; Drugs ; Girls ; Health aspects ; Helminthiasis - drug therapy ; Humans ; Infant ; Ivermectin ; Ivermectin - administration & dosage ; Ivermectin - adverse effects ; Life Sciences ; Lindane ; Medicine and Health Sciences ; Meta-analysis ; Neglected Diseases - drug therapy ; Onchocerciasis ; Parasitic diseases ; Pediatric research ; People and Places ; Research and Analysis Methods ; Scabies ; Side effects ; Strongyloidiasis ; Systematic review ; Therapeutic drug monitoring ; Thiabendazole ; Tropical diseases ; Weighing ; Weight</subject><ispartof>PLoS neglected tropical diseases, 2021-03, Vol.15 (3), p.e0009144</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Jittamala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2021 Jittamala et al 2021 Jittamala et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-c2022a6460763befb4dfcf478e9625f38c98dc39d4a0021c81155c883bfb37793</citedby><cites>FETCH-LOGICAL-c658t-c2022a6460763befb4dfcf478e9625f38c98dc39d4a0021c81155c883bfb37793</cites><orcidid>0000-0002-4909-1287 ; 0000-0001-9812-050X ; 0000-0002-0282-6469 ; 0000-0001-7557-4197 ; 0000-0003-0290-3521 ; 0000-0002-1897-1978 ; 0000-0001-9613-7228 ; 0000-0003-3531-0298 ; 0000-0002-7585-4743 ; 0000-0002-4807-9681 ; 0000-0001-9038-5300 ; 0000-0002-6008-2963 ; 0000-0003-4635-8959 ; 0000-0002-1020-2760 ; 0000-0003-3405-6638 ; 0000-0003-4726-2983 ; 0000-0003-1366-5856 ; 0000-0003-2992-9342 ; 0000-0001-9947-0034 ; 0000-0003-3734-810X ; 0000-0002-4481-5602 ; 0000-0002-1713-6209 ; 0000-0001-7346-0196 ; 0000-0002-5843-0842 ; 0000-0001-7435-7262 ; 0000-0002-0848-1940</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968658/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968658/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33730099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03407125$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Downs, Jennifer A.</contributor><creatorcontrib>Jittamala, Podjanee</creatorcontrib><creatorcontrib>Monteiro, Wuelton</creatorcontrib><creatorcontrib>Smit, Menno R</creatorcontrib><creatorcontrib>Pedrique, Belen</creatorcontrib><creatorcontrib>Specht, Sabine</creatorcontrib><creatorcontrib>Chaccour, Carlos J</creatorcontrib><creatorcontrib>Dard, Céline</creatorcontrib><creatorcontrib>Del Giudice, Pascal</creatorcontrib><creatorcontrib>Khieu, Virak</creatorcontrib><creatorcontrib>Maruani, Annabel</creatorcontrib><creatorcontrib>Failoc-Rojas, Virgilio E</creatorcontrib><creatorcontrib>Sáez-de-Ocariz, Marimar</creatorcontrib><creatorcontrib>Soriano-Arandes, Antoni</creatorcontrib><creatorcontrib>Piquero-Casals, Jaime</creatorcontrib><creatorcontrib>Faisant, Anne</creatorcontrib><creatorcontrib>Brenier-Pinchart, Marie-Pierre</creatorcontrib><creatorcontrib>Wimmersberger, David</creatorcontrib><creatorcontrib>Coulibaly, Jean T</creatorcontrib><creatorcontrib>Keiser, Jennifer</creatorcontrib><creatorcontrib>Boralevi, Franck</creatorcontrib><creatorcontrib>Sokana, Oliver</creatorcontrib><creatorcontrib>Marks, Michael</creatorcontrib><creatorcontrib>Engelman, Daniel</creatorcontrib><creatorcontrib>Romani, Lucia</creatorcontrib><creatorcontrib>Steer, Andrew C</creatorcontrib><creatorcontrib>von Seidlein, Lorenz</creatorcontrib><creatorcontrib>White, Nicholas J</creatorcontrib><creatorcontrib>Harriss, Eli</creatorcontrib><creatorcontrib>Stepniewska, Kasia</creatorcontrib><creatorcontrib>Humphreys, Georgina S</creatorcontrib><creatorcontrib>Kennon, Kalynn</creatorcontrib><creatorcontrib>Guerin, Philippe J</creatorcontrib><creatorcontrib>Kobylinski, Kevin C</creatorcontrib><title>A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg.
A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported.
Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.</description><subject>Administration, Oral</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - adverse effects</subject><subject>Body Weight</subject><subject>Boys</subject><subject>Case reports</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Communicable diseases in children</subject><subject>Contraindications</subject><subject>Drug development</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Girls</subject><subject>Health aspects</subject><subject>Helminthiasis - drug therapy</subject><subject>Humans</subject><subject>Infant</subject><subject>Ivermectin</subject><subject>Ivermectin - administration & dosage</subject><subject>Ivermectin - adverse effects</subject><subject>Life Sciences</subject><subject>Lindane</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Neglected Diseases - drug therapy</subject><subject>Onchocerciasis</subject><subject>Parasitic diseases</subject><subject>Pediatric research</subject><subject>People and Places</subject><subject>Research and Analysis Methods</subject><subject>Scabies</subject><subject>Side effects</subject><subject>Strongyloidiasis</subject><subject>Systematic review</subject><subject>Therapeutic drug monitoring</subject><subject>Thiabendazole</subject><subject>Tropical 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systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?</title><author>Jittamala, Podjanee ; Monteiro, Wuelton ; Smit, Menno R ; Pedrique, Belen ; Specht, Sabine ; Chaccour, Carlos J ; Dard, Céline ; Del Giudice, Pascal ; Khieu, Virak ; Maruani, Annabel ; Failoc-Rojas, Virgilio E ; Sáez-de-Ocariz, Marimar ; Soriano-Arandes, Antoni ; Piquero-Casals, Jaime ; Faisant, Anne ; Brenier-Pinchart, Marie-Pierre ; Wimmersberger, David ; Coulibaly, Jean T ; Keiser, Jennifer ; Boralevi, Franck ; Sokana, Oliver ; Marks, Michael ; Engelman, Daniel ; Romani, Lucia ; Steer, Andrew C ; von Seidlein, Lorenz ; White, Nicholas J ; Harriss, Eli ; Stepniewska, Kasia ; Humphreys, Georgina S ; Kennon, Kalynn ; Guerin, Philippe J ; Kobylinski, Kevin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c658t-c2022a6460763befb4dfcf478e9625f38c98dc39d4a0021c81155c883bfb37793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Administration, Oral</topic><topic>Anthelmintics - administration & dosage</topic><topic>Anthelmintics - adverse effects</topic><topic>Body Weight</topic><topic>Boys</topic><topic>Case reports</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Communicable diseases in children</topic><topic>Contraindications</topic><topic>Drug development</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>Girls</topic><topic>Health aspects</topic><topic>Helminthiasis - drug therapy</topic><topic>Humans</topic><topic>Infant</topic><topic>Ivermectin</topic><topic>Ivermectin - administration & dosage</topic><topic>Ivermectin - adverse effects</topic><topic>Life Sciences</topic><topic>Lindane</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Neglected Diseases - drug therapy</topic><topic>Onchocerciasis</topic><topic>Parasitic diseases</topic><topic>Pediatric research</topic><topic>People and Places</topic><topic>Research and Analysis Methods</topic><topic>Scabies</topic><topic>Side effects</topic><topic>Strongyloidiasis</topic><topic>Systematic review</topic><topic>Therapeutic drug monitoring</topic><topic>Thiabendazole</topic><topic>Tropical diseases</topic><topic>Weighing</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jittamala, Podjanee</creatorcontrib><creatorcontrib>Monteiro, Wuelton</creatorcontrib><creatorcontrib>Smit, Menno R</creatorcontrib><creatorcontrib>Pedrique, Belen</creatorcontrib><creatorcontrib>Specht, Sabine</creatorcontrib><creatorcontrib>Chaccour, Carlos J</creatorcontrib><creatorcontrib>Dard, Céline</creatorcontrib><creatorcontrib>Del Giudice, Pascal</creatorcontrib><creatorcontrib>Khieu, Virak</creatorcontrib><creatorcontrib>Maruani, Annabel</creatorcontrib><creatorcontrib>Failoc-Rojas, Virgilio E</creatorcontrib><creatorcontrib>Sáez-de-Ocariz, Marimar</creatorcontrib><creatorcontrib>Soriano-Arandes, Antoni</creatorcontrib><creatorcontrib>Piquero-Casals, Jaime</creatorcontrib><creatorcontrib>Faisant, Anne</creatorcontrib><creatorcontrib>Brenier-Pinchart, Marie-Pierre</creatorcontrib><creatorcontrib>Wimmersberger, David</creatorcontrib><creatorcontrib>Coulibaly, Jean T</creatorcontrib><creatorcontrib>Keiser, Jennifer</creatorcontrib><creatorcontrib>Boralevi, Franck</creatorcontrib><creatorcontrib>Sokana, Oliver</creatorcontrib><creatorcontrib>Marks, Michael</creatorcontrib><creatorcontrib>Engelman, Daniel</creatorcontrib><creatorcontrib>Romani, Lucia</creatorcontrib><creatorcontrib>Steer, Andrew C</creatorcontrib><creatorcontrib>von Seidlein, Lorenz</creatorcontrib><creatorcontrib>White, Nicholas J</creatorcontrib><creatorcontrib>Harriss, Eli</creatorcontrib><creatorcontrib>Stepniewska, Kasia</creatorcontrib><creatorcontrib>Humphreys, Georgina S</creatorcontrib><creatorcontrib>Kennon, Kalynn</creatorcontrib><creatorcontrib>Guerin, Philippe J</creatorcontrib><creatorcontrib>Kobylinski, Kevin C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS 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Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jittamala, Podjanee</au><au>Monteiro, Wuelton</au><au>Smit, Menno R</au><au>Pedrique, Belen</au><au>Specht, Sabine</au><au>Chaccour, Carlos J</au><au>Dard, Céline</au><au>Del Giudice, Pascal</au><au>Khieu, Virak</au><au>Maruani, Annabel</au><au>Failoc-Rojas, Virgilio E</au><au>Sáez-de-Ocariz, Marimar</au><au>Soriano-Arandes, Antoni</au><au>Piquero-Casals, Jaime</au><au>Faisant, Anne</au><au>Brenier-Pinchart, Marie-Pierre</au><au>Wimmersberger, David</au><au>Coulibaly, Jean T</au><au>Keiser, Jennifer</au><au>Boralevi, Franck</au><au>Sokana, Oliver</au><au>Marks, Michael</au><au>Engelman, Daniel</au><au>Romani, Lucia</au><au>Steer, Andrew C</au><au>von Seidlein, Lorenz</au><au>White, Nicholas J</au><au>Harriss, Eli</au><au>Stepniewska, Kasia</au><au>Humphreys, Georgina S</au><au>Kennon, Kalynn</au><au>Guerin, Philippe J</au><au>Kobylinski, Kevin C</au><au>Downs, Jennifer A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>15</volume><issue>3</issue><spage>e0009144</spage><pages>e0009144-</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg.
A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported.
Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33730099</pmid><doi>10.1371/journal.pntd.0009144</doi><orcidid>https://orcid.org/0000-0002-4909-1287</orcidid><orcidid>https://orcid.org/0000-0001-9812-050X</orcidid><orcidid>https://orcid.org/0000-0002-0282-6469</orcidid><orcidid>https://orcid.org/0000-0001-7557-4197</orcidid><orcidid>https://orcid.org/0000-0003-0290-3521</orcidid><orcidid>https://orcid.org/0000-0002-1897-1978</orcidid><orcidid>https://orcid.org/0000-0001-9613-7228</orcidid><orcidid>https://orcid.org/0000-0003-3531-0298</orcidid><orcidid>https://orcid.org/0000-0002-7585-4743</orcidid><orcidid>https://orcid.org/0000-0002-4807-9681</orcidid><orcidid>https://orcid.org/0000-0001-9038-5300</orcidid><orcidid>https://orcid.org/0000-0002-6008-2963</orcidid><orcidid>https://orcid.org/0000-0003-4635-8959</orcidid><orcidid>https://orcid.org/0000-0002-1020-2760</orcidid><orcidid>https://orcid.org/0000-0003-3405-6638</orcidid><orcidid>https://orcid.org/0000-0003-4726-2983</orcidid><orcidid>https://orcid.org/0000-0003-1366-5856</orcidid><orcidid>https://orcid.org/0000-0003-2992-9342</orcidid><orcidid>https://orcid.org/0000-0001-9947-0034</orcidid><orcidid>https://orcid.org/0000-0003-3734-810X</orcidid><orcidid>https://orcid.org/0000-0002-4481-5602</orcidid><orcidid>https://orcid.org/0000-0002-1713-6209</orcidid><orcidid>https://orcid.org/0000-0001-7346-0196</orcidid><orcidid>https://orcid.org/0000-0002-5843-0842</orcidid><orcidid>https://orcid.org/0000-0001-7435-7262</orcidid><orcidid>https://orcid.org/0000-0002-0848-1940</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2021-03, Vol.15 (3), p.e0009144 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2513691081 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Administration, Oral Anthelmintics - administration & dosage Anthelmintics - adverse effects Body Weight Boys Case reports Child, Preschool Children Children & youth Communicable diseases in children Contraindications Drug development Drug dosages Drug therapy Drugs Girls Health aspects Helminthiasis - drug therapy Humans Infant Ivermectin Ivermectin - administration & dosage Ivermectin - adverse effects Life Sciences Lindane Medicine and Health Sciences Meta-analysis Neglected Diseases - drug therapy Onchocerciasis Parasitic diseases Pediatric research People and Places Research and Analysis Methods Scabies Side effects Strongyloidiasis Systematic review Therapeutic drug monitoring Thiabendazole Tropical diseases Weighing Weight |
| title | A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication? |
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