Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participating in an ongoing cohort study of influenza incidence and preva...
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| Veröffentlicht in: | PLoS pathogens 2021-03, Vol.17 (3), p.e1009413 |
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| creator | Gomaa, Mokhtar R El Rifay, Amira S Shehata, Mahmoud Kandeil, Ahmed Nabil Kamel, Mina Marouf, Mohamed A GabAllah, Mohamed El Taweel, Ahmed Kayed, Ahmed E Kutkat, Omnia Moatasim, Yassmin Mahmoud, Sara H Abo Shama, Noura M El Sayes, Mohamed Mostafa, Ahmed El-Shesheny, Rabeh McKenzie, Pamela P Webby, Richard J Kayali, Ghazi Ali, Mohamed A |
| description | SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participating in an ongoing cohort study of influenza incidence and prevalence in rural Egypt were followed. Baseline enrollment was done from August 2015 to March 2017. The study protocol was amended in April 2020 to allow COVID-19 incidence and seroprevalence studies. A total of 290 households including 1598 participants were enrolled and followed from April to October 2020 in four study sites. When a participant showed respiratory illness symptoms, a serum sample and a nasal and an oropharyngeal swab were obtained. Swabs were tested by RT-PCR for SARS-CoV-2 infection. If positive, the subject was followed and swabs collected on days three, six, nine, and 14 after the first swab day and a serum sample obtained on day 14. All subjects residing with the index case were swabbed following the same sampling schedule. Sera were collected from cohort participants in October 2020 to assess seroprevalence. Swabs were tested by RT-PCR. Sera were tested by Microneutralization Assay to measure the neutralizing antibody titer. Incidence of COVID-19, household secondary attack rate, and seroprevalence in the cohort were determined. The incidence of COVID-19 was 6.9% and the household secondary attack rate was 89.8%. Transmission within households occurred within two-days of confirming the index case. Infections were asymptomatic or mild with symptoms resolving within 10 days. The majority developed a neutralizing antibody titer by day 14 post onset. The overall seroprevalence among cohort participants was 34.8%. These results suggest that within-household transmission is high in Egypt. Asymptomatic or mild illness is common. Most infections seroconvert and have a durable neutralizing antibody titer. |
| doi_str_mv | 10.1371/journal.ppat.1009413 |
| format | Article |
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M.</contributor><creatorcontrib>Gomaa, Mokhtar R ; El Rifay, Amira S ; Shehata, Mahmoud ; Kandeil, Ahmed ; Nabil Kamel, Mina ; Marouf, Mohamed A ; GabAllah, Mohamed ; El Taweel, Ahmed ; Kayed, Ahmed E ; Kutkat, Omnia ; Moatasim, Yassmin ; Mahmoud, Sara H ; Abo Shama, Noura M ; El Sayes, Mohamed ; Mostafa, Ahmed ; El-Shesheny, Rabeh ; McKenzie, Pamela P ; Webby, Richard J ; Kayali, Ghazi ; Ali, Mohamed A ; Fouchier, Ron A. M.</creatorcontrib><description>SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participating in an ongoing cohort study of influenza incidence and prevalence in rural Egypt were followed. Baseline enrollment was done from August 2015 to March 2017. The study protocol was amended in April 2020 to allow COVID-19 incidence and seroprevalence studies. A total of 290 households including 1598 participants were enrolled and followed from April to October 2020 in four study sites. When a participant showed respiratory illness symptoms, a serum sample and a nasal and an oropharyngeal swab were obtained. Swabs were tested by RT-PCR for SARS-CoV-2 infection. If positive, the subject was followed and swabs collected on days three, six, nine, and 14 after the first swab day and a serum sample obtained on day 14. All subjects residing with the index case were swabbed following the same sampling schedule. Sera were collected from cohort participants in October 2020 to assess seroprevalence. Swabs were tested by RT-PCR. Sera were tested by Microneutralization Assay to measure the neutralizing antibody titer. Incidence of COVID-19, household secondary attack rate, and seroprevalence in the cohort were determined. The incidence of COVID-19 was 6.9% and the household secondary attack rate was 89.8%. Transmission within households occurred within two-days of confirming the index case. Infections were asymptomatic or mild with symptoms resolving within 10 days. The majority developed a neutralizing antibody titer by day 14 post onset. The overall seroprevalence among cohort participants was 34.8%. These results suggest that within-household transmission is high in Egypt. Asymptomatic or mild illness is common. Most infections seroconvert and have a durable neutralizing antibody titer.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1009413</identifier><identifier>PMID: 33705496</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; Biology and Life Sciences ; Causes of ; Child ; Chronic illnesses ; Cohort Studies ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - transmission ; COVID-19 - virology ; Demographic aspects ; Diabetes mellitus ; Disease transmission ; Egypt - epidemiology ; Family ; Female ; Health aspects ; Health care ; Households ; Human populations ; Humans ; Hypertension ; Incidence ; Infections ; Male ; Medicine and Health Sciences ; Middle Aged ; Pandemics ; People and Places ; Polymerase chain reaction ; Research and Analysis Methods ; Respiratory diseases ; Risk analysis ; Risk factors ; SARS-CoV-2 - genetics ; SARS-CoV-2 - immunology ; SARS-CoV-2 - physiology ; Seroepidemiologic Studies ; Serology ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Viral diseases ; Young Adult</subject><ispartof>PLoS pathogens, 2021-03, Vol.17 (3), p.e1009413</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Gomaa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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M.</contributor><creatorcontrib>Gomaa, Mokhtar R</creatorcontrib><creatorcontrib>El Rifay, Amira S</creatorcontrib><creatorcontrib>Shehata, Mahmoud</creatorcontrib><creatorcontrib>Kandeil, Ahmed</creatorcontrib><creatorcontrib>Nabil Kamel, Mina</creatorcontrib><creatorcontrib>Marouf, Mohamed A</creatorcontrib><creatorcontrib>GabAllah, Mohamed</creatorcontrib><creatorcontrib>El Taweel, Ahmed</creatorcontrib><creatorcontrib>Kayed, Ahmed E</creatorcontrib><creatorcontrib>Kutkat, Omnia</creatorcontrib><creatorcontrib>Moatasim, Yassmin</creatorcontrib><creatorcontrib>Mahmoud, Sara H</creatorcontrib><creatorcontrib>Abo Shama, Noura M</creatorcontrib><creatorcontrib>El Sayes, Mohamed</creatorcontrib><creatorcontrib>Mostafa, Ahmed</creatorcontrib><creatorcontrib>El-Shesheny, Rabeh</creatorcontrib><creatorcontrib>McKenzie, Pamela P</creatorcontrib><creatorcontrib>Webby, Richard J</creatorcontrib><creatorcontrib>Kayali, Ghazi</creatorcontrib><creatorcontrib>Ali, Mohamed A</creatorcontrib><title>Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participating in an ongoing cohort study of influenza incidence and prevalence in rural Egypt were followed. Baseline enrollment was done from August 2015 to March 2017. The study protocol was amended in April 2020 to allow COVID-19 incidence and seroprevalence studies. A total of 290 households including 1598 participants were enrolled and followed from April to October 2020 in four study sites. When a participant showed respiratory illness symptoms, a serum sample and a nasal and an oropharyngeal swab were obtained. Swabs were tested by RT-PCR for SARS-CoV-2 infection. If positive, the subject was followed and swabs collected on days three, six, nine, and 14 after the first swab day and a serum sample obtained on day 14. All subjects residing with the index case were swabbed following the same sampling schedule. Sera were collected from cohort participants in October 2020 to assess seroprevalence. Swabs were tested by RT-PCR. Sera were tested by Microneutralization Assay to measure the neutralizing antibody titer. Incidence of COVID-19, household secondary attack rate, and seroprevalence in the cohort were determined. The incidence of COVID-19 was 6.9% and the household secondary attack rate was 89.8%. Transmission within households occurred within two-days of confirming the index case. Infections were asymptomatic or mild with symptoms resolving within 10 days. The majority developed a neutralizing antibody titer by day 14 post onset. The overall seroprevalence among cohort participants was 34.8%. These results suggest that within-household transmission is high in Egypt. Asymptomatic or mild illness is common. 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genetics</subject><subject>SARS-CoV-2 - immunology</subject><subject>SARS-CoV-2 - physiology</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Viral diseases</subject><subject>Young Adult</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVktGO1CAUhhujcdfVNzBK4pXJzgilLcULk8246iQbTVa9JhROO0w60AU6cXwP31fG6W52Er0wXACH7_-Bc06WPSd4Tigjb9Zu9Fb282GQcU4w5gWhD7JTUpZ0xigrHt5bn2RPQlhjnBBSPc5OKGW4LHh1mv1aWmU0WAXnaOXGACvXaxS9tGFjQjDOniNpNbIwpmBvfhrbpUA0jdM7FMC7wcNW9nsH5Fq0cN5ZuTV-DOi9CSADoBwTjoxFl91uiG_RNYSxj2FPS6TcZjNaE3ezJqE67VfOx6fZo1b2AZ5N81n2_cPlt8Wn2dWXj8vFxdVMMUpikuC6bZRkui50U3GtW16xvMlZ3XKttFacQg15VWtQmuY100XNE97kqqU10LPs5cF36F0QU0aDyEtCK47zHCdieSC0k2sxeLORfiecNOJPwPlOSB-N6kEoiivaFFhLjgugsqEFL3UuG6015g1JXu-m28ZmA1qB3af0yPT4xJqV6NxWMF4zUrNk8Goy8O5mhBD_8eSJ6lJZhLGtS2YqVVOJi6pMTqTkPFHzv1BpaNgY5Sy0JsWPBK-PBImJ8CN2cgxBLL9e_wf7-ZgtDqzyLgQP7V1CCBb7Tr_9pNh3upg6Pcle3E_mnei2telvdvP-Dw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Gomaa, Mokhtar R</creator><creator>El Rifay, Amira S</creator><creator>Shehata, Mahmoud</creator><creator>Kandeil, Ahmed</creator><creator>Nabil Kamel, Mina</creator><creator>Marouf, Mohamed A</creator><creator>GabAllah, Mohamed</creator><creator>El Taweel, Ahmed</creator><creator>Kayed, Ahmed E</creator><creator>Kutkat, Omnia</creator><creator>Moatasim, Yassmin</creator><creator>Mahmoud, Sara H</creator><creator>Abo Shama, Noura M</creator><creator>El Sayes, Mohamed</creator><creator>Mostafa, Ahmed</creator><creator>El-Shesheny, Rabeh</creator><creator>McKenzie, Pamela P</creator><creator>Webby, Richard J</creator><creator>Kayali, Ghazi</creator><creator>Ali, Mohamed A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1011-5608</orcidid><orcidid>https://orcid.org/0000-0002-7051-1389</orcidid><orcidid>https://orcid.org/0000-0002-2878-5714</orcidid><orcidid>https://orcid.org/0000-0002-5387-1622</orcidid><orcidid>https://orcid.org/0000-0003-3253-6961</orcidid><orcidid>https://orcid.org/0000-0001-7556-9398</orcidid><orcidid>https://orcid.org/0000-0002-6181-1072</orcidid><orcidid>https://orcid.org/0000-0003-2256-2816</orcidid><orcidid>https://orcid.org/0000-0003-2159-2511</orcidid><orcidid>https://orcid.org/0000-0002-8798-2240</orcidid><orcidid>https://orcid.org/0000-0002-4397-7132</orcidid><orcidid>https://orcid.org/0000-0001-7947-3609</orcidid><orcidid>https://orcid.org/0000-0002-9585-955X</orcidid><orcidid>https://orcid.org/0000-0002-0439-3476</orcidid><orcidid>https://orcid.org/0000-0002-9130-3079</orcidid></search><sort><creationdate>20210301</creationdate><title>Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort</title><author>Gomaa, Mokhtar R ; El Rifay, Amira S ; Shehata, Mahmoud ; Kandeil, Ahmed ; Nabil Kamel, Mina ; Marouf, Mohamed A ; GabAllah, Mohamed ; El Taweel, Ahmed ; Kayed, Ahmed E ; Kutkat, Omnia ; Moatasim, Yassmin ; Mahmoud, Sara H ; Abo Shama, Noura M ; El Sayes, Mohamed ; Mostafa, Ahmed ; El-Shesheny, Rabeh ; McKenzie, Pamela P ; Webby, Richard J ; Kayali, Ghazi ; Ali, Mohamed A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c731t-ba08fbca7d84db69ddf9672b278f9dcddc93e8e268decd3287d489a7db2cf38e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antibodies, Neutralizing - blood</topic><topic>Antibodies, Viral - blood</topic><topic>Biology and Life Sciences</topic><topic>Causes of</topic><topic>Child</topic><topic>Chronic illnesses</topic><topic>Cohort Studies</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - transmission</topic><topic>COVID-19 - virology</topic><topic>Demographic aspects</topic><topic>Diabetes mellitus</topic><topic>Disease transmission</topic><topic>Egypt - epidemiology</topic><topic>Family</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Households</topic><topic>Human populations</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Infections</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>People and Places</topic><topic>Polymerase chain reaction</topic><topic>Research and Analysis Methods</topic><topic>Respiratory diseases</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>SARS-CoV-2 - genetics</topic><topic>SARS-CoV-2 - immunology</topic><topic>SARS-CoV-2 - physiology</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Viral diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomaa, Mokhtar R</creatorcontrib><creatorcontrib>El Rifay, Amira S</creatorcontrib><creatorcontrib>Shehata, Mahmoud</creatorcontrib><creatorcontrib>Kandeil, Ahmed</creatorcontrib><creatorcontrib>Nabil Kamel, Mina</creatorcontrib><creatorcontrib>Marouf, Mohamed A</creatorcontrib><creatorcontrib>GabAllah, Mohamed</creatorcontrib><creatorcontrib>El Taweel, Ahmed</creatorcontrib><creatorcontrib>Kayed, Ahmed E</creatorcontrib><creatorcontrib>Kutkat, Omnia</creatorcontrib><creatorcontrib>Moatasim, Yassmin</creatorcontrib><creatorcontrib>Mahmoud, Sara H</creatorcontrib><creatorcontrib>Abo Shama, Noura M</creatorcontrib><creatorcontrib>El Sayes, Mohamed</creatorcontrib><creatorcontrib>Mostafa, Ahmed</creatorcontrib><creatorcontrib>El-Shesheny, Rabeh</creatorcontrib><creatorcontrib>McKenzie, Pamela P</creatorcontrib><creatorcontrib>Webby, Richard J</creatorcontrib><creatorcontrib>Kayali, Ghazi</creatorcontrib><creatorcontrib>Ali, Mohamed A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomaa, Mokhtar R</au><au>El Rifay, Amira S</au><au>Shehata, Mahmoud</au><au>Kandeil, Ahmed</au><au>Nabil Kamel, Mina</au><au>Marouf, Mohamed A</au><au>GabAllah, Mohamed</au><au>El Taweel, Ahmed</au><au>Kayed, Ahmed E</au><au>Kutkat, Omnia</au><au>Moatasim, Yassmin</au><au>Mahmoud, Sara H</au><au>Abo Shama, Noura M</au><au>El Sayes, Mohamed</au><au>Mostafa, Ahmed</au><au>El-Shesheny, Rabeh</au><au>McKenzie, Pamela P</au><au>Webby, Richard J</au><au>Kayali, Ghazi</au><au>Ali, Mohamed A</au><au>Fouchier, Ron A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>17</volume><issue>3</issue><spage>e1009413</spage><pages>e1009413-</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participating in an ongoing cohort study of influenza incidence and prevalence in rural Egypt were followed. Baseline enrollment was done from August 2015 to March 2017. The study protocol was amended in April 2020 to allow COVID-19 incidence and seroprevalence studies. A total of 290 households including 1598 participants were enrolled and followed from April to October 2020 in four study sites. When a participant showed respiratory illness symptoms, a serum sample and a nasal and an oropharyngeal swab were obtained. Swabs were tested by RT-PCR for SARS-CoV-2 infection. If positive, the subject was followed and swabs collected on days three, six, nine, and 14 after the first swab day and a serum sample obtained on day 14. All subjects residing with the index case were swabbed following the same sampling schedule. Sera were collected from cohort participants in October 2020 to assess seroprevalence. Swabs were tested by RT-PCR. Sera were tested by Microneutralization Assay to measure the neutralizing antibody titer. Incidence of COVID-19, household secondary attack rate, and seroprevalence in the cohort were determined. The incidence of COVID-19 was 6.9% and the household secondary attack rate was 89.8%. Transmission within households occurred within two-days of confirming the index case. Infections were asymptomatic or mild with symptoms resolving within 10 days. The majority developed a neutralizing antibody titer by day 14 post onset. The overall seroprevalence among cohort participants was 34.8%. These results suggest that within-household transmission is high in Egypt. Asymptomatic or mild illness is common. Most infections seroconvert and have a durable neutralizing antibody titer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33705496</pmid><doi>10.1371/journal.ppat.1009413</doi><orcidid>https://orcid.org/0000-0002-1011-5608</orcidid><orcidid>https://orcid.org/0000-0002-7051-1389</orcidid><orcidid>https://orcid.org/0000-0002-2878-5714</orcidid><orcidid>https://orcid.org/0000-0002-5387-1622</orcidid><orcidid>https://orcid.org/0000-0003-3253-6961</orcidid><orcidid>https://orcid.org/0000-0001-7556-9398</orcidid><orcidid>https://orcid.org/0000-0002-6181-1072</orcidid><orcidid>https://orcid.org/0000-0003-2256-2816</orcidid><orcidid>https://orcid.org/0000-0003-2159-2511</orcidid><orcidid>https://orcid.org/0000-0002-8798-2240</orcidid><orcidid>https://orcid.org/0000-0002-4397-7132</orcidid><orcidid>https://orcid.org/0000-0001-7947-3609</orcidid><orcidid>https://orcid.org/0000-0002-9585-955X</orcidid><orcidid>https://orcid.org/0000-0002-0439-3476</orcidid><orcidid>https://orcid.org/0000-0002-9130-3079</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7374 |
| ispartof | PLoS pathogens, 2021-03, Vol.17 (3), p.e1009413 |
| issn | 1553-7374 1553-7366 1553-7374 |
| language | eng |
| recordid | cdi_plos_journals_2513690220 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Public Library of Science (PLoS); PubMed Central |
| subjects | Adolescent Adult Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Biology and Life Sciences Causes of Child Chronic illnesses Cohort Studies Coronaviridae Coronaviruses COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - transmission COVID-19 - virology Demographic aspects Diabetes mellitus Disease transmission Egypt - epidemiology Family Female Health aspects Health care Households Human populations Humans Hypertension Incidence Infections Male Medicine and Health Sciences Middle Aged Pandemics People and Places Polymerase chain reaction Research and Analysis Methods Respiratory diseases Risk analysis Risk factors SARS-CoV-2 - genetics SARS-CoV-2 - immunology SARS-CoV-2 - physiology Seroepidemiologic Studies Serology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases Young Adult |
| title | Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort |
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