Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice
Following curative immunotherapy of B16F10 tumors, ~60% of mice develop a strong antibody response against cell-surface tumor antigens. Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react with syngeneic and allogeneic tumor cell lines M...
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| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0248903-e0248903 |
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| creator | Kang, Byong H Momin, Noor Moynihan, Kelly D Silva, Murillo Li, Yingzhong Irvine, Darrell J Wittrup, K Dane |
| description | Following curative immunotherapy of B16F10 tumors, ~60% of mice develop a strong antibody response against cell-surface tumor antigens. Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react with syngeneic and allogeneic tumor cell lines MC38, EL.4, 4T1, and CT26. We identified the envelope glycoprotein (env) of a murine endogenous retrovirus (ERV) as the antigen accounting for the majority of this humoral response. A systemically administered anti-env monoclonal antibody cloned from such a response protects against tumor challenge, and prophylactic vaccination against the env protein protects a majority of naive mice from tumor establishment following subcutaneous inoculation with B16F10 cells. These results suggest the potential for effective prophylactic vaccination against analogous HERV-K env expressed in numerous human cancers. |
| doi_str_mv | 10.1371/journal.pone.0248903 |
| format | Article |
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Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react with syngeneic and allogeneic tumor cell lines MC38, EL.4, 4T1, and CT26. We identified the envelope glycoprotein (env) of a murine endogenous retrovirus (ERV) as the antigen accounting for the majority of this humoral response. A systemically administered anti-env monoclonal antibody cloned from such a response protects against tumor challenge, and prophylactic vaccination against the env protein protects a majority of naive mice from tumor establishment following subcutaneous inoculation with B16F10 cells. These results suggest the potential for effective prophylactic vaccination against analogous HERV-K env expressed in numerous human cancers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0248903</identifier><identifier>PMID: 33857179</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Animals ; Antibodies ; Antibodies, Neoplasm - immunology ; Anticancer properties ; Antigen presentation ; Antigen-antibody reactions ; Antigens ; Antitumor activity ; Beta cells ; Bioengineering ; Biology and Life Sciences ; Biotin ; Buffers ; Cancer ; Cell Line, Tumor ; Chemical engineering ; Clear cell-type renal cell carcinoma ; Cytotoxicity ; Dendritic cells ; Dilution ; Editing ; Endogenous Retroviruses - immunology ; Engineering ; Gene Products, env - immunology ; Glioblastoma ; Glycoproteins ; Head & neck cancer ; Head and neck cancer ; Immune checkpoint ; Immunoglobulin G ; Immunosurveillance ; Immunotherapy ; Immunotherapy - methods ; Infrared imaging ; Infrared imaging systems ; Kidney cancer ; Lung cancer ; Lymphocytes ; Lymphocytes T ; Materials science ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Melanoma ; Membranes ; Mice ; Mice, Inbred C57BL ; Monoclonal antibodies ; Myoglobins ; Neoplasms - immunology ; Neoplasms - therapy ; Oncology, Experimental ; Pancreas ; Patients ; Physiological aspects ; Proteins ; Research and Analysis Methods ; Room temperature ; Soybeans ; Squamous cell carcinoma ; Technology ; Toxicity ; Trypsin ; Trypsin inhibitors ; Tumor antigens ; Viral proteins</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0248903-e0248903</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Kang et al 2021 Kang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-880930b5e2da510c6d3bc36eadad9e4dbbc46c232f878d07fabfb53fd594a0263</citedby><cites>FETCH-LOGICAL-c692t-880930b5e2da510c6d3bc36eadad9e4dbbc46c232f878d07fabfb53fd594a0263</cites><orcidid>0000-0003-2398-5896 ; 0000-0001-6200-7863 ; 0000-0003-3145-6089</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33857179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Najbauer, Joseph</contributor><creatorcontrib>Kang, Byong H</creatorcontrib><creatorcontrib>Momin, Noor</creatorcontrib><creatorcontrib>Moynihan, Kelly D</creatorcontrib><creatorcontrib>Silva, Murillo</creatorcontrib><creatorcontrib>Li, Yingzhong</creatorcontrib><creatorcontrib>Irvine, Darrell J</creatorcontrib><creatorcontrib>Wittrup, K Dane</creatorcontrib><title>Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Following curative immunotherapy of B16F10 tumors, ~60% of mice develop a strong antibody response against cell-surface tumor antigens. Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react with syngeneic and allogeneic tumor cell lines MC38, EL.4, 4T1, and CT26. We identified the envelope glycoprotein (env) of a murine endogenous retrovirus (ERV) as the antigen accounting for the majority of this humoral response. A systemically administered anti-env monoclonal antibody cloned from such a response protects against tumor challenge, and prophylactic vaccination against the env protein protects a majority of naive mice from tumor establishment following subcutaneous inoculation with B16F10 cells. These results suggest the potential for effective prophylactic vaccination against analogous HERV-K env expressed in numerous human cancers.</description><subject>Adenocarcinoma</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Neoplasm - immunology</subject><subject>Anticancer properties</subject><subject>Antigen presentation</subject><subject>Antigen-antibody reactions</subject><subject>Antigens</subject><subject>Antitumor activity</subject><subject>Beta cells</subject><subject>Bioengineering</subject><subject>Biology and Life Sciences</subject><subject>Biotin</subject><subject>Buffers</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Chemical engineering</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Cytotoxicity</subject><subject>Dendritic cells</subject><subject>Dilution</subject><subject>Editing</subject><subject>Endogenous Retroviruses - immunology</subject><subject>Engineering</subject><subject>Gene Products, env - immunology</subject><subject>Glioblastoma</subject><subject>Glycoproteins</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Immune checkpoint</subject><subject>Immunoglobulin G</subject><subject>Immunosurveillance</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Infrared imaging</subject><subject>Infrared imaging systems</subject><subject>Kidney cancer</subject><subject>Lung cancer</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Materials science</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Melanoma</subject><subject>Membranes</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Monoclonal antibodies</subject><subject>Myoglobins</subject><subject>Neoplasms - 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antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice</title><author>Kang, Byong H ; Momin, Noor ; Moynihan, Kelly D ; Silva, Murillo ; Li, Yingzhong ; Irvine, Darrell J ; Wittrup, K Dane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-880930b5e2da510c6d3bc36eadad9e4dbbc46c232f878d07fabfb53fd594a0263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Neoplasm - immunology</topic><topic>Anticancer properties</topic><topic>Antigen presentation</topic><topic>Antigen-antibody reactions</topic><topic>Antigens</topic><topic>Antitumor activity</topic><topic>Beta cells</topic><topic>Bioengineering</topic><topic>Biology and Life Sciences</topic><topic>Biotin</topic><topic>Buffers</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Chemical engineering</topic><topic>Clear cell-type renal cell carcinoma</topic><topic>Cytotoxicity</topic><topic>Dendritic cells</topic><topic>Dilution</topic><topic>Editing</topic><topic>Endogenous Retroviruses - immunology</topic><topic>Engineering</topic><topic>Gene Products, env - immunology</topic><topic>Glioblastoma</topic><topic>Glycoproteins</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Immune checkpoint</topic><topic>Immunoglobulin G</topic><topic>Immunosurveillance</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Infrared imaging</topic><topic>Infrared imaging systems</topic><topic>Kidney cancer</topic><topic>Lung cancer</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Materials science</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Melanoma</topic><topic>Membranes</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Monoclonal antibodies</topic><topic>Myoglobins</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Oncology, Experimental</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Room temperature</topic><topic>Soybeans</topic><topic>Squamous cell carcinoma</topic><topic>Technology</topic><topic>Toxicity</topic><topic>Trypsin</topic><topic>Trypsin inhibitors</topic><topic>Tumor antigens</topic><topic>Viral proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Byong H</creatorcontrib><creatorcontrib>Momin, Noor</creatorcontrib><creatorcontrib>Moynihan, Kelly D</creatorcontrib><creatorcontrib>Silva, Murillo</creatorcontrib><creatorcontrib>Li, Yingzhong</creatorcontrib><creatorcontrib>Irvine, Darrell J</creatorcontrib><creatorcontrib>Wittrup, K 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Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-04-15</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0248903</spage><epage>e0248903</epage><pages>e0248903-e0248903</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Following curative immunotherapy of B16F10 tumors, ~60% of mice develop a strong antibody response against cell-surface tumor antigens. Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react with syngeneic and allogeneic tumor cell lines MC38, EL.4, 4T1, and CT26. We identified the envelope glycoprotein (env) of a murine endogenous retrovirus (ERV) as the antigen accounting for the majority of this humoral response. A systemically administered anti-env monoclonal antibody cloned from such a response protects against tumor challenge, and prophylactic vaccination against the env protein protects a majority of naive mice from tumor establishment following subcutaneous inoculation with B16F10 cells. These results suggest the potential for effective prophylactic vaccination against analogous HERV-K env expressed in numerous human cancers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33857179</pmid><doi>10.1371/journal.pone.0248903</doi><tpages>e0248903</tpages><orcidid>https://orcid.org/0000-0003-2398-5896</orcidid><orcidid>https://orcid.org/0000-0001-6200-7863</orcidid><orcidid>https://orcid.org/0000-0003-3145-6089</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2513232761 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adenocarcinoma Animals Antibodies Antibodies, Neoplasm - immunology Anticancer properties Antigen presentation Antigen-antibody reactions Antigens Antitumor activity Beta cells Bioengineering Biology and Life Sciences Biotin Buffers Cancer Cell Line, Tumor Chemical engineering Clear cell-type renal cell carcinoma Cytotoxicity Dendritic cells Dilution Editing Endogenous Retroviruses - immunology Engineering Gene Products, env - immunology Glioblastoma Glycoproteins Head & neck cancer Head and neck cancer Immune checkpoint Immunoglobulin G Immunosurveillance Immunotherapy Immunotherapy - methods Infrared imaging Infrared imaging systems Kidney cancer Lung cancer Lymphocytes Lymphocytes T Materials science Medical prognosis Medical research Medicine and Health Sciences Melanoma Membranes Mice Mice, Inbred C57BL Monoclonal antibodies Myoglobins Neoplasms - immunology Neoplasms - therapy Oncology, Experimental Pancreas Patients Physiological aspects Proteins Research and Analysis Methods Room temperature Soybeans Squamous cell carcinoma Technology Toxicity Trypsin Trypsin inhibitors Tumor antigens Viral proteins |
| title | Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T05%3A53%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunotherapy-induced%20antibodies%20to%20endogenous%20retroviral%20envelope%20glycoprotein%20confer%20tumor%20protection%20in%20mice&rft.jtitle=PloS%20one&rft.au=Kang,%20Byong%20H&rft.date=2021-04-15&rft.volume=16&rft.issue=4&rft.spage=e0248903&rft.epage=e0248903&rft.pages=e0248903-e0248903&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0248903&rft_dat=%3Cgale_plos_%3EA658586357%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2513232761&rft_id=info:pmid/33857179&rft_galeid=A658586357&rft_doaj_id=oai_doaj_org_article_71a03d82b9834e24a26869f51fafa8cd&rfr_iscdi=true |