Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis
Evidence on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticoids for rheumatoid arthritis (RA) is inconclusive and is not up to date. This systematic review assessed the effectiveness and safety of these anti-inflammatories (AI) in the treatment of RA. COCHRANE (CENTRAL), MEDLINE...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-04, Vol.16 (4), p.e0248866-e0248866, Article 0248866 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0248866 |
|---|---|
| container_issue | 4 |
| container_start_page | e0248866 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Paglia, Mariana Del Grossi Silva, Marcus Tolentino Lopes, Luciane Cruz Barberato-Filho, Silvio Mazzei, Lauren Giustti Abe, Flavia Casale Bergamaschi, Cristiane de Cassia |
| description | Evidence on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticoids for rheumatoid arthritis (RA) is inconclusive and is not up to date. This systematic review assessed the effectiveness and safety of these anti-inflammatories (AI) in the treatment of RA. COCHRANE (CENTRAL), MEDLINE, EMBASE, CINAHL, Web of Science and Virtual Health Library were searched to identify randomized controlled trials (RCT) with adults which used AI (dose represented in mg/day) compared with placebo or active controls and was carried out up to December of 2019. Reviewers, in pairs and independently, selected studies, performed the data extraction and assessed the risk of bias. The quality of the evidence was assessed by GRADE. Network meta-analyses were performed using the Stata v.14.2. Twenty-six articles were selected (NSAIDs = 21 and corticoids = 5). Naproxen 1,000 improved physical function, reduced pain and the number of painful joints compared to placebo. Etoricoxib 90 reduced the number of painful joints compared to placebo. Naproxen 750 reduced the number of swollen joints, except for etoricoxib 90. Naproxen 1,000, etoricoxib 90 and diclofenac 150 were better than placebo regarding patient assessment. Assessment physician showed that NSAIDs were better than placebo. Meta-analyses were not performed for prednisolone and prednisone. Naproxen 1,000 was the most effective drug and celecoxib 200 showed fewer adverse events. However, the low quality of the evidence observed for the outcomes with NSAIDs, the absence of meta-analyses to assess the outcomes with corticoids, as well as the risk of bias observed, indicate that future RCT can confirm such findings. |
| doi_str_mv | 10.1371/journal.pone.0248866 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2509589393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A657706445</galeid><doaj_id>oai_doaj_org_article_15e63e1de2f84772b7835a6f73faa14b</doaj_id><sourcerecordid>A657706445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-3422810d3986a0fa195c9926001149ba017abab251c93db66735d015258856a13</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggiISEQyuJD4jhcIFUrDpUqVaKUW2uSTHZdErvYTpc-BO-Mw25Xu6gXlS9iTb75x__YkyTPKZlRXtL3l3Z0BvrZlTU4IyyXUogHySGtOMsEI_zhzv4geeL9JSEFj9Dj5IBzyYSg5DD5c-ExtV3aWBd0Y3XrUzBtaqzJfEAXA9DHSNCZNl0PwwDBOo0-1SYNS0yDQwgDmjCJuCWOE6DbFFxYOh20_5Ce30SlGNZN6vBa42pdAcPKup_pgAEyiEZuvPZPk0cd9B6fbb5HycXnT9_nX7PTsy8n8-PTrBGMhYznjElKWl5JAaQDWhVNVTFBCKV5VQOhJdRQs4I2FW9rIUpetIQWrJCyEED5UfJyrXvVW682nfSKFaQqZMUrHomTNdFauFRXTg_gbpQFrf4FrFsomDrWo6IFCo60RdbJvCxZXUpegOhK3gHQvI5aHzfVxnrAtondctDvie7_MXqpFvZaSRI9cREF3mwEnP01og9q0L7BvgeDdpzOTSMpmJicvfoPvdvdhlpANBBv1sa6zSSqjkVRlkTkeRGp2R1UXC0O8a0Y7HSM7yW83UuITMDfYQGj9-rk_Nv92bMf--zrHXaJ0Ielt_0YtDV-H8zXYOOs9w67bZMpUdPU3HZDTVOjNlMT017sXtA26XZMIvBuDaywtp1vNJoGtxghRHBJaVXFHS8jLe9Pz3WAycfcjibwvzd8NAM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509589393</pqid></control><display><type>article</type><title>Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Paglia, Mariana Del Grossi ; Silva, Marcus Tolentino ; Lopes, Luciane Cruz ; Barberato-Filho, Silvio ; Mazzei, Lauren Giustti ; Abe, Flavia Casale ; Bergamaschi, Cristiane de Cassia</creator><contributor>Florez, Ivan D.</contributor><creatorcontrib>Paglia, Mariana Del Grossi ; Silva, Marcus Tolentino ; Lopes, Luciane Cruz ; Barberato-Filho, Silvio ; Mazzei, Lauren Giustti ; Abe, Flavia Casale ; Bergamaschi, Cristiane de Cassia ; Florez, Ivan D.</creatorcontrib><description>Evidence on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticoids for rheumatoid arthritis (RA) is inconclusive and is not up to date. This systematic review assessed the effectiveness and safety of these anti-inflammatories (AI) in the treatment of RA. COCHRANE (CENTRAL), MEDLINE, EMBASE, CINAHL, Web of Science and Virtual Health Library were searched to identify randomized controlled trials (RCT) with adults which used AI (dose represented in mg/day) compared with placebo or active controls and was carried out up to December of 2019. Reviewers, in pairs and independently, selected studies, performed the data extraction and assessed the risk of bias. The quality of the evidence was assessed by GRADE. Network meta-analyses were performed using the Stata v.14.2. Twenty-six articles were selected (NSAIDs = 21 and corticoids = 5). Naproxen 1,000 improved physical function, reduced pain and the number of painful joints compared to placebo. Etoricoxib 90 reduced the number of painful joints compared to placebo. Naproxen 750 reduced the number of swollen joints, except for etoricoxib 90. Naproxen 1,000, etoricoxib 90 and diclofenac 150 were better than placebo regarding patient assessment. Assessment physician showed that NSAIDs were better than placebo. Meta-analyses were not performed for prednisolone and prednisone. Naproxen 1,000 was the most effective drug and celecoxib 200 showed fewer adverse events. However, the low quality of the evidence observed for the outcomes with NSAIDs, the absence of meta-analyses to assess the outcomes with corticoids, as well as the risk of bias observed, indicate that future RCT can confirm such findings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0248866</identifier><identifier>PMID: 33826610</identifier><language>eng</language><publisher>SAN FRANCISCO: Public Library Science</publisher><subject>Acids ; Active control ; Arthritis ; Aspirin ; Autoimmune diseases ; Biology and Life Sciences ; Budesonide ; Celecoxib ; Clinical trials ; Comparators ; Corticoids ; Corticosteroids ; Dexamethasone ; Diclofenac ; Drug dosages ; Drug therapy ; Flurbiprofen ; Fluticasone ; Grip strength ; Health risks ; Health services ; Hydrocortisone ; Ibuprofen ; Indomethacin ; Inflammatory diseases ; Joint diseases ; Joints (anatomy) ; Ketoprofen ; Medicine and health sciences ; Mefenamic acid ; Meloxicam ; Meta-analysis ; Methylprednisolone ; Multidisciplinary Sciences ; Naproxen ; Nonsteroidal anti-inflammatory drugs ; Pain ; Patients ; Pharmaceutical sciences ; Physical Sciences ; Physicians ; Piroxicam ; Placebos ; Prednisolone ; Quality of life ; Research and Analysis Methods ; Rheumatoid arthritis ; Safety ; Science & Technology ; Science & Technology - Other Topics ; Standard deviation ; Stiffness ; Systematic review ; Testing</subject><ispartof>PloS one, 2021-04, Vol.16 (4), p.e0248866-e0248866, Article 0248866</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Paglia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Paglia et al 2021 Paglia et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>24</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000638119900037</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c622t-3422810d3986a0fa195c9926001149ba017abab251c93db66735d015258856a13</citedby><cites>FETCH-LOGICAL-c622t-3422810d3986a0fa195c9926001149ba017abab251c93db66735d015258856a13</cites><orcidid>0000-0002-3684-3275 ; 0000-0001-5179-3125 ; 0000-0002-7186-9075 ; 0000-0001-8611-5594 ; 0000-0002-0889-4673 ; 0000-0003-4268-4298</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026036/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026036/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,2930,23873,27931,27932,39265,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33826610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Florez, Ivan D.</contributor><creatorcontrib>Paglia, Mariana Del Grossi</creatorcontrib><creatorcontrib>Silva, Marcus Tolentino</creatorcontrib><creatorcontrib>Lopes, Luciane Cruz</creatorcontrib><creatorcontrib>Barberato-Filho, Silvio</creatorcontrib><creatorcontrib>Mazzei, Lauren Giustti</creatorcontrib><creatorcontrib>Abe, Flavia Casale</creatorcontrib><creatorcontrib>Bergamaschi, Cristiane de Cassia</creatorcontrib><title>Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis</title><title>PloS one</title><addtitle>PLOS ONE</addtitle><addtitle>PLoS One</addtitle><description>Evidence on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticoids for rheumatoid arthritis (RA) is inconclusive and is not up to date. This systematic review assessed the effectiveness and safety of these anti-inflammatories (AI) in the treatment of RA. COCHRANE (CENTRAL), MEDLINE, EMBASE, CINAHL, Web of Science and Virtual Health Library were searched to identify randomized controlled trials (RCT) with adults which used AI (dose represented in mg/day) compared with placebo or active controls and was carried out up to December of 2019. Reviewers, in pairs and independently, selected studies, performed the data extraction and assessed the risk of bias. The quality of the evidence was assessed by GRADE. Network meta-analyses were performed using the Stata v.14.2. Twenty-six articles were selected (NSAIDs = 21 and corticoids = 5). Naproxen 1,000 improved physical function, reduced pain and the number of painful joints compared to placebo. Etoricoxib 90 reduced the number of painful joints compared to placebo. Naproxen 750 reduced the number of swollen joints, except for etoricoxib 90. Naproxen 1,000, etoricoxib 90 and diclofenac 150 were better than placebo regarding patient assessment. Assessment physician showed that NSAIDs were better than placebo. Meta-analyses were not performed for prednisolone and prednisone. Naproxen 1,000 was the most effective drug and celecoxib 200 showed fewer adverse events. However, the low quality of the evidence observed for the outcomes with NSAIDs, the absence of meta-analyses to assess the outcomes with corticoids, as well as the risk of bias observed, indicate that future RCT can confirm such findings.</description><subject>Acids</subject><subject>Active control</subject><subject>Arthritis</subject><subject>Aspirin</subject><subject>Autoimmune diseases</subject><subject>Biology and Life Sciences</subject><subject>Budesonide</subject><subject>Celecoxib</subject><subject>Clinical trials</subject><subject>Comparators</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dexamethasone</subject><subject>Diclofenac</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Flurbiprofen</subject><subject>Fluticasone</subject><subject>Grip strength</subject><subject>Health risks</subject><subject>Health services</subject><subject>Hydrocortisone</subject><subject>Ibuprofen</subject><subject>Indomethacin</subject><subject>Inflammatory diseases</subject><subject>Joint diseases</subject><subject>Joints (anatomy)</subject><subject>Ketoprofen</subject><subject>Medicine and health sciences</subject><subject>Mefenamic acid</subject><subject>Meloxicam</subject><subject>Meta-analysis</subject><subject>Methylprednisolone</subject><subject>Multidisciplinary Sciences</subject><subject>Naproxen</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pain</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Physical Sciences</subject><subject>Physicians</subject><subject>Piroxicam</subject><subject>Placebos</subject><subject>Prednisolone</subject><subject>Quality of life</subject><subject>Research and Analysis Methods</subject><subject>Rheumatoid arthritis</subject><subject>Safety</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Standard deviation</subject><subject>Stiffness</subject><subject>Systematic review</subject><subject>Testing</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggiISEQyuJD4jhcIFUrDpUqVaKUW2uSTHZdErvYTpc-BO-Mw25Xu6gXlS9iTb75x__YkyTPKZlRXtL3l3Z0BvrZlTU4IyyXUogHySGtOMsEI_zhzv4geeL9JSEFj9Dj5IBzyYSg5DD5c-ExtV3aWBd0Y3XrUzBtaqzJfEAXA9DHSNCZNl0PwwDBOo0-1SYNS0yDQwgDmjCJuCWOE6DbFFxYOh20_5Ce30SlGNZN6vBa42pdAcPKup_pgAEyiEZuvPZPk0cd9B6fbb5HycXnT9_nX7PTsy8n8-PTrBGMhYznjElKWl5JAaQDWhVNVTFBCKV5VQOhJdRQs4I2FW9rIUpetIQWrJCyEED5UfJyrXvVW682nfSKFaQqZMUrHomTNdFauFRXTg_gbpQFrf4FrFsomDrWo6IFCo60RdbJvCxZXUpegOhK3gHQvI5aHzfVxnrAtondctDvie7_MXqpFvZaSRI9cREF3mwEnP01og9q0L7BvgeDdpzOTSMpmJicvfoPvdvdhlpANBBv1sa6zSSqjkVRlkTkeRGp2R1UXC0O8a0Y7HSM7yW83UuITMDfYQGj9-rk_Nv92bMf--zrHXaJ0Ielt_0YtDV-H8zXYOOs9w67bZMpUdPU3HZDTVOjNlMT017sXtA26XZMIvBuDaywtp1vNJoGtxghRHBJaVXFHS8jLe9Pz3WAycfcjibwvzd8NAM</recordid><startdate>20210407</startdate><enddate>20210407</enddate><creator>Paglia, Mariana Del Grossi</creator><creator>Silva, Marcus Tolentino</creator><creator>Lopes, Luciane Cruz</creator><creator>Barberato-Filho, Silvio</creator><creator>Mazzei, Lauren Giustti</creator><creator>Abe, Flavia Casale</creator><creator>Bergamaschi, Cristiane de Cassia</creator><general>Public Library Science</general><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3684-3275</orcidid><orcidid>https://orcid.org/0000-0001-5179-3125</orcidid><orcidid>https://orcid.org/0000-0002-7186-9075</orcidid><orcidid>https://orcid.org/0000-0001-8611-5594</orcidid><orcidid>https://orcid.org/0000-0002-0889-4673</orcidid><orcidid>https://orcid.org/0000-0003-4268-4298</orcidid></search><sort><creationdate>20210407</creationdate><title>Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis</title><author>Paglia, Mariana Del Grossi ; Silva, Marcus Tolentino ; Lopes, Luciane Cruz ; Barberato-Filho, Silvio ; Mazzei, Lauren Giustti ; Abe, Flavia Casale ; Bergamaschi, Cristiane de Cassia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-3422810d3986a0fa195c9926001149ba017abab251c93db66735d015258856a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acids</topic><topic>Active control</topic><topic>Arthritis</topic><topic>Aspirin</topic><topic>Autoimmune diseases</topic><topic>Biology and Life Sciences</topic><topic>Budesonide</topic><topic>Celecoxib</topic><topic>Clinical trials</topic><topic>Comparators</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dexamethasone</topic><topic>Diclofenac</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Flurbiprofen</topic><topic>Fluticasone</topic><topic>Grip strength</topic><topic>Health risks</topic><topic>Health services</topic><topic>Hydrocortisone</topic><topic>Ibuprofen</topic><topic>Indomethacin</topic><topic>Inflammatory diseases</topic><topic>Joint diseases</topic><topic>Joints (anatomy)</topic><topic>Ketoprofen</topic><topic>Medicine and health sciences</topic><topic>Mefenamic acid</topic><topic>Meloxicam</topic><topic>Meta-analysis</topic><topic>Methylprednisolone</topic><topic>Multidisciplinary Sciences</topic><topic>Naproxen</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pain</topic><topic>Patients</topic><topic>Pharmaceutical sciences</topic><topic>Physical Sciences</topic><topic>Physicians</topic><topic>Piroxicam</topic><topic>Placebos</topic><topic>Prednisolone</topic><topic>Quality of life</topic><topic>Research and Analysis Methods</topic><topic>Rheumatoid arthritis</topic><topic>Safety</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Standard deviation</topic><topic>Stiffness</topic><topic>Systematic review</topic><topic>Testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paglia, Mariana Del Grossi</creatorcontrib><creatorcontrib>Silva, Marcus Tolentino</creatorcontrib><creatorcontrib>Lopes, Luciane Cruz</creatorcontrib><creatorcontrib>Barberato-Filho, Silvio</creatorcontrib><creatorcontrib>Mazzei, Lauren Giustti</creatorcontrib><creatorcontrib>Abe, Flavia Casale</creatorcontrib><creatorcontrib>Bergamaschi, Cristiane de Cassia</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paglia, Mariana Del Grossi</au><au>Silva, Marcus Tolentino</au><au>Lopes, Luciane Cruz</au><au>Barberato-Filho, Silvio</au><au>Mazzei, Lauren Giustti</au><au>Abe, Flavia Casale</au><au>Bergamaschi, Cristiane de Cassia</au><au>Florez, Ivan D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis</atitle><jtitle>PloS one</jtitle><stitle>PLOS ONE</stitle><addtitle>PLoS One</addtitle><date>2021-04-07</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e0248866</spage><epage>e0248866</epage><pages>e0248866-e0248866</pages><artnum>0248866</artnum><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evidence on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticoids for rheumatoid arthritis (RA) is inconclusive and is not up to date. This systematic review assessed the effectiveness and safety of these anti-inflammatories (AI) in the treatment of RA. COCHRANE (CENTRAL), MEDLINE, EMBASE, CINAHL, Web of Science and Virtual Health Library were searched to identify randomized controlled trials (RCT) with adults which used AI (dose represented in mg/day) compared with placebo or active controls and was carried out up to December of 2019. Reviewers, in pairs and independently, selected studies, performed the data extraction and assessed the risk of bias. The quality of the evidence was assessed by GRADE. Network meta-analyses were performed using the Stata v.14.2. Twenty-six articles were selected (NSAIDs = 21 and corticoids = 5). Naproxen 1,000 improved physical function, reduced pain and the number of painful joints compared to placebo. Etoricoxib 90 reduced the number of painful joints compared to placebo. Naproxen 750 reduced the number of swollen joints, except for etoricoxib 90. Naproxen 1,000, etoricoxib 90 and diclofenac 150 were better than placebo regarding patient assessment. Assessment physician showed that NSAIDs were better than placebo. Meta-analyses were not performed for prednisolone and prednisone. Naproxen 1,000 was the most effective drug and celecoxib 200 showed fewer adverse events. However, the low quality of the evidence observed for the outcomes with NSAIDs, the absence of meta-analyses to assess the outcomes with corticoids, as well as the risk of bias observed, indicate that future RCT can confirm such findings.</abstract><cop>SAN FRANCISCO</cop><pub>Public Library Science</pub><pmid>33826610</pmid><doi>10.1371/journal.pone.0248866</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0002-3684-3275</orcidid><orcidid>https://orcid.org/0000-0001-5179-3125</orcidid><orcidid>https://orcid.org/0000-0002-7186-9075</orcidid><orcidid>https://orcid.org/0000-0001-8611-5594</orcidid><orcidid>https://orcid.org/0000-0002-0889-4673</orcidid><orcidid>https://orcid.org/0000-0003-4268-4298</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-04, Vol.16 (4), p.e0248866-e0248866, Article 0248866 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2509589393 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Active control Arthritis Aspirin Autoimmune diseases Biology and Life Sciences Budesonide Celecoxib Clinical trials Comparators Corticoids Corticosteroids Dexamethasone Diclofenac Drug dosages Drug therapy Flurbiprofen Fluticasone Grip strength Health risks Health services Hydrocortisone Ibuprofen Indomethacin Inflammatory diseases Joint diseases Joints (anatomy) Ketoprofen Medicine and health sciences Mefenamic acid Meloxicam Meta-analysis Methylprednisolone Multidisciplinary Sciences Naproxen Nonsteroidal anti-inflammatory drugs Pain Patients Pharmaceutical sciences Physical Sciences Physicians Piroxicam Placebos Prednisolone Quality of life Research and Analysis Methods Rheumatoid arthritis Safety Science & Technology Science & Technology - Other Topics Standard deviation Stiffness Systematic review Testing |
| title | Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T23%3A23%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20corticoids%20and%20non-steroidal%20anti-inflammatories%20in%20the%20treatment%20of%20rheumatoid%20arthritis:%20Systematic%20review%20and%20network%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Paglia,%20Mariana%20Del%20Grossi&rft.date=2021-04-07&rft.volume=16&rft.issue=4&rft.spage=e0248866&rft.epage=e0248866&rft.pages=e0248866-e0248866&rft.artnum=0248866&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0248866&rft_dat=%3Cgale_plos_%3EA657706445%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2509589393&rft_id=info:pmid/33826610&rft_galeid=A657706445&rft_doaj_id=oai_doaj_org_article_15e63e1de2f84772b7835a6f73faa14b&rfr_iscdi=true |