Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation co...

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Veröffentlicht in:	PloS one 2021-04, Vol.16 (4), p.e0249591
Hauptverfasser:	Wei, George Z, Saraswat Ohri, Sujata, Khattar, Nicolas K, Listerman, Adam W, Doyle, Catherine H, Andres, Kariena R, Karuppagounder, Saravanan S, Ratan, Rajiv R, Whittemore, Scott R, Hetman, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Apoptosis Biology and Life Sciences Brain Complications Complications and side effects Cytotoxicity Drug therapy Editing Electronic mail Enzyme inhibitors Females Funding Gene expression Guidelines Health aspects Hemorrhage Homeostasis Hydroxylase Hypoxia Hypoxia-inducible factors Ischemia Laboratory animals Males Medical research Medicine Medicine and Health Sciences Nervous system Neurobiology Neurosciences Oxidative stress Oxidoreductases Pharmacology Prolyl hydroxylase Protein synthesis Proteins Public health Recovery (Medical) Research and Analysis Methods Research facilities Reviews Rodents Sex Spinal cord injuries Stroke Surgery Toxicology
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