alms1 mutant zebrafish do not show hair cell phenotypes seen in other cilia mutants

Multiple cilia-associated genes have been shown to affect hair cells in zebrafish (Danio rerio), including the human deafness gene dcdc2, the radial spoke gene rsph9, and multiple intraflagellar transport (IFT) and transition zone genes. Recently a zebrafish alms1 mutant was generated. The ALMS1 gen...

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Veröffentlicht in:	PloS one 2021-04, Vol.16 (4), p.e0246844-e0246844
Hauptverfasser:	Parkinson, Lauren, Stawicki, Tamara M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Antibodies Apoptosis Biology and Life Sciences Cell culture Cell death Cell surface Cilia Danio rerio Defects Experiments Gene mutations Genes Genetic aspects Hair Hair cells Hair cells (Mechanoreceptors) Health aspects Hearing loss Hearing protection Labeling Lateral line Mammals Mechanotransduction Medicine and Health Sciences Mutants Mutation Neurosciences Obesity Outer hair cells Phenotypes Physiological aspects Polarity Protein transport Proteins Research and Analysis Methods Siblings Startle response Vestibular diseases Zebra fish Zebrafish
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