Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

N-hydroxylating flavin-dependent monooxygenases (FMOs) are involved in the biosynthesis of hydroxamate siderophores, playing a key role in microbial virulence. Herein, we report the first structural and kinetic characterization of a novel alkyl diamine N-hydroxylase DesB from Streptomyces sviceus (S...

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Veröffentlicht in:	PloS one 2021-03, Vol.16 (3), p.e0248385
Hauptverfasser:	Giddings, Lesley-Ann, Lountos, George T, Kim, Kang Woo, Brockley, Matthew, Needle, Danielle, Cherry, Scott, Tropea, Joseph E, Waugh, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial agents Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES Biocatalysis Biochemistry Biology Biology and Life Sciences Biosynthesis Cadaverine Cadaverine - metabolism Cadavers Cancer Catalytic Domain Chelating agents Chemical properties Chemical research Chromatography Data analysis Deferoxamine Deferoxamine - metabolism Dinitrocresols - metabolism Editing Enzymes Flavin-Adenine Dinucleotide - metabolism Flavins - metabolism Functional groups Genes Genomics Holoenzymes - metabolism Homology Hydroxylase Hydroxylases Hydroxylation Identification and classification Ionization Iron Kinetics Liquid chromatography Mass spectrometry Mass spectroscopy Medical research Metal oxide semiconductors Microorganisms Mixed Function Oxygenases - biosynthesis Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - metabolism NADP - metabolism Ornithine - metabolism Oxidation-Reduction Pathogens Physical Sciences Physiological aspects Proteins Quadrupoles Research and Analysis Methods Siderophores Siderophores (Microbiology) Siderophores - biosynthesis Streptomyces Streptomyces - enzymology Structure Therapeutic targets Virulence
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