Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification

Children with Down syndrome (DS) are susceptible to two blood disorders, transient abnormal myelopoiesis (TAM) and Down syndrome-associated acute megakaryocytic leukemia (DS-AMKL). Mutations in GATA binding protein 1 (GATA1) have been identified as the cause of these diseases, and the expression lev...

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Veröffentlicht in:	PloS one 2021-03, Vol.16 (3), p.e0247595-e0247595
Hauptverfasser:	Matsuo, Shiori, Nishinaka-Arai, Yoko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Nakahata, Tatsutoshi, Niwa, Akira, Saito, Megumu K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences CD34 antigen Cell culture Chromosomes Cloning Data analysis Developmental stages Differentiation Down syndrome Down's syndrome Drafting software Editing Electronic mail Engineering research Fetuses Funding GATA-1 protein Gene expression Genetic aspects Genomes Graduate schools Graduate studies Hematopoiesis Hemopoiesis Ligands Mail Medicine Methodology Mutation Myelocytes Physiological aspects Pluripotency Proteins R&D Research & development Research and Analysis Methods Research facilities Stem cells Vascular endothelial growth factor Visualization
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